Between April 25, 1966 and September 27, 2004, Nolan Ryan struck out the most batters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | R. Clemens | 4,309 | 639 | 328 | 164 | .667 | 638 | 3.18 | 117 | 46 | 0 | 4487.0 | 3,841 | 1,584 | 1,744 | 335 | 1,457 | 147 | 0 | 57 | 18,508 | 130 | 8.64 | 2.92 | 2.96 | 0.67 | 23.3 | 7.9 | 1.18 | .286 | 3.50 | 7.70 |
| 3 |  | R. Johnson | 4,153 | 488 | 245 | 128 | .657 | 478 | 3.07 | 92 | 37 | 2 | 3360.0 | 2,602 | 1,147 | 1,297 | 300 | 1,302 | 156 | 5 | 23 | 13,829 | 95 | 11.12 | 3.49 | 3.19 | 0.80 | 30.0 | 9.4 | 1.16 | .291 | 3.47 | 6.97 |
| 4 |  | S. Carlton | 4,115 | 726 | 329 | 244 | .574 | 707 | 3.22 | 254 | 55 | 2 | 5192.2 | 4,645 | 1,857 | 2,123 | 411 | 1,825 | 52 | 8 | 149 | 21,578 | 178 | 7.13 | 3.16 | 2.25 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,557 | 771 | 323 | 254 | .560 | 753 | 3.26 | 178 | 58 | 5 | 5260.1 | 4,670 | 1,907 | 2,096 | 471 | 1,340 | 82 | 12 | 103 | 21,539 | 112 | 6.09 | 2.29 | 2.65 | 0.81 | 16.5 | 6.2 | 1.14 | .261 | 3.59 | 7.99 |
| 8 | | P. Niekro | 3,284 | 809 | 315 | 271 | .538 | 715 | 3.35 | 245 | 45 | 23 | 5307.1 | 4,951 | 1,977 | 2,292 | 475 | 1,774 | 119 | 58 | 82 | 22,260 | 217 | 5.57 | 3.01 | 1.85 | 0.81 | 14.8 | 8.0 | 1.27 | .270 | 3.89 | 8.40 |
| 9 | | F. Jenkins | 3,176 | 655 | 281 | 225 | .555 | 594 | 3.34 | 267 | 49 | 6 | 4480.2 | 4,128 | 1,665 | 1,848 | 482 | 994 | 84 | 31 | 116 | 18,326 | 62 | 6.38 | 2.00 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.29 |
| 10 | | G. Perry | 3,126 | 640 | 288 | 235 | .551 | 633 | 3.05 | 290 | 51 | 3 | 4817.1 | 4,422 | 1,632 | 1,886 | 349 | 1,221 | 95 | 7 | 132 | 19,697 | 137 | 5.84 | 2.28 | 2.56 | 0.65 | 15.9 | 6.2 | 1.17 | .273 | 3.52 | 8.26 |
| 11 |  | G. Maddux | 2,906 | 606 | 304 | 173 | .637 | 602 | 2.93 | 105 | 35 | 0 | 4170.1 | 3,830 | 1,358 | 1,551 | 264 | 868 | 116 | 3 | 158 | 16,939 | 55 | 6.27 | 1.87 | 3.35 | 0.57 | 17.2 | 5.1 | 1.13 | .279 | 3.35 | 8.27 |
| 12 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 13 | | C. Schilling | 2,745 | 482 | 184 | 123 | .599 | 370 | 3.32 | 82 | 19 | 13 | 2812.2 | 2,492 | 1,039 | 1,101 | 286 | 638 | 44 | 60 | 41 | 11,399 | 70 | 8.78 | 2.04 | 4.30 | 0.92 | 24.1 | 5.6 | 1.11 | .287 | 3.52 | 7.97 |
| 14 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 15 |  | P. Martinez | 2,648 | 387 | 182 | 75 | .708 | 320 | 2.69 | 42 | 16 | 3 | 2291.0 | 1,736 | 686 | 760 | 175 | 614 | 114 | 23 | 21 | 9,162 | 53 | 10.40 | 2.41 | 4.31 | 0.69 | 28.9 | 6.7 | 1.03 | .278 | 2.99 | 6.82 |
| 16 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 17 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 18 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 19 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 20 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 21 |  | J. Smoltz | 2,393 | 599 | 163 | 121 | .574 | 361 | 3.28 | 47 | 14 | 151 | 2696.1 | 2,326 | 982 | 1,074 | 216 | 828 | 40 | 201 | 61 | 11,054 | 128 | 7.99 | 2.76 | 2.89 | 0.72 | 21.6 | 7.5 | 1.17 | .278 | 3.58 | 7.76 |
| 22 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 23 | | K. Brown | 2,345 | 472 | 207 | 136 | .603 | 462 | 3.21 | 72 | 17 | 0 | 3178.0 | 2,971 | 1,132 | 1,299 | 203 | 880 | 132 | 1 | 41 | 13,177 | 102 | 6.64 | 2.49 | 2.66 | 0.57 | 17.8 | 6.7 | 1.21 | .288 | 3.68 | 8.41 |
| 24 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 25 | | M. Lolich | 2,292 | 463 | 178 | 163 | .522 | 405 | 3.44 | 171 | 32 | 5 | 3001.1 | 2,792 | 1,147 | 1,273 | 281 | 902 | 69 | 25 | 64 | 12,484 | 102 | 6.87 | 2.70 | 2.54 | 0.84 | 18.4 | 7.2 | 1.23 | .281 | 3.82 | 8.37 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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