Between September 1, 1993 and October 4, 2015, Randy Johnson fanned the most batters, with 3,816 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,816 | 459 | 240 | 110 | .686 | 446 | 3.10 | 77 | 30 | 1 | 3114.0 | 2,540 | 1,072 | 1,205 | 321 | 894 | 138 | 5 | 31 | 12,644 | 63 | 11.03 | 2.58 | 4.27 | 0.93 | 30.2 | 7.1 | 1.10 | .297 | 3.48 | 7.34 |
| 2 |  | P. Martinez | 3,050 | 420 | 210 | 96 | .686 | 408 | 2.94 | 46 | 17 | 1 | 2733.1 | 2,155 | 892 | 978 | 234 | 711 | 139 | 8 | 26 | 11,003 | 62 | 10.04 | 2.34 | 4.29 | 0.77 | 27.7 | 6.5 | 1.05 | .280 | 3.22 | 7.10 |
| 3 |  | C. Schilling | 2,710 | 399 | 187 | 118 | .613 | 377 | 3.46 | 67 | 14 | 9 | 2696.2 | 2,493 | 1,038 | 1,080 | 309 | 533 | 46 | 21 | 26 | 10,941 | 55 | 9.04 | 1.78 | 5.08 | 1.03 | 24.8 | 4.9 | 1.12 | .297 | 3.60 | 8.32 |
| 4 |  | R. Clemens | 2,656 | 411 | 192 | 101 | .655 | 410 | 3.31 | 27 | 11 | 0 | 2719.1 | 2,331 | 1,001 | 1,098 | 220 | 975 | 98 | 0 | 25 | 11,318 | 93 | 8.79 | 3.23 | 2.72 | 0.73 | 23.5 | 8.6 | 1.22 | .286 | 3.63 | 7.71 |
| 5 |  | CC Sabathia | 2,574 | 452 | 214 | 129 | .624 | 452 | 3.69 | 38 | 12 | 0 | 2988.2 | 2,831 | 1,225 | 1,340 | 293 | 894 | 95 | 0 | 42 | 12,465 | 64 | 7.75 | 2.69 | 2.88 | 0.88 | 20.6 | 7.2 | 1.25 | .295 | 4.04 | 8.53 |
| 6 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 7 | | M. Mussina | 2,525 | 471 | 235 | 138 | .630 | 470 | 3.77 | 44 | 17 | 0 | 3084.0 | 3,029 | 1,292 | 1,387 | 335 | 678 | 54 | 0 | 26 | 12,672 | 57 | 7.37 | 1.98 | 3.72 | 0.98 | 19.9 | 5.4 | 1.20 | .297 | 4.05 | 8.84 |
| 8 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 9 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 10 |  | G. Maddux | 2,276 | 502 | 244 | 143 | .630 | 502 | 3.11 | 60 | 21 | 0 | 3344.2 | 3,182 | 1,157 | 1,290 | 258 | 503 | 87 | 0 | 101 | 13,501 | 37 | 6.12 | 1.35 | 4.52 | 0.69 | 16.9 | 3.7 | 1.10 | .282 | 3.47 | 8.56 |
| 11 |  | B. Colon | 2,237 | 475 | 218 | 154 | .586 | 467 | 3.97 | 36 | 13 | 0 | 2980.2 | 3,029 | 1,314 | 1,429 | 355 | 856 | 57 | 1 | 44 | 12,588 | 42 | 6.75 | 2.58 | 2.61 | 1.07 | 17.8 | 6.8 | 1.30 | .294 | 4.31 | 9.15 |
| 12 |  | J. Smoltz | 2,181 | 549 | 143 | 92 | .609 | 307 | 3.24 | 25 | 10 | 154 | 2297.0 | 2,059 | 827 | 891 | 191 | 577 | 38 | 204 | 60 | 9,368 | 78 | 8.55 | 2.26 | 3.78 | 0.75 | 23.3 | 6.2 | 1.15 | .293 | 3.49 | 8.07 |
| 13 |  | F. Hernandez | 2,142 | 334 | 143 | 101 | .586 | 334 | 3.11 | 25 | 11 | 0 | 2262.1 | 2,019 | 783 | 870 | 184 | 630 | 71 | 0 | 16 | 9,251 | 126 | 8.52 | 2.51 | 3.40 | 0.73 | 23.2 | 6.8 | 1.17 | .295 | 3.46 | 8.03 |
| 14 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 15 | | J. Peavy | 2,105 | 357 | 147 | 117 | .557 | 356 | 3.53 | 15 | 6 | 0 | 2258.1 | 2,000 | 887 | 935 | 241 | 672 | 76 | 0 | 41 | 9,318 | 42 | 8.39 | 2.68 | 3.13 | 0.96 | 22.6 | 7.2 | 1.18 | .283 | 3.73 | 7.97 |
| 16 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 17 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 18 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 19 | | T. Wakefield | 2,062 | 595 | 188 | 171 | .524 | 435 | 4.42 | 28 | 5 | 22 | 3039.1 | 2,964 | 1,493 | 1,697 | 403 | 1,109 | 179 | 77 | 30 | 13,117 | 129 | 6.11 | 3.28 | 1.86 | 1.19 | 15.7 | 8.5 | 1.34 | .273 | 5.03 | 8.78 |
| 20 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
| 21 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 22 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 23 | | J. Lackey | 1,965 | 388 | 165 | 127 | .565 | 387 | 3.92 | 18 | 8 | 0 | 2481.1 | 2,551 | 1,080 | 1,180 | 260 | 709 | 112 | 0 | 28 | 10,551 | 110 | 7.13 | 2.57 | 2.77 | 0.94 | 18.6 | 6.7 | 1.31 | .305 | 4.28 | 9.25 |
| 24 |  | J. Verlander | 1,943 | 318 | 157 | 97 | .618 | 318 | 3.52 | 21 | 7 | 0 | 2111.1 | 1,901 | 825 | 900 | 187 | 642 | 72 | 0 | 22 | 8,761 | 67 | 8.28 | 2.74 | 3.03 | 0.80 | 22.2 | 7.3 | 1.20 | .290 | 3.84 | 8.10 |
| 25 | | J. Moyer | 1,939 | 535 | 225 | 149 | .602 | 507 | 4.21 | 24 | 7 | 0 | 3256.2 | 3,348 | 1,523 | 1,631 | 436 | 842 | 123 | 6 | 47 | 13,796 | 35 | 5.36 | 2.33 | 2.30 | 1.20 | 14.1 | 6.1 | 1.29 | .279 | 4.51 | 9.25 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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