Between April 10, 1971 and April 30, 2018, Nolan Ryan struck out the most hitters, with 5,358 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,358 | 732 | 305 | 268 | .532 | 725 | 3.18 | 212 | 59 | 1 | 5028.0 | 3,679 | 1,775 | 2,026 | 295 | 2,567 | 149 | 4 | 68 | 21,054 | 260 | 9.59 | 4.59 | 2.09 | 0.53 | 25.4 | 12.2 | 1.24 | .267 | 3.63 | 6.59 |
| 2 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 3 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 4 |  | B. Blyleven | 3,560 | 664 | 276 | 241 | .534 | 659 | 3.32 | 236 | 58 | 0 | 4797.0 | 4,485 | 1,772 | 1,963 | 413 | 1,273 | 152 | 2 | 65 | 19,785 | 112 | 6.68 | 2.39 | 2.80 | 0.77 | 18.0 | 6.4 | 1.20 | .283 | 3.68 | 8.41 |
| 5 |  | G. Maddux | 3,371 | 744 | 355 | 227 | .610 | 740 | 3.16 | 109 | 35 | 0 | 5008.1 | 4,726 | 1,756 | 1,981 | 353 | 999 | 137 | 3 | 177 | 20,421 | 70 | 6.06 | 1.80 | 3.37 | 0.63 | 16.5 | 4.9 | 1.14 | .281 | 3.56 | 8.49 |
| 6 |  | S. Carlton | 3,353 | 587 | 271 | 191 | .587 | 572 | 3.27 | 205 | 43 | 1 | 4216.2 | 3,770 | 1,533 | 1,751 | 346 | 1,480 | 40 | 6 | 121 | 17,509 | 143 | 7.16 | 3.16 | 2.27 | 0.74 | 19.2 | 8.5 | 1.25 | .279 | 3.74 | 8.05 |
| 7 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 8 | | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 9 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 10 |  | CC Sabathia | 2,862 | 514 | 239 | 146 | .621 | 514 | 3.69 | 38 | 12 | 0 | 3343.1 | 3,162 | 1,369 | 1,496 | 339 | 1,014 | 111 | 0 | 44 | 13,964 | 72 | 7.70 | 2.73 | 2.82 | 0.91 | 20.5 | 7.3 | 1.25 | .293 | 4.03 | 8.51 |
| 11 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 12 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 13 |  | T. Seaver | 2,770 | 511 | 235 | 161 | .593 | 506 | 2.97 | 161 | 47 | 0 | 3685.0 | 3,087 | 1,216 | 1,336 | 301 | 1,095 | 52 | 2 | 89 | 14,968 | 99 | 6.77 | 2.67 | 2.53 | 0.74 | 18.5 | 7.3 | 1.13 | .259 | 3.26 | 7.54 |
| 14 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 15 | | P. Niekro | 2,637 | 627 | 252 | 216 | .538 | 593 | 3.46 | 189 | 32 | 9 | 4281.1 | 4,054 | 1,646 | 1,895 | 385 | 1,526 | 94 | 22 | 63 | 18,072 | 156 | 5.54 | 3.21 | 1.73 | 0.81 | 14.6 | 8.4 | 1.30 | .273 | 3.98 | 8.52 |
| 16 | | D. Sutton | 2,612 | 585 | 258 | 182 | .586 | 580 | 3.21 | 132 | 43 | 3 | 4054.2 | 3,572 | 1,445 | 1,600 | 366 | 1,005 | 58 | 4 | 60 | 16,539 | 82 | 5.80 | 2.23 | 2.60 | 0.81 | 15.8 | 6.1 | 1.13 | .257 | 3.55 | 7.93 |
| 17 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 18 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 19 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 20 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 21 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 22 |  | B. Colon | 2,475 | 543 | 241 | 176 | .578 | 532 | 4.03 | 37 | 13 | 0 | 3346.2 | 3,445 | 1,500 | 1,632 | 411 | 926 | 62 | 2 | 46 | 14,145 | 43 | 6.66 | 2.49 | 2.67 | 1.11 | 17.5 | 6.5 | 1.31 | .295 | 4.39 | 9.26 |
| 23 |  | J. Verlander | 2,464 | 391 | 192 | 114 | .627 | 391 | 3.43 | 23 | 7 | 0 | 2584.2 | 2,263 | 985 | 1,068 | 248 | 779 | 86 | 0 | 27 | 10,661 | 79 | 8.58 | 2.71 | 3.16 | 0.86 | 23.1 | 7.3 | 1.18 | .284 | 3.72 | 7.88 |
| 24 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 25 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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