Between April 15, 1985 and August 29, 2016, Randy Johnson struck out the most hitters, with 4,875 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 2 |  | R. Clemens | 4,541 | 687 | 344 | 180 | .656 | 686 | 3.09 | 113 | 45 | 0 | 4777.1 | 4,033 | 1,639 | 1,814 | 349 | 1,548 | 157 | 0 | 60 | 19,640 | 139 | 8.55 | 2.92 | 2.93 | 0.66 | 23.1 | 7.9 | 1.17 | .282 | 3.42 | 7.60 |
| 3 |  | G. Maddux | 3,371 | 744 | 355 | 227 | .610 | 740 | 3.16 | 109 | 35 | 0 | 5008.1 | 4,726 | 1,756 | 1,981 | 353 | 999 | 137 | 3 | 177 | 20,421 | 70 | 6.06 | 1.80 | 3.37 | 0.63 | 16.5 | 4.9 | 1.14 | .281 | 3.56 | 8.49 |
| 4 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 5 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 6 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | CC Sabathia | 2,699 | 476 | 222 | 140 | .613 | 476 | 3.72 | 38 | 12 | 0 | 3132.2 | 2,971 | 1,294 | 1,413 | 309 | 948 | 103 | 0 | 43 | 13,088 | 66 | 7.75 | 2.72 | 2.85 | 0.89 | 20.6 | 7.2 | 1.25 | .295 | 4.06 | 8.54 |
| 9 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 10 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 11 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 12 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 13 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 14 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 15 | | J. Moyer | 2,441 | 696 | 269 | 209 | .563 | 638 | 4.25 | 33 | 10 | 0 | 4074.0 | 4,231 | 1,926 | 2,076 | 522 | 1,155 | 146 | 15 | 69 | 17,356 | 57 | 5.39 | 2.55 | 2.11 | 1.15 | 14.1 | 6.7 | 1.32 | .283 | 4.59 | 9.35 |
| 16 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 17 |  | B. Colon | 2,340 | 502 | 230 | 161 | .588 | 493 | 3.94 | 36 | 13 | 0 | 3132.1 | 3,191 | 1,372 | 1,494 | 373 | 884 | 59 | 1 | 46 | 13,219 | 42 | 6.72 | 2.54 | 2.65 | 1.07 | 17.7 | 6.7 | 1.30 | .295 | 4.29 | 9.17 |
| 18 | | M. Langston | 2,259 | 421 | 161 | 148 | .521 | 394 | 4.01 | 76 | 16 | 0 | 2730.1 | 2,529 | 1,217 | 1,335 | 294 | 1,167 | 38 | 3 | 29 | 11,566 | 85 | 7.45 | 3.85 | 1.94 | 0.97 | 19.5 | 10.1 | 1.35 | .286 | 4.40 | 8.34 |
| 19 |  | F. Hernandez | 2,243 | 352 | 152 | 105 | .591 | 352 | 3.12 | 25 | 11 | 0 | 2380.0 | 2,116 | 824 | 917 | 197 | 678 | 80 | 0 | 16 | 9,744 | 130 | 8.48 | 2.56 | 3.31 | 0.74 | 23.0 | 7.0 | 1.17 | .293 | 3.47 | 8.00 |
| 20 | | J. Peavy | 2,206 | 386 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2375.0 | 2,132 | 959 | 1,010 | 259 | 706 | 78 | 3 | 42 | 9,829 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.19 | .285 | 3.83 | 8.08 |
| 21 | | D. Wells | 2,201 | 660 | 239 | 157 | .604 | 489 | 4.13 | 54 | 12 | 13 | 3439.0 | 3,635 | 1,578 | 1,702 | 407 | 719 | 83 | 65 | 65 | 14,413 | 101 | 5.76 | 1.88 | 3.06 | 1.07 | 15.3 | 5.0 | 1.27 | .293 | 4.45 | 9.51 |
| 22 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 23 |  | J. Verlander | 2,132 | 345 | 171 | 104 | .622 | 345 | 3.50 | 23 | 7 | 0 | 2292.1 | 2,039 | 892 | 971 | 210 | 688 | 79 | 0 | 22 | 9,483 | 73 | 8.37 | 2.70 | 3.10 | 0.82 | 22.5 | 7.3 | 1.19 | .287 | 3.81 | 8.01 |
| 24 | | J. Lackey | 2,121 | 412 | 174 | 134 | .565 | 411 | 3.89 | 18 | 8 | 0 | 2639.2 | 2,673 | 1,140 | 1,243 | 279 | 752 | 121 | 0 | 29 | 11,178 | 113 | 7.23 | 2.56 | 2.82 | 0.95 | 19.0 | 6.7 | 1.30 | .303 | 4.24 | 9.11 |
| 25 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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