Between October 8, 1915 and September 28, 1940, Lefty Grove struck out the most batters, with 2,215 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Grove | 2,215 | 595 | 293 | 134 | .686 | 436 | 3.02 | 288 | 35 | 54 | 3804.0 | 3,693 | 1,276 | 1,512 | 154 | 1,142 | 39 | 123 | 16,022 | 48 | 5.24 | 2.70 | 1.94 | 0.36 | 13.8 | 7.1 | 1.27 | .284 | 3.58 | 8.74 | |
| 2 | | D. Vance | 2,027 | 433 | 197 | 136 | .592 | 345 | 3.23 | 216 | 29 | 12 | 2937.0 | 2,782 | 1,054 | 1,230 | 131 | 821 | 74 | 48 | 12,243 | 36 | 6.21 | 2.52 | 2.47 | 0.40 | 16.6 | 6.7 | 1.23 | .288 | 3.77 | 8.53 | |
| 3 | | R. Ruffing | 1,796 | 549 | 229 | 203 | .530 | 463 | 3.87 | 293 | 36 | 18 | 3760.2 | 3,743 | 1,617 | 1,874 | 220 | 1,388 | 52 | 69 | 16,126 | 42 | 4.30 | 3.32 | 1.29 | 0.53 | 11.1 | 8.6 | 1.36 | .278 | 4.48 | 8.96 | |
| 4 |  | W. Johnson | 1,628 | 431 | 211 | 151 | .583 | 357 | 2.66 | 265 | 50 | 21 | 3137.0 | 2,782 | 1,153 | 71 | 824 | 102 | 70 | 12,821 | 54 | 4.67 | 2.36 | 1.98 | 0.20 | 12.7 | 6.4 | 1.15 | .266 | 3.31 | 7.98 | ||
| 5 | | B. Grimes | 1,521 | 616 | 270 | 212 | .560 | 496 | 3.54 | 314 | 35 | 17 | 4177.0 | 4,420 | 2,048 | 149 | 1,297 | 97 | 94 | 17,974 | 92 | 3.28 | 2.79 | 1.17 | 0.32 | 8.5 | 7.2 | 1.37 | .286 | 4.41 | 9.52 | ||
| 6 | | C. Hubbell | 1,511 | 473 | 227 | 133 | .631 | 380 | 2.86 | 235 | 35 | 32 | 3201.1 | 3,050 | 1,018 | 1,200 | 193 | 617 | 50 | 77 | 13,146 | 43 | 4.25 | 1.73 | 2.45 | 0.54 | 11.5 | 4.7 | 1.15 | .265 | 3.37 | 8.57 | |
| 7 | | C. Root | 1,416 | 613 | 193 | 153 | .558 | 326 | 3.52 | 171 | 21 | 42 | 3092.0 | 3,121 | 1,211 | 1,400 | 181 | 852 | 80 | 182 | 13,048 | 21 | 4.12 | 2.48 | 1.66 | 0.53 | 10.9 | 6.5 | 1.28 | .279 | 4.08 | 9.08 | |
| 8 | | E. Whitehill | 1,353 | 541 | 218 | 185 | .541 | 473 | 4.36 | 226 | 16 | 11 | 3564.0 | 3,915 | 1,728 | 2,018 | 192 | 1,431 | 102 | 46 | 15,773 | 43 | 3.42 | 3.61 | 0.95 | 0.48 | 8.6 | 9.1 | 1.50 | .293 | 5.10 | 9.89 | |
| 9 | | L. Gomez | 1,351 | 331 | 168 | 92 | .646 | 283 | 3.28 | 163 | 26 | 10 | 2261.0 | 2,067 | 823 | 968 | 125 | 922 | 18 | 31 | 9,623 | 33 | 5.38 | 3.67 | 1.47 | 0.50 | 14.0 | 9.6 | 1.32 | .269 | 3.85 | 8.23 | |
| 10 | | T. Bridges | 1,347 | 338 | 162 | 111 | .593 | 294 | 3.73 | 168 | 27 | 8 | 2280.0 | 2,185 | 944 | 1,111 | 147 | 991 | 29 | 33 | 9,874 | 46 | 5.32 | 3.91 | 1.36 | 0.58 | 13.6 | 10.0 | 1.39 | .277 | 4.39 | 8.63 | |
| 11 | | B. Hadley | 1,281 | 500 | 156 | 159 | .495 | 344 | 4.21 | 133 | 14 | 22 | 2829.2 | 2,828 | 1,323 | 1,531 | 153 | 1,390 | 61 | 95 | 12,472 | 64 | 4.07 | 4.42 | 0.92 | 0.49 | 10.3 | 11.1 | 1.49 | .279 | 4.87 | 8.99 | |
| 12 | | R. Faber | 1,206 | 579 | 220 | 190 | .537 | 432 | 3.22 | 241 | 25 | 21 | 3607.1 | 3,691 | 1,621 | 106 | 1,055 | 82 | 103 | 15,283 | 40 | 3.01 | 2.63 | 1.14 | 0.26 | 7.9 | 6.9 | 1.32 | .279 | 4.04 | 9.21 | ||
| 13 | | W. Hoyt | 1,203 | 674 | 237 | 182 | .566 | 425 | 3.59 | 226 | 26 | 53 | 3760.1 | 4,044 | 1,502 | 1,775 | 154 | 1,007 | 49 | 173 | 16,069 | 39 | 2.88 | 2.41 | 1.19 | 0.37 | 7.5 | 6.3 | 1.34 | .285 | 4.25 | 9.68 | |
| 14 | | S. Sam Jones | 1,178 | 598 | 225 | 208 | .520 | 479 | 3.85 | 248 | 36 | 27 | 3731.0 | 3,963 | 1,928 | 154 | 1,342 | 70 | 90 | 16,136 | 70 | 2.84 | 3.24 | 0.88 | 0.37 | 7.3 | 8.3 | 1.42 | .284 | 4.65 | 9.56 | ||
| 15 | | G. Alexander | 1,170 | 460 | 246 | 145 | .629 | 412 | 2.68 | 290 | 53 | 20 | 3471.1 | 3,424 | 1,260 | 129 | 502 | 31 | 36 | 14,034 | 23 | 3.03 | 1.30 | 2.33 | 0.33 | 8.3 | 3.6 | 1.13 | .270 | 3.27 | 8.88 | ||
| 16 | | D. Dean | 1,161 | 314 | 150 | 82 | .647 | 227 | 3.01 | 154 | 26 | 31 | 1958.2 | 1,905 | 655 | 766 | 93 | 448 | 27 | 77 | 8,129 | 12 | 5.33 | 2.06 | 2.59 | 0.43 | 14.3 | 5.5 | 1.20 | .283 | 3.52 | 8.75 | |
| 17 | | B. Shawkey | 1,139 | 399 | 164 | 124 | .569 | 265 | 3.13 | 159 | 25 | 27 | 2404.1 | 2,226 | 835 | 978 | 100 | 823 | 36 | 99 | 9,984 | 35 | 4.26 | 3.08 | 1.38 | 0.37 | 11.4 | 8.2 | 1.27 | .270 | 3.66 | 8.33 | |
| 18 | | G. Uhle | 1,138 | 513 | 200 | 166 | .546 | 368 | 4.01 | 232 | 21 | 27 | 3114.0 | 3,417 | 1,635 | 119 | 968 | 116 | 115 | 13,606 | 55 | 3.29 | 2.80 | 1.18 | 0.34 | 8.4 | 7.1 | 1.41 | .293 | 4.73 | 9.88 | ||
| 19 | | P. Derringer | 1,133 | 412 | 168 | 149 | .530 | 322 | 3.46 | 189 | 26 | 18 | 2638.1 | 2,864 | 1,013 | 1,194 | 110 | 530 | 26 | 68 | 11,155 | 41 | 3.86 | 1.81 | 2.14 | 0.38 | 10.2 | 4.8 | 1.29 | .294 | 4.07 | 9.77 | |
| 20 | | B. Newsom | 1,133 | 293 | 121 | 102 | .543 | 249 | 4.21 | 149 | 15 | 13 | 1963.0 | 1,957 | 918 | 1,053 | 125 | 986 | 25 | 30 | 8,638 | 34 | 5.19 | 4.52 | 1.15 | 0.57 | 13.1 | 11.4 | 1.50 | .288 | 4.83 | 8.97 | |
| 21 | | D. Luque | 1,124 | 546 | 194 | 178 | .522 | 364 | 3.24 | 205 | 26 | 29 | 3207.0 | 3,225 | 1,404 | 112 | 912 | 27 | 127 | 13,416 | 48 | 3.15 | 2.56 | 1.23 | 0.31 | 8.4 | 6.8 | 1.29 | .277 | 3.94 | 9.05 | ||
| 22 | | R. Walberg | 1,089 | 544 | 155 | 141 | .524 | 306 | 4.17 | 139 | 15 | 34 | 2642.0 | 2,793 | 1,224 | 1,425 | 164 | 1,029 | 27 | 146 | 11,532 | 40 | 3.71 | 3.51 | 1.06 | 0.56 | 9.4 | 8.9 | 1.45 | .285 | 4.85 | 9.51 | |
| 23 | | E. Rixey | 1,088 | 581 | 234 | 213 | .523 | 478 | 3.18 | 258 | 31 | 11 | 3895.2 | 4,053 | 1,723 | 85 | 864 | 64 | 81 | 16,256 | 71 | 2.51 | 2.00 | 1.26 | 0.20 | 6.7 | 5.3 | 1.26 | .280 | 3.98 | 9.36 | ||
| 24 | | L. French | 1,055 | 500 | 177 | 153 | .536 | 350 | 3.47 | 185 | 35 | 17 | 2849.0 | 3,068 | 1,100 | 1,308 | 151 | 739 | 34 | 93 | 12,174 | 32 | 3.33 | 2.33 | 1.43 | 0.48 | 8.7 | 6.1 | 1.34 | .286 | 4.13 | 9.69 | |
| 25 | | H. Pennock | 1,054 | 542 | 223 | 149 | .599 | 391 | 3.55 | 236 | 31 | 31 | 3278.0 | 3,618 | 1,538 | 120 | 765 | 29 | 106 | 13,902 | 52 | 2.89 | 2.10 | 1.38 | 0.33 | 7.6 | 5.5 | 1.34 | .293 | 4.22 | 9.93 | ||
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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