Between April 24, 1987 and April 15, 2016, Randy Johnson struck out the most hitters, with 4,875 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 2 |  | R. Clemens | 4,216 | 637 | 313 | 169 | .649 | 636 | 3.12 | 99 | 42 | 0 | 4410.2 | 3,762 | 1,530 | 1,695 | 322 | 1,441 | 148 | 0 | 59 | 18,178 | 127 | 8.60 | 2.94 | 2.93 | 0.66 | 23.2 | 7.9 | 1.18 | .285 | 3.46 | 7.68 |
| 3 |  | G. Maddux | 3,338 | 734 | 353 | 221 | .615 | 732 | 3.13 | 108 | 35 | 0 | 4956.2 | 4,658 | 1,722 | 1,946 | 350 | 978 | 136 | 2 | 175 | 20,184 | 67 | 6.06 | 1.78 | 3.41 | 0.64 | 16.5 | 4.8 | 1.14 | .280 | 3.53 | 8.46 |
| 4 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 5 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 6 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 | | D. Cone | 2,638 | 435 | 194 | 125 | .608 | 419 | 3.44 | 56 | 22 | 1 | 2866.1 | 2,464 | 1,097 | 1,203 | 255 | 1,119 | 105 | 3 | 41 | 12,032 | 146 | 8.28 | 3.51 | 2.36 | 0.80 | 21.9 | 9.3 | 1.25 | .279 | 3.78 | 7.74 |
| 9 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 10 |  | CC Sabathia | 2,577 | 453 | 215 | 129 | .625 | 453 | 3.69 | 38 | 12 | 0 | 2994.2 | 2,835 | 1,228 | 1,343 | 293 | 898 | 95 | 0 | 42 | 12,490 | 65 | 7.74 | 2.70 | 2.87 | 0.88 | 20.6 | 7.2 | 1.25 | .295 | 4.04 | 8.52 |
| 11 | | C. Finley | 2,560 | 495 | 197 | 172 | .534 | 467 | 3.86 | 63 | 15 | 0 | 3139.1 | 3,023 | 1,348 | 1,499 | 302 | 1,303 | 75 | 15 | 35 | 13,394 | 127 | 7.34 | 3.74 | 1.96 | 0.87 | 19.1 | 9.7 | 1.38 | .297 | 4.30 | 8.67 |
| 12 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 13 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 14 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 15 | | K. Brown | 2,393 | 485 | 210 | 144 | .593 | 475 | 3.27 | 72 | 17 | 0 | 3251.1 | 3,073 | 1,183 | 1,355 | 208 | 901 | 139 | 1 | 42 | 13,523 | 108 | 6.62 | 2.49 | 2.66 | 0.58 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 16 | | J. Moyer | 2,377 | 677 | 261 | 204 | .561 | 620 | 4.24 | 32 | 9 | 0 | 3971.2 | 4,114 | 1,872 | 2,019 | 512 | 1,106 | 143 | 15 | 67 | 16,901 | 54 | 5.39 | 2.51 | 2.15 | 1.16 | 14.1 | 6.5 | 1.31 | .282 | 4.58 | 9.32 |
| 17 |  | B. Colon | 2,250 | 478 | 219 | 155 | .586 | 469 | 3.96 | 36 | 13 | 0 | 2993.1 | 3,043 | 1,317 | 1,432 | 356 | 857 | 57 | 1 | 44 | 12,640 | 42 | 6.77 | 2.58 | 2.63 | 1.07 | 17.8 | 6.8 | 1.30 | .295 | 4.31 | 9.15 |
| 18 | | D. Wells | 2,201 | 660 | 239 | 157 | .604 | 489 | 4.13 | 54 | 12 | 13 | 3439.0 | 3,635 | 1,578 | 1,702 | 407 | 719 | 83 | 65 | 65 | 14,413 | 101 | 5.76 | 1.88 | 3.06 | 1.07 | 15.3 | 5.0 | 1.27 | .293 | 4.45 | 9.51 |
| 19 |  | F. Hernandez | 2,158 | 336 | 143 | 102 | .584 | 336 | 3.10 | 25 | 11 | 0 | 2275.1 | 2,023 | 784 | 873 | 184 | 637 | 72 | 0 | 16 | 9,304 | 126 | 8.54 | 2.52 | 3.39 | 0.73 | 23.2 | 6.8 | 1.17 | .294 | 3.45 | 8.00 |
| 20 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 21 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 22 | | J. Peavy | 2,113 | 359 | 147 | 118 | .555 | 358 | 3.56 | 15 | 6 | 0 | 2267.1 | 2,021 | 897 | 945 | 242 | 673 | 76 | 0 | 42 | 9,365 | 42 | 8.39 | 2.67 | 3.14 | 0.96 | 22.6 | 7.2 | 1.19 | .284 | 3.75 | 8.02 |
| 23 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 24 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 25 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
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| NL Central | W | L | PCT | GB |
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 Astros - y | 81 | 81 | .500 | |
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