Between September 1, 1989 and October 3, 2012, Randy Johnson struck out the most hitters, with 4,749 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,749 | 590 | 294 | 157 | .652 | 576 | 3.25 | 97 | 37 | 2 | 3976.2 | 3,203 | 1,437 | 1,615 | 398 | 1,403 | 188 | 6 | 35 | 16,364 | 100 | 10.75 | 3.18 | 3.38 | 0.90 | 29.0 | 8.6 | 1.16 | .291 | 3.66 | 7.25 |
| 2 |  | R. Clemens | 3,501 | 540 | 262 | 141 | .650 | 539 | 3.14 | 61 | 25 | 0 | 3678.0 | 3,139 | 1,282 | 1,427 | 271 | 1,222 | 129 | 0 | 47 | 15,185 | 114 | 8.57 | 2.99 | 2.86 | 0.66 | 23.1 | 8.0 | 1.19 | .285 | 3.49 | 7.68 |
| 3 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 4 |  | C. Schilling | 3,112 | 565 | 216 | 143 | .602 | 432 | 3.43 | 83 | 20 | 22 | 3246.1 | 2,976 | 1,237 | 1,299 | 344 | 701 | 51 | 81 | 42 | 13,208 | 70 | 8.63 | 1.94 | 4.44 | 0.95 | 23.6 | 5.3 | 1.13 | .292 | 3.60 | 8.25 |
| 5 |  | G. Maddux | 3,000 | 645 | 314 | 191 | .622 | 645 | 3.07 | 92 | 30 | 0 | 4374.2 | 4,095 | 1,490 | 1,683 | 310 | 756 | 118 | 0 | 134 | 17,694 | 56 | 6.17 | 1.56 | 3.97 | 0.64 | 17.0 | 4.3 | 1.11 | .280 | 3.46 | 8.42 |
| 6 |  | J. Smoltz | 2,888 | 683 | 199 | 137 | .592 | 441 | 3.31 | 48 | 16 | 154 | 3207.0 | 2,842 | 1,178 | 1,276 | 265 | 908 | 53 | 204 | 79 | 13,152 | 135 | 8.10 | 2.55 | 3.18 | 0.74 | 22.0 | 6.9 | 1.17 | .285 | 3.58 | 7.98 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 9 | | T. Glavine | 2,421 | 613 | 284 | 174 | .620 | 613 | 3.45 | 49 | 21 | 0 | 4001.2 | 3,886 | 1,536 | 1,677 | 320 | 1,370 | 53 | 0 | 131 | 16,838 | 60 | 5.44 | 3.08 | 1.77 | 0.72 | 14.4 | 8.1 | 1.31 | .281 | 3.77 | 8.74 |
| 10 | | A. Pettitte | 2,320 | 501 | 245 | 142 | .633 | 491 | 3.86 | 25 | 4 | 0 | 3130.2 | 3,250 | 1,341 | 1,487 | 271 | 983 | 51 | 3 | 41 | 13,290 | 63 | 6.67 | 2.83 | 2.36 | 0.78 | 17.5 | 7.4 | 1.35 | .308 | 4.27 | 9.34 |
| 11 | | K. Brown | 2,286 | 455 | 198 | 135 | .595 | 445 | 3.28 | 64 | 17 | 0 | 3044.2 | 2,883 | 1,108 | 1,266 | 196 | 827 | 136 | 1 | 40 | 12,652 | 100 | 6.76 | 2.44 | 2.76 | 0.58 | 18.1 | 6.5 | 1.22 | .292 | 3.74 | 8.52 |
| 12 | | C. Finley | 2,257 | 408 | 172 | 142 | .548 | 408 | 3.89 | 52 | 14 | 0 | 2689.1 | 2,584 | 1,162 | 1,295 | 269 | 1,122 | 65 | 0 | 25 | 11,477 | 117 | 7.55 | 3.75 | 2.01 | 0.90 | 19.7 | 9.8 | 1.38 | .298 | 4.33 | 8.65 |
| 13 | | D. Cone | 2,216 | 355 | 157 | 111 | .586 | 351 | 3.55 | 41 | 17 | 0 | 2364.1 | 2,061 | 933 | 1,019 | 218 | 937 | 93 | 1 | 28 | 9,975 | 123 | 8.44 | 3.57 | 2.36 | 0.83 | 22.2 | 9.4 | 1.27 | .283 | 3.88 | 7.85 |
| 14 |  | CC Sabathia | 2,214 | 383 | 191 | 102 | .652 | 383 | 3.50 | 35 | 12 | 0 | 2564.1 | 2,361 | 998 | 1,095 | 227 | 769 | 81 | 0 | 34 | 10,622 | 50 | 7.77 | 2.70 | 2.88 | 0.80 | 20.8 | 7.2 | 1.22 | .291 | 3.84 | 8.29 |
| 15 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 16 | | J. Moyer | 2,091 | 601 | 238 | 170 | .583 | 549 | 4.23 | 28 | 8 | 0 | 3530.1 | 3,649 | 1,659 | 1,784 | 459 | 935 | 132 | 13 | 52 | 14,973 | 38 | 5.33 | 2.38 | 2.24 | 1.17 | 14.0 | 6.2 | 1.30 | .281 | 4.55 | 9.30 |
| 17 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 18 | | R. Halladay | 2,066 | 403 | 199 | 100 | .666 | 377 | 3.31 | 66 | 20 | 1 | 2687.1 | 2,591 | 987 | 1,087 | 224 | 556 | 71 | 6 | 27 | 11,005 | 52 | 6.92 | 1.86 | 3.72 | 0.75 | 18.8 | 5.1 | 1.17 | .293 | 3.64 | 8.68 |
| 19 | | D. Wells | 2,042 | 557 | 226 | 145 | .609 | 487 | 4.16 | 54 | 12 | 6 | 3270.1 | 3,476 | 1,510 | 1,628 | 390 | 652 | 81 | 29 | 50 | 13,698 | 88 | 5.62 | 1.79 | 3.13 | 1.07 | 14.9 | 4.8 | 1.26 | .293 | 4.48 | 9.57 |
| 20 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 21 | | K. Appier | 1,984 | 408 | 168 | 133 | .558 | 397 | 3.69 | 34 | 12 | 0 | 2573.2 | 2,391 | 1,056 | 1,146 | 229 | 921 | 79 | 2 | 50 | 10,852 | 106 | 6.94 | 3.22 | 2.15 | 0.80 | 18.3 | 8.5 | 1.29 | .283 | 4.01 | 8.36 |
| 22 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 23 | | A. Benes | 1,974 | 399 | 153 | 137 | .528 | 383 | 3.96 | 21 | 9 | 1 | 2479.1 | 2,357 | 1,090 | 1,189 | 284 | 894 | 54 | 6 | 52 | 10,531 | 63 | 7.17 | 3.25 | 2.21 | 1.03 | 18.7 | 8.5 | 1.31 | .283 | 4.32 | 8.56 |
| 24 | | A.J. Burnett | 1,971 | 345 | 137 | 121 | .531 | 340 | 4.05 | 22 | 10 | 0 | 2162.2 | 1,975 | 973 | 1,063 | 221 | 888 | 107 | 1 | 28 | 9,230 | 134 | 8.20 | 3.70 | 2.22 | 0.92 | 21.4 | 9.6 | 1.32 | .290 | 4.42 | 8.22 |
| 25 | | R. Dempster | 1,918 | 547 | 124 | 124 | .500 | 322 | 4.33 | 11 | 3 | 87 | 2215.2 | 2,177 | 1,067 | 1,153 | 241 | 992 | 85 | 185 | 46 | 9,658 | 71 | 7.79 | 4.03 | 1.93 | 0.98 | 19.9 | 10.3 | 1.43 | .301 | 4.68 | 8.84 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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