Between September 26, 1992 and October 4, 2015, Randy Johnson struck out the most batters, with 4,083 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,083 | 490 | 255 | 118 | .684 | 476 | 3.13 | 84 | 32 | 2 | 3332.1 | 2,707 | 1,158 | 1,296 | 341 | 987 | 153 | 6 | 32 | 13,552 | 70 | 11.03 | 2.67 | 4.14 | 0.92 | 30.1 | 7.3 | 1.11 | .296 | 3.50 | 7.31 |
| 2 |  | P. Martinez | 3,153 | 475 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2825.1 | 2,219 | 919 | 1,006 | 239 | 759 | 141 | 22 | 30 | 11,385 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | C. Schilling | 2,863 | 429 | 199 | 125 | .614 | 407 | 3.50 | 75 | 16 | 9 | 2906.2 | 2,692 | 1,130 | 1,181 | 328 | 584 | 50 | 21 | 31 | 11,807 | 61 | 8.86 | 1.81 | 4.90 | 1.02 | 24.2 | 4.9 | 1.13 | .296 | 3.66 | 8.34 |
| 4 |  | R. Clemens | 2,799 | 436 | 202 | 112 | .643 | 435 | 3.36 | 29 | 12 | 0 | 2885.2 | 2,482 | 1,076 | 1,177 | 235 | 1,028 | 106 | 0 | 27 | 12,011 | 95 | 8.73 | 3.21 | 2.72 | 0.73 | 23.3 | 8.6 | 1.22 | .286 | 3.67 | 7.74 |
| 5 | | M. Mussina | 2,640 | 495 | 249 | 143 | .635 | 494 | 3.78 | 47 | 19 | 0 | 3251.0 | 3,189 | 1,367 | 1,463 | 354 | 718 | 57 | 0 | 28 | 13,355 | 62 | 7.31 | 1.99 | 3.68 | 0.98 | 19.8 | 5.4 | 1.20 | .296 | 4.05 | 8.83 |
| 6 |  | CC Sabathia | 2,574 | 452 | 214 | 129 | .624 | 452 | 3.69 | 38 | 12 | 0 | 2988.2 | 2,831 | 1,225 | 1,340 | 293 | 894 | 95 | 0 | 42 | 12,465 | 64 | 7.75 | 2.69 | 2.88 | 0.88 | 20.6 | 7.2 | 1.25 | .295 | 4.04 | 8.53 |
| 7 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 8 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 9 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 10 |  | G. Maddux | 2,443 | 533 | 261 | 152 | .632 | 533 | 3.07 | 68 | 23 | 0 | 3575.1 | 3,381 | 1,220 | 1,366 | 271 | 546 | 94 | 0 | 108 | 14,422 | 42 | 6.15 | 1.37 | 4.47 | 0.68 | 16.9 | 3.8 | 1.10 | .281 | 3.44 | 8.51 |
| 11 |  | J. Smoltz | 2,356 | 579 | 156 | 101 | .607 | 337 | 3.25 | 28 | 11 | 154 | 2504.1 | 2,228 | 904 | 973 | 210 | 659 | 44 | 204 | 69 | 10,234 | 84 | 8.47 | 2.37 | 3.58 | 0.75 | 23.0 | 6.4 | 1.15 | .290 | 3.50 | 8.01 |
| 12 |  | B. Colon | 2,237 | 475 | 218 | 154 | .586 | 467 | 3.97 | 36 | 13 | 0 | 2980.2 | 3,029 | 1,314 | 1,429 | 355 | 856 | 57 | 1 | 44 | 12,588 | 42 | 6.75 | 2.58 | 2.61 | 1.07 | 17.8 | 6.8 | 1.30 | .294 | 4.31 | 9.15 |
| 13 |  | F. Hernandez | 2,142 | 334 | 143 | 101 | .586 | 334 | 3.11 | 25 | 11 | 0 | 2262.1 | 2,019 | 783 | 870 | 184 | 630 | 71 | 0 | 16 | 9,251 | 126 | 8.52 | 2.51 | 3.40 | 0.73 | 23.2 | 6.8 | 1.17 | .295 | 3.46 | 8.03 |
| 14 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 15 | | T. Wakefield | 2,110 | 616 | 194 | 179 | .520 | 452 | 4.47 | 29 | 5 | 22 | 3146.1 | 3,081 | 1,562 | 1,768 | 416 | 1,172 | 185 | 78 | 32 | 13,608 | 131 | 6.04 | 3.35 | 1.80 | 1.19 | 15.5 | 8.6 | 1.35 | .274 | 5.06 | 8.81 |
| 16 | | J. Peavy | 2,105 | 357 | 147 | 117 | .557 | 356 | 3.53 | 15 | 6 | 0 | 2258.1 | 2,000 | 887 | 935 | 241 | 672 | 76 | 0 | 41 | 9,318 | 42 | 8.39 | 2.68 | 3.13 | 0.96 | 22.6 | 7.2 | 1.18 | .283 | 3.73 | 7.97 |
| 17 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 18 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 19 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 20 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
| 21 | | J. Moyer | 2,006 | 555 | 235 | 155 | .603 | 527 | 4.19 | 26 | 8 | 0 | 3374.0 | 3,465 | 1,571 | 1,682 | 443 | 873 | 127 | 6 | 48 | 14,281 | 35 | 5.35 | 2.33 | 2.30 | 1.18 | 14.0 | 6.1 | 1.29 | .279 | 4.49 | 9.24 |
| 22 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 23 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 24 | | T. Glavine | 1,971 | 512 | 232 | 144 | .617 | 512 | 3.50 | 32 | 15 | 0 | 3307.2 | 3,246 | 1,288 | 1,393 | 278 | 1,148 | 48 | 0 | 108 | 13,960 | 38 | 5.36 | 3.12 | 1.72 | 0.76 | 14.1 | 8.2 | 1.33 | .282 | 3.79 | 8.83 |
| 25 | | J. Lackey | 1,965 | 388 | 165 | 127 | .565 | 387 | 3.92 | 18 | 8 | 0 | 2481.1 | 2,551 | 1,080 | 1,180 | 260 | 709 | 112 | 0 | 28 | 10,551 | 110 | 7.13 | 2.57 | 2.77 | 0.94 | 18.6 | 6.7 | 1.31 | .305 | 4.28 | 9.25 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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