Between June 30, 1991 and August 1, 2019, Randy Johnson fanned the most hitters, with 4,424 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,424 | 537 | 273 | 136 | .667 | 523 | 3.19 | 91 | 35 | 2 | 3638.0 | 2,933 | 1,288 | 1,447 | 361 | 1,191 | 177 | 6 | 33 | 14,888 | 91 | 10.94 | 2.95 | 3.71 | 0.89 | 29.7 | 8.0 | 1.13 | .294 | 3.58 | 7.26 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | R. Clemens | 3,142 | 488 | 229 | 128 | .641 | 487 | 3.27 | 49 | 20 | 0 | 3285.0 | 2,815 | 1,192 | 1,312 | 258 | 1,129 | 119 | 0 | 41 | 13,612 | 104 | 8.61 | 3.09 | 2.78 | 0.71 | 23.1 | 8.3 | 1.20 | .285 | 3.59 | 7.71 |
| 4 |  | CC Sabathia | 3,068 | 555 | 251 | 159 | .612 | 555 | 3.73 | 38 | 12 | 0 | 3560.1 | 3,386 | 1,474 | 1,612 | 379 | 1,090 | 122 | 0 | 44 | 14,909 | 74 | 7.76 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .293 | 4.07 | 8.56 |
| 5 |  | C. Schilling | 3,038 | 497 | 212 | 135 | .611 | 431 | 3.42 | 83 | 20 | 14 | 3158.1 | 2,887 | 1,200 | 1,261 | 340 | 663 | 51 | 47 | 37 | 12,826 | 66 | 8.66 | 1.89 | 4.58 | 0.97 | 23.7 | 5.2 | 1.12 | .292 | 3.59 | 8.23 |
| 6 |  | J. Verlander | 2,902 | 442 | 218 | 127 | .632 | 442 | 3.35 | 24 | 8 | 0 | 2910.2 | 2,490 | 1,085 | 1,172 | 300 | 839 | 96 | 0 | 27 | 11,927 | 86 | 8.97 | 2.59 | 3.46 | 0.93 | 24.3 | 7.0 | 1.14 | .281 | 3.62 | 7.70 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | G. Maddux | 2,742 | 588 | 289 | 168 | .632 | 588 | 3.03 | 82 | 28 | 0 | 3986.1 | 3,713 | 1,340 | 1,496 | 285 | 647 | 109 | 0 | 116 | 16,058 | 49 | 6.19 | 1.46 | 4.24 | 0.64 | 17.1 | 4.0 | 1.09 | .279 | 3.38 | 8.38 |
| 9 |  | J. Smoltz | 2,646 | 632 | 183 | 117 | .610 | 390 | 3.22 | 41 | 14 | 154 | 2870.1 | 2,534 | 1,027 | 1,111 | 233 | 777 | 50 | 204 | 74 | 11,737 | 110 | 8.30 | 2.44 | 3.41 | 0.73 | 22.5 | 6.6 | 1.15 | .287 | 3.48 | 7.95 |
| 10 |  | M. Scherzer | 2,638 | 358 | 168 | 87 | .659 | 349 | 3.17 | 10 | 5 | 0 | 2252.0 | 1,847 | 793 | 856 | 246 | 610 | 85 | 2 | 19 | 9,120 | 65 | 10.54 | 2.44 | 4.32 | 0.98 | 28.9 | 6.7 | 1.09 | .289 | 3.42 | 7.38 |
| 11 |  | Z. Greinke | 2,570 | 478 | 197 | 122 | .618 | 437 | 3.36 | 16 | 5 | 1 | 2809.1 | 2,603 | 1,049 | 1,126 | 286 | 658 | 68 | 8 | 25 | 11,481 | 85 | 8.23 | 2.11 | 3.91 | 0.92 | 22.4 | 5.7 | 1.16 | .293 | 3.61 | 8.34 |
| 12 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 13 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 14 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 15 | | C. Hamels | 2,512 | 412 | 162 | 117 | .581 | 411 | 3.38 | 17 | 7 | 0 | 2652.2 | 2,365 | 997 | 1,072 | 302 | 745 | 96 | 0 | 42 | 10,896 | 57 | 8.52 | 2.53 | 3.37 | 1.02 | 23.1 | 6.8 | 1.17 | .285 | 3.64 | 8.02 |
| 16 |  | F. Hernandez | 2,501 | 412 | 169 | 132 | .561 | 411 | 3.38 | 25 | 11 | 0 | 2696.2 | 2,452 | 1,014 | 1,130 | 256 | 788 | 103 | 0 | 16 | 11,133 | 154 | 8.35 | 2.63 | 3.17 | 0.85 | 22.5 | 7.1 | 1.20 | .293 | 3.77 | 8.18 |
| 17 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 18 |  | C. Kershaw | 2,397 | 337 | 163 | 71 | .697 | 335 | 2.42 | 25 | 15 | 0 | 2219.1 | 1,673 | 596 | 651 | 160 | 563 | 32 | 1 | 27 | 8,741 | 85 | 9.72 | 2.28 | 4.26 | 0.65 | 27.4 | 6.4 | 1.01 | .271 | 2.64 | 6.78 |
| 19 |  | J. Lester | 2,306 | 402 | 186 | 105 | .639 | 401 | 3.52 | 15 | 4 | 0 | 2485.0 | 2,316 | 971 | 1,057 | 250 | 794 | 83 | 0 | 8 | 10,346 | 61 | 8.35 | 2.88 | 2.90 | 0.91 | 22.3 | 7.7 | 1.25 | .299 | 3.83 | 8.39 |
| 20 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 21 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 22 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 23 | | T. Glavine | 2,186 | 561 | 261 | 158 | .623 | 561 | 3.45 | 43 | 20 | 0 | 3649.1 | 3,545 | 1,399 | 1,525 | 293 | 1,266 | 51 | 0 | 120 | 15,367 | 46 | 5.39 | 3.12 | 1.73 | 0.72 | 14.2 | 8.2 | 1.32 | .281 | 3.76 | 8.74 |
| 24 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 25 | | K. Brown | 2,154 | 412 | 179 | 119 | .601 | 402 | 3.20 | 58 | 15 | 0 | 2767.2 | 2,602 | 983 | 1,127 | 180 | 720 | 124 | 1 | 35 | 11,462 | 86 | 7.00 | 2.34 | 2.99 | 0.59 | 18.8 | 6.3 | 1.20 | .292 | 3.66 | 8.46 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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