Between May 19, 1976 and September 27, 1998, Nolan Ryan struck out the most hitters, with 3,877 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 3,877 | 543 | 216 | 190 | .532 | 543 | 3.24 | 123 | 37 | 0 | 3670.1 | 2,738 | 1,322 | 1,509 | 222 | 1,752 | 101 | 0 | 55 | 15,313 | 199 | 9.51 | 4.30 | 2.21 | 0.54 | 25.3 | 11.4 | 1.22 | .269 | 3.70 | 6.71 |
| 2 |  | R. Clemens | 3,153 | 450 | 233 | 124 | .653 | 449 | 2.95 | 114 | 44 | 0 | 3274.2 | 2,732 | 1,072 | 1,188 | 214 | 1,012 | 105 | 0 | 44 | 13,389 | 82 | 8.67 | 2.78 | 3.12 | 0.59 | 23.5 | 7.6 | 1.14 | .283 | 3.27 | 7.51 |
| 3 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 4 |  | M. Langston | 2,421 | 432 | 178 | 156 | .533 | 423 | 3.94 | 81 | 18 | 0 | 2901.0 | 2,654 | 1,270 | 1,398 | 302 | 1,260 | 46 | 1 | 28 | 12,288 | 87 | 7.51 | 3.91 | 1.92 | 0.94 | 19.7 | 10.3 | 1.35 | .285 | 4.34 | 8.23 |
| 5 |  | R. Johnson | 2,329 | 296 | 143 | 79 | .644 | 287 | 3.36 | 56 | 23 | 2 | 1978.1 | 1,523 | 739 | 827 | 169 | 943 | 92 | 4 | 12 | 8,302 | 71 | 10.60 | 4.29 | 2.47 | 0.77 | 28.1 | 11.4 | 1.25 | .284 | 3.76 | 6.93 |
| 6 | | B. Blyleven | 2,322 | 468 | 189 | 163 | .537 | 464 | 3.58 | 143 | 36 | 0 | 3294.1 | 3,145 | 1,309 | 1,437 | 313 | 897 | 114 | 1 | 47 | 13,682 | 83 | 6.34 | 2.45 | 2.59 | 0.86 | 17.0 | 6.6 | 1.23 | .282 | 3.93 | 8.59 |
| 7 | | D. Cone | 2,243 | 359 | 168 | 93 | .644 | 330 | 3.17 | 55 | 21 | 1 | 2396.2 | 1,980 | 845 | 927 | 191 | 895 | 76 | 9 | 32 | 9,925 | 122 | 8.42 | 3.36 | 2.51 | 0.72 | 22.6 | 9.0 | 1.20 | .274 | 3.48 | 7.44 |
| 8 | | F. Tanana | 2,239 | 552 | 204 | 203 | .501 | 535 | 3.79 | 108 | 24 | 1 | 3568.1 | 3,517 | 1,501 | 1,685 | 389 | 1,076 | 110 | 7 | 106 | 15,097 | 104 | 5.65 | 2.71 | 2.08 | 0.98 | 14.8 | 7.1 | 1.29 | .277 | 4.25 | 8.87 |
| 9 | | D. Eckersley | 2,224 | 1,031 | 182 | 162 | .529 | 331 | 3.56 | 93 | 17 | 388 | 3072.0 | 2,913 | 1,214 | 1,309 | 329 | 634 | 67 | 572 | 82 | 12,630 | 22 | 6.52 | 1.86 | 3.51 | 0.96 | 17.6 | 5.0 | 1.15 | .276 | 3.83 | 8.53 |
| 10 |  | S. Carlton | 2,186 | 387 | 178 | 124 | .589 | 373 | 3.30 | 106 | 24 | 1 | 2722.1 | 2,446 | 997 | 1,146 | 229 | 927 | 25 | 6 | 77 | 11,285 | 98 | 7.23 | 3.06 | 2.36 | 0.76 | 19.4 | 8.2 | 1.24 | .280 | 3.79 | 8.09 |
| 11 | | C. Hough | 2,164 | 707 | 197 | 203 | .493 | 440 | 3.78 | 107 | 13 | 48 | 3526.1 | 3,081 | 1,480 | 1,689 | 355 | 1,522 | 154 | 166 | 40 | 15,000 | 169 | 5.52 | 3.88 | 1.42 | 0.91 | 14.4 | 10.1 | 1.31 | .252 | 4.31 | 7.86 |
| 12 | | D. Gooden | 2,150 | 377 | 185 | 103 | .642 | 374 | 3.33 | 68 | 24 | 1 | 2580.2 | 2,318 | 956 | 1,044 | 169 | 843 | 66 | 1 | 36 | 10,706 | 67 | 7.50 | 2.94 | 2.55 | 0.59 | 20.1 | 7.9 | 1.22 | .287 | 3.64 | 8.08 |
| 13 | | D. Martinez | 2,149 | 692 | 245 | 193 | .559 | 562 | 3.70 | 122 | 30 | 8 | 3999.2 | 3,897 | 1,643 | 1,835 | 372 | 1,165 | 122 | 51 | 70 | 16,754 | 84 | 4.84 | 2.62 | 1.84 | 0.84 | 12.8 | 7.0 | 1.27 | .272 | 4.13 | 8.77 |
| 14 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 15 |  | G. Maddux | 2,024 | 403 | 202 | 117 | .633 | 399 | 2.75 | 89 | 28 | 0 | 2849.1 | 2,503 | 872 | 1,001 | 141 | 654 | 76 | 3 | 110 | 11,517 | 45 | 6.39 | 2.07 | 3.09 | 0.45 | 17.6 | 5.7 | 1.11 | .274 | 3.16 | 7.91 |
| 16 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 17 | | C. Finley | 1,951 | 403 | 153 | 129 | .543 | 346 | 3.66 | 56 | 14 | 0 | 2461.2 | 2,347 | 1,002 | 1,117 | 231 | 1,024 | 63 | 24 | 25 | 10,485 | 102 | 7.13 | 3.74 | 1.91 | 0.84 | 18.6 | 9.8 | 1.37 | .293 | 4.08 | 8.58 |
| 18 |  | J. Smoltz | 1,942 | 327 | 146 | 105 | .582 | 327 | 3.36 | 46 | 13 | 0 | 2228.0 | 1,924 | 832 | 916 | 181 | 734 | 34 | 0 | 53 | 9,201 | 117 | 7.84 | 2.96 | 2.65 | 0.73 | 21.1 | 8.0 | 1.19 | .276 | 3.70 | 7.77 |
| 19 | | D. Darwin | 1,942 | 716 | 171 | 182 | .484 | 371 | 3.84 | 53 | 9 | 32 | 3016.2 | 2,951 | 1,286 | 1,432 | 321 | 874 | 81 | 171 | 101 | 12,716 | 52 | 5.79 | 2.61 | 2.22 | 0.96 | 15.3 | 6.9 | 1.27 | .277 | 4.27 | 8.80 |
| 20 | | O. Hershiser | 1,912 | 468 | 190 | 133 | .588 | 428 | 3.33 | 68 | 25 | 5 | 2926.2 | 2,722 | 1,084 | 1,239 | 216 | 916 | 95 | 18 | 105 | 12,238 | 113 | 5.88 | 2.82 | 2.09 | 0.66 | 15.6 | 7.5 | 1.24 | .275 | 3.81 | 8.37 |
| 21 | | F. Viola | 1,844 | 421 | 176 | 150 | .540 | 420 | 3.73 | 74 | 16 | 0 | 2836.1 | 2,827 | 1,175 | 1,303 | 294 | 864 | 48 | 0 | 39 | 11,933 | 86 | 5.85 | 2.74 | 2.13 | 0.93 | 15.5 | 7.2 | 1.30 | .285 | 4.13 | 8.97 |
| 22 | | B. Witt | 1,795 | 377 | 131 | 140 | .483 | 356 | 4.73 | 44 | 9 | 0 | 2226.0 | 2,216 | 1,171 | 1,283 | 219 | 1,248 | 33 | 11 | 34 | 9,918 | 115 | 7.26 | 5.05 | 1.44 | 0.89 | 18.1 | 12.6 | 1.56 | .302 | 5.19 | 8.96 |
| 23 | | P. Niekro | 1,782 | 417 | 170 | 149 | .533 | 407 | 3.69 | 113 | 19 | 2 | 2852.1 | 2,753 | 1,169 | 1,334 | 264 | 1,131 | 61 | 7 | 43 | 12,178 | 106 | 5.62 | 3.57 | 1.58 | 0.83 | 14.6 | 9.3 | 1.36 | .278 | 4.21 | 8.69 |
| 24 | | R. Guidry | 1,763 | 358 | 170 | 90 | .654 | 322 | 3.29 | 95 | 26 | 4 | 2376.1 | 2,183 | 868 | 947 | 226 | 624 | 12 | 17 | 24 | 9,725 | 55 | 6.68 | 2.36 | 2.83 | 0.86 | 18.1 | 6.4 | 1.18 | .276 | 3.59 | 8.27 |
| 25 | | S. Fernandez | 1,743 | 307 | 114 | 96 | .543 | 300 | 3.36 | 25 | 9 | 1 | 1866.2 | 1,421 | 696 | 749 | 191 | 715 | 41 | 2 | 33 | 7,668 | 22 | 8.40 | 3.45 | 2.44 | 0.92 | 22.7 | 9.3 | 1.14 | .247 | 3.61 | 6.85 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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