Between April 27, 1962 and May 2, 2004, Nolan Ryan struck out the most hitters, with 5,714 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | S. Carlton | 4,136 | 741 | 329 | 244 | .574 | 709 | 3.22 | 254 | 55 | 2 | 5217.2 | 4,672 | 1,864 | 2,130 | 414 | 1,833 | 53 | 13 | 150 | 21,682 | 183 | 7.13 | 3.16 | 2.26 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.67 | 8.06 |
| 3 |  | R. Clemens | 4,131 | 612 | 315 | 160 | .663 | 611 | 3.18 | 117 | 46 | 0 | 4311.0 | 3,698 | 1,524 | 1,680 | 324 | 1,393 | 142 | 0 | 53 | 17,779 | 125 | 8.62 | 2.91 | 2.97 | 0.68 | 23.2 | 7.8 | 1.18 | .286 | 3.51 | 7.72 |
| 4 |  | R. Johnson | 3,922 | 460 | 233 | 116 | .668 | 450 | 3.10 | 89 | 36 | 2 | 3163.0 | 2,462 | 1,091 | 1,232 | 286 | 1,270 | 149 | 5 | 22 | 13,063 | 93 | 11.16 | 3.61 | 3.09 | 0.81 | 30.0 | 9.7 | 1.18 | .293 | 3.51 | 7.01 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 8 | | G. Perry | 3,532 | 775 | 313 | 265 | .542 | 688 | 3.10 | 303 | 53 | 10 | 5342.1 | 4,926 | 1,840 | 2,122 | 399 | 1,375 | 108 | 33 | 162 | 21,915 | 158 | 5.95 | 2.32 | 2.57 | 0.67 | 16.1 | 6.3 | 1.18 | .274 | 3.57 | 8.30 |
| 9 | | P. Niekro | 3,342 | 864 | 318 | 274 | .537 | 716 | 3.35 | 245 | 45 | 29 | 5404.0 | 5,044 | 2,012 | 2,337 | 482 | 1,809 | 123 | 83 | 86 | 22,677 | 227 | 5.57 | 3.01 | 1.85 | 0.80 | 14.7 | 8.0 | 1.27 | .270 | 3.89 | 8.40 |
| 10 | | F. Jenkins | 3,191 | 664 | 284 | 226 | .557 | 594 | 3.34 | 267 | 49 | 7 | 4500.2 | 4,142 | 1,669 | 1,853 | 484 | 997 | 84 | 37 | 117 | 18,404 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.28 |
| 11 | | M. Lolich | 2,832 | 586 | 217 | 191 | .532 | 496 | 3.44 | 195 | 41 | 10 | 3638.1 | 3,366 | 1,390 | 1,537 | 347 | 1,099 | 91 | 40 | 67 | 15,139 | 123 | 7.01 | 2.72 | 2.58 | 0.86 | 18.7 | 7.3 | 1.23 | .280 | 3.80 | 8.33 |
| 12 |  | B. Gibson | 2,819 | 450 | 231 | 150 | .606 | 431 | 2.80 | 240 | 53 | 5 | 3493.0 | 2,911 | 1,088 | 1,221 | 231 | 1,121 | 94 | 12 | 103 | 14,347 | 91 | 7.26 | 2.89 | 2.51 | 0.60 | 19.6 | 7.8 | 1.15 | .266 | 3.15 | 7.50 |
| 13 |  | G. Maddux | 2,785 | 580 | 290 | 165 | .637 | 576 | 2.91 | 103 | 34 | 0 | 3997.1 | 3,658 | 1,293 | 1,479 | 242 | 850 | 113 | 3 | 155 | 16,248 | 53 | 6.27 | 1.91 | 3.28 | 0.54 | 17.1 | 5.2 | 1.13 | .279 | 3.33 | 8.24 |
| 14 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 15 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 16 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 17 | | C. Schilling | 2,581 | 455 | 166 | 118 | .585 | 343 | 3.33 | 79 | 19 | 13 | 2621.1 | 2,322 | 970 | 1,030 | 266 | 609 | 40 | 60 | 41 | 10,636 | 67 | 8.86 | 2.09 | 4.24 | 0.91 | 24.3 | 5.7 | 1.12 | .288 | 3.54 | 7.97 |
| 18 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 19 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 20 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 21 |  | P. Martinez | 2,457 | 361 | 169 | 69 | .710 | 294 | 2.61 | 41 | 15 | 3 | 2115.2 | 1,590 | 614 | 686 | 154 | 565 | 101 | 23 | 21 | 8,442 | 51 | 10.45 | 2.40 | 4.35 | 0.66 | 29.1 | 6.7 | 1.02 | .278 | 2.92 | 6.76 |
| 22 | | S. McDowell | 2,445 | 422 | 140 | 134 | .511 | 344 | 3.18 | 103 | 23 | 14 | 2477.1 | 1,941 | 876 | 996 | 164 | 1,300 | 59 | 39 | 72 | 10,526 | 141 | 8.88 | 4.72 | 1.88 | 0.60 | 23.2 | 12.4 | 1.31 | .271 | 3.62 | 7.05 |
| 23 | | L. Tiant | 2,416 | 573 | 229 | 172 | .571 | 484 | 3.30 | 187 | 49 | 15 | 3486.1 | 3,075 | 1,280 | 1,400 | 346 | 1,104 | 49 | 51 | 53 | 14,366 | 27 | 6.24 | 2.85 | 2.19 | 0.89 | 16.8 | 7.7 | 1.20 | .261 | 3.61 | 7.94 |
| 24 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 25 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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