Between April 11, 1968 and September 22, 2007, Nolan Ryan struck out the most batters, with 5,708 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,708 | 805 | 324 | 291 | .527 | 772 | 3.19 | 222 | 61 | 3 | 5383.0 | 3,918 | 1,906 | 2,173 | 320 | 2,792 | 158 | 13 | 77 | 22,558 | 276 | 9.54 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.63 | 6.55 |
| 2 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 3 |  | R. Johnson | 4,616 | 566 | 284 | 150 | .654 | 556 | 3.22 | 98 | 37 | 2 | 3855.1 | 3,065 | 1,381 | 1,556 | 368 | 1,422 | 182 | 5 | 29 | 15,877 | 102 | 10.78 | 3.32 | 3.25 | 0.86 | 29.1 | 9.0 | 1.16 | .290 | 3.63 | 7.16 |
| 4 |  | S. Carlton | 3,922 | 687 | 312 | 232 | .574 | 670 | 3.23 | 241 | 52 | 1 | 4947.2 | 4,416 | 1,775 | 2,030 | 399 | 1,745 | 50 | 7 | 147 | 20,553 | 170 | 7.13 | 3.17 | 2.25 | 0.73 | 19.1 | 8.5 | 1.25 | .278 | 3.69 | 8.03 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,467 | 620 | 295 | 192 | .606 | 612 | 2.87 | 213 | 59 | 1 | 4523.2 | 3,740 | 1,441 | 1,585 | 360 | 1,312 | 71 | 5 | 111 | 18,308 | 120 | 6.90 | 2.61 | 2.64 | 0.72 | 18.9 | 7.2 | 1.12 | .258 | 3.15 | 7.44 |
| 7 |  | G. Maddux | 3,269 | 709 | 346 | 213 | .619 | 705 | 3.10 | 109 | 35 | 0 | 4805.2 | 4,508 | 1,657 | 1,868 | 331 | 967 | 130 | 3 | 172 | 19,575 | 68 | 6.12 | 1.81 | 3.38 | 0.62 | 16.7 | 4.9 | 1.14 | .281 | 3.50 | 8.44 |
| 8 | | D. Sutton | 3,196 | 700 | 301 | 229 | .568 | 687 | 3.24 | 161 | 53 | 4 | 4824.0 | 4,277 | 1,737 | 1,916 | 435 | 1,234 | 73 | 10 | 88 | 19,753 | 104 | 5.96 | 2.30 | 2.59 | 0.81 | 16.2 | 6.2 | 1.14 | .259 | 3.57 | 7.98 |
| 9 | | P. Niekro | 3,139 | 739 | 301 | 259 | .538 | 695 | 3.41 | 235 | 44 | 12 | 5057.0 | 4,744 | 1,914 | 2,199 | 463 | 1,698 | 110 | 30 | 75 | 21,236 | 195 | 5.59 | 3.02 | 1.85 | 0.82 | 14.8 | 8.0 | 1.27 | .271 | 3.91 | 8.44 |
| 10 | | C. Schilling | 3,110 | 568 | 215 | 146 | .596 | 435 | 3.46 | 83 | 20 | 22 | 3255.0 | 2,992 | 1,252 | 1,317 | 346 | 711 | 52 | 81 | 43 | 13,261 | 72 | 8.60 | 1.97 | 4.37 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 11 |  | P. Martinez | 3,022 | 446 | 209 | 92 | .694 | 379 | 2.80 | 46 | 17 | 3 | 2666.2 | 2,039 | 831 | 915 | 213 | 707 | 131 | 23 | 27 | 10,680 | 60 | 10.20 | 2.39 | 4.27 | 0.72 | 28.3 | 6.6 | 1.03 | .276 | 3.09 | 6.88 |
| 12 |  | J. Smoltz | 2,967 | 701 | 207 | 144 | .590 | 460 | 3.25 | 53 | 16 | 154 | 3363.0 | 2,947 | 1,216 | 1,322 | 273 | 984 | 54 | 204 | 81 | 13,790 | 142 | 7.94 | 2.63 | 3.02 | 0.73 | 21.5 | 7.1 | 1.17 | .281 | 3.54 | 7.89 |
| 13 | | F. Jenkins | 2,796 | 558 | 256 | 204 | .557 | 544 | 3.38 | 245 | 45 | 1 | 4014.2 | 3,755 | 1,508 | 1,672 | 428 | 860 | 77 | 9 | 96 | 16,446 | 59 | 6.27 | 1.93 | 3.25 | 0.96 | 17.0 | 5.2 | 1.15 | .271 | 3.75 | 8.42 |
| 14 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 15 | | G. Perry | 2,706 | 567 | 254 | 210 | .547 | 562 | 3.08 | 260 | 45 | 2 | 4280.1 | 3,954 | 1,463 | 1,698 | 314 | 1,099 | 86 | 5 | 113 | 17,526 | 117 | 5.69 | 2.31 | 2.46 | 0.66 | 15.4 | 6.3 | 1.18 | .273 | 3.57 | 8.31 |
| 16 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 17 | | M. Mussina | 2,656 | 501 | 249 | 144 | .634 | 500 | 3.69 | 57 | 23 | 0 | 3350.1 | 3,228 | 1,374 | 1,465 | 359 | 752 | 52 | 0 | 26 | 13,722 | 67 | 7.13 | 2.02 | 3.53 | 0.96 | 19.4 | 5.5 | 1.19 | .290 | 3.94 | 8.67 |
| 18 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 19 | | T. Glavine | 2,566 | 667 | 303 | 197 | .606 | 667 | 3.48 | 56 | 25 | 0 | 4344.2 | 4,217 | 1,682 | 1,847 | 342 | 1,460 | 64 | 0 | 141 | 18,290 | 65 | 5.32 | 3.02 | 1.76 | 0.71 | 14.0 | 8.0 | 1.31 | .280 | 3.83 | 8.74 |
| 20 | | J. Koosman | 2,545 | 603 | 222 | 207 | .517 | 524 | 3.34 | 140 | 33 | 17 | 3817.0 | 3,613 | 1,418 | 1,591 | 287 | 1,179 | 71 | 42 | 117 | 15,891 | 89 | 6.00 | 2.78 | 2.16 | 0.68 | 16.0 | 7.4 | 1.26 | .282 | 3.75 | 8.52 |
| 21 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 22 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 23 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 24 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 25 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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