Between September 26, 1990 and June 20, 2013, Randy Johnson struck out the most batters, with 4,539 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,539 | 554 | 280 | 143 | .662 | 540 | 3.22 | 93 | 35 | 2 | 3742.1 | 3,018 | 1,338 | 1,501 | 370 | 1,282 | 183 | 6 | 33 | 15,364 | 95 | 10.92 | 3.08 | 3.54 | 0.89 | 29.5 | 8.3 | 1.15 | .295 | 3.61 | 7.26 |
| 2 |  | R. Clemens | 3,253 | 504 | 239 | 133 | .642 | 503 | 3.22 | 53 | 21 | 0 | 3409.2 | 2,908 | 1,221 | 1,350 | 261 | 1,157 | 120 | 0 | 44 | 14,100 | 104 | 8.59 | 3.05 | 2.81 | 0.69 | 23.1 | 8.2 | 1.19 | .284 | 3.56 | 7.68 |
| 3 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 4 |  | C. Schilling | 3,076 | 527 | 215 | 140 | .606 | 431 | 3.44 | 83 | 20 | 19 | 3193.1 | 2,930 | 1,219 | 1,281 | 341 | 679 | 51 | 66 | 42 | 12,986 | 69 | 8.67 | 1.91 | 4.53 | 0.96 | 23.7 | 5.2 | 1.13 | .293 | 3.61 | 8.26 |
| 5 |  | G. Maddux | 2,843 | 606 | 296 | 175 | .628 | 606 | 3.04 | 83 | 28 | 0 | 4110.1 | 3,820 | 1,387 | 1,554 | 297 | 683 | 113 | 0 | 125 | 16,573 | 53 | 6.23 | 1.50 | 4.16 | 0.65 | 17.2 | 4.1 | 1.10 | .279 | 3.40 | 8.36 |
| 6 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 7 |  | J. Smoltz | 2,714 | 650 | 186 | 127 | .594 | 408 | 3.28 | 42 | 14 | 154 | 2980.2 | 2,643 | 1,085 | 1,170 | 245 | 823 | 52 | 204 | 75 | 12,209 | 123 | 8.19 | 2.49 | 3.30 | 0.74 | 22.2 | 6.7 | 1.16 | .286 | 3.53 | 7.98 |
| 8 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 9 | | A. Pettitte | 2,378 | 513 | 250 | 147 | .630 | 503 | 3.86 | 25 | 4 | 0 | 3205.2 | 3,329 | 1,376 | 1,524 | 278 | 1,003 | 54 | 3 | 42 | 13,608 | 68 | 6.68 | 2.82 | 2.37 | 0.78 | 17.5 | 7.4 | 1.35 | .308 | 4.28 | 9.35 |
| 10 |  | CC Sabathia | 2,303 | 398 | 198 | 107 | .649 | 398 | 3.52 | 36 | 12 | 0 | 2667.1 | 2,467 | 1,043 | 1,143 | 241 | 790 | 83 | 0 | 35 | 11,050 | 52 | 7.77 | 2.67 | 2.92 | 0.81 | 20.8 | 7.1 | 1.22 | .292 | 3.86 | 8.32 |
| 11 | | T. Glavine | 2,285 | 578 | 272 | 163 | .625 | 578 | 3.41 | 48 | 21 | 0 | 3773.1 | 3,644 | 1,430 | 1,560 | 301 | 1,287 | 52 | 0 | 121 | 15,853 | 52 | 5.45 | 3.07 | 1.78 | 0.72 | 14.4 | 8.1 | 1.31 | .280 | 3.72 | 8.69 |
| 12 | | K. Brown | 2,189 | 427 | 185 | 124 | .599 | 417 | 3.24 | 58 | 15 | 0 | 2857.0 | 2,698 | 1,029 | 1,175 | 183 | 763 | 131 | 1 | 37 | 11,858 | 91 | 6.90 | 2.40 | 2.87 | 0.58 | 18.5 | 6.4 | 1.21 | .293 | 3.70 | 8.50 |
| 13 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 14 | | R. Halladay | 2,101 | 410 | 201 | 104 | .659 | 384 | 3.37 | 67 | 20 | 1 | 2721.2 | 2,624 | 1,020 | 1,120 | 233 | 573 | 75 | 6 | 27 | 11,160 | 54 | 6.95 | 1.89 | 3.67 | 0.77 | 18.8 | 5.1 | 1.17 | .292 | 3.70 | 8.68 |
| 15 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 16 | | C. Finley | 2,075 | 373 | 152 | 133 | .533 | 373 | 4.03 | 45 | 12 | 0 | 2438.1 | 2,361 | 1,092 | 1,212 | 250 | 1,026 | 62 | 0 | 22 | 10,448 | 107 | 7.66 | 3.79 | 2.02 | 0.92 | 19.9 | 9.8 | 1.39 | .300 | 4.47 | 8.71 |
| 17 | | A.J. Burnett | 2,070 | 359 | 141 | 127 | .526 | 354 | 4.01 | 22 | 10 | 0 | 2252.0 | 2,041 | 1,004 | 1,095 | 229 | 923 | 111 | 1 | 29 | 9,596 | 140 | 8.27 | 3.69 | 2.24 | 0.92 | 21.6 | 9.6 | 1.32 | .289 | 4.38 | 8.16 |
| 18 | | J. Moyer | 2,030 | 564 | 235 | 160 | .595 | 534 | 4.21 | 26 | 8 | 0 | 3407.2 | 3,507 | 1,594 | 1,707 | 448 | 890 | 128 | 7 | 48 | 14,436 | 38 | 5.36 | 2.35 | 2.28 | 1.18 | 14.1 | 6.2 | 1.29 | .280 | 4.51 | 9.26 |
| 19 | | R. Dempster | 2,008 | 562 | 128 | 132 | .492 | 337 | 4.33 | 11 | 3 | 87 | 2305.0 | 2,256 | 1,109 | 1,199 | 257 | 1,034 | 87 | 185 | 47 | 10,043 | 76 | 7.84 | 4.04 | 1.94 | 1.00 | 20.0 | 10.3 | 1.43 | .300 | 4.68 | 8.81 |
| 20 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 21 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 22 | | D. Cone | 1,962 | 320 | 143 | 99 | .591 | 317 | 3.56 | 35 | 14 | 0 | 2131.0 | 1,855 | 842 | 920 | 194 | 869 | 91 | 0 | 26 | 9,015 | 113 | 8.29 | 3.67 | 2.26 | 0.82 | 21.8 | 9.6 | 1.28 | .282 | 3.89 | 7.83 |
| 23 | | D. Wells | 1,932 | 506 | 214 | 141 | .603 | 464 | 4.23 | 54 | 12 | 3 | 3083.0 | 3,317 | 1,449 | 1,562 | 378 | 605 | 79 | 17 | 46 | 12,947 | 80 | 5.64 | 1.77 | 3.19 | 1.10 | 14.9 | 4.7 | 1.27 | .295 | 4.56 | 9.68 |
| 24 | | H. Nomo | 1,918 | 323 | 123 | 109 | .530 | 318 | 4.24 | 16 | 9 | 0 | 1976.1 | 1,768 | 932 | 993 | 251 | 908 | 38 | 2 | 31 | 8,462 | 110 | 8.73 | 4.13 | 2.11 | 1.14 | 22.7 | 10.7 | 1.35 | .284 | 4.52 | 8.05 |
| 25 |  | B. Colon | 1,885 | 395 | 180 | 124 | .592 | 389 | 4.00 | 34 | 11 | 0 | 2483.2 | 2,490 | 1,105 | 1,207 | 301 | 783 | 48 | 0 | 36 | 10,513 | 39 | 6.83 | 2.84 | 2.41 | 1.09 | 17.9 | 7.4 | 1.32 | .292 | 4.37 | 9.02 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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