Between August 28, 1972 and August 4, 2007, Nolan Ryan struck out the most hitters, with 4,988 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 4,988 | 672 | 281 | 242 | .537 | 669 | 3.18 | 196 | 51 | 1 | 4669.2 | 3,430 | 1,649 | 1,886 | 275 | 2,328 | 125 | 3 | 61 | 19,501 | 241 | 9.61 | 4.49 | 2.14 | 0.53 | 25.6 | 11.9 | 1.23 | .268 | 3.63 | 6.61 |
| 2 |  | R. Clemens | 4,647 | 703 | 351 | 183 | .657 | 701 | 3.12 | 118 | 46 | 0 | 4883.2 | 4,155 | 1,692 | 1,869 | 359 | 1,567 | 155 | 0 | 63 | 20,099 | 142 | 8.56 | 2.89 | 2.97 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.44 | 7.66 |
| 3 |  | R. Johnson | 4,616 | 566 | 284 | 150 | .654 | 556 | 3.22 | 98 | 37 | 2 | 3855.1 | 3,065 | 1,381 | 1,556 | 368 | 1,422 | 182 | 5 | 29 | 15,877 | 102 | 10.78 | 3.32 | 3.25 | 0.86 | 29.1 | 9.0 | 1.16 | .290 | 3.63 | 7.16 |
| 4 |  | G. Maddux | 3,240 | 700 | 340 | 211 | .617 | 696 | 3.10 | 109 | 35 | 0 | 4753.1 | 4,453 | 1,638 | 1,849 | 328 | 965 | 129 | 3 | 172 | 19,363 | 66 | 6.13 | 1.83 | 3.36 | 0.62 | 16.7 | 5.0 | 1.14 | .281 | 3.50 | 8.43 |
| 5 |  | B. Blyleven | 3,179 | 597 | 251 | 211 | .543 | 593 | 3.36 | 215 | 52 | 0 | 4315.0 | 4,031 | 1,610 | 1,788 | 374 | 1,163 | 141 | 1 | 60 | 17,816 | 101 | 6.63 | 2.43 | 2.73 | 0.78 | 17.8 | 6.5 | 1.20 | .282 | 3.73 | 8.41 |
| 6 | | C. Schilling | 3,086 | 560 | 213 | 142 | .600 | 427 | 3.46 | 83 | 20 | 22 | 3204.1 | 2,942 | 1,232 | 1,296 | 338 | 707 | 52 | 81 | 43 | 13,055 | 72 | 8.67 | 1.99 | 4.36 | 0.95 | 23.6 | 5.4 | 1.14 | .294 | 3.64 | 8.26 |
| 7 |  | P. Martinez | 2,998 | 442 | 206 | 92 | .691 | 375 | 2.81 | 46 | 17 | 3 | 2645.2 | 2,013 | 825 | 907 | 213 | 701 | 129 | 23 | 26 | 10,582 | 59 | 10.20 | 2.38 | 4.28 | 0.72 | 28.3 | 6.6 | 1.03 | .275 | 3.09 | 6.85 |
| 8 |  | S. Carlton | 2,929 | 519 | 231 | 175 | .569 | 505 | 3.33 | 166 | 32 | 1 | 3683.0 | 3,309 | 1,364 | 1,566 | 311 | 1,316 | 35 | 6 | 104 | 15,327 | 126 | 7.16 | 3.22 | 2.23 | 0.76 | 19.1 | 8.6 | 1.26 | .279 | 3.83 | 8.09 |
| 9 |  | J. Smoltz | 2,900 | 691 | 203 | 143 | .587 | 450 | 3.26 | 53 | 16 | 154 | 3294.2 | 2,894 | 1,195 | 1,300 | 268 | 967 | 52 | 204 | 80 | 13,519 | 141 | 7.92 | 2.64 | 3.00 | 0.73 | 21.5 | 7.2 | 1.17 | .281 | 3.55 | 7.91 |
| 10 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 11 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 12 | | M. Mussina | 2,636 | 493 | 245 | 141 | .635 | 493 | 3.67 | 57 | 23 | 0 | 3310.2 | 3,171 | 1,349 | 1,439 | 357 | 743 | 51 | 0 | 26 | 13,543 | 66 | 7.17 | 2.02 | 3.55 | 0.97 | 19.5 | 5.5 | 1.18 | .288 | 3.91 | 8.62 |
| 13 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 14 | | T. Glavine | 2,543 | 658 | 299 | 197 | .603 | 658 | 3.49 | 56 | 25 | 0 | 4287.1 | 4,153 | 1,663 | 1,828 | 340 | 1,448 | 64 | 0 | 141 | 18,052 | 65 | 5.34 | 3.04 | 1.76 | 0.71 | 14.1 | 8.0 | 1.31 | .279 | 3.84 | 8.72 |
| 15 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 16 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 17 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 18 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 19 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 20 | | P. Niekro | 2,335 | 555 | 225 | 192 | .540 | 529 | 3.52 | 158 | 28 | 7 | 3789.0 | 3,608 | 1,482 | 1,696 | 341 | 1,422 | 88 | 17 | 54 | 16,069 | 144 | 5.55 | 3.38 | 1.64 | 0.81 | 14.5 | 8.8 | 1.33 | .275 | 4.03 | 8.57 |
| 21 |  | T. Seaver | 2,299 | 449 | 200 | 142 | .585 | 445 | 3.08 | 131 | 41 | 0 | 3195.1 | 2,702 | 1,093 | 1,201 | 266 | 976 | 44 | 1 | 86 | 13,039 | 91 | 6.48 | 2.75 | 2.36 | 0.75 | 17.6 | 7.5 | 1.15 | .258 | 3.38 | 7.61 |
| 22 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 23 | | D. Sutton | 2,270 | 522 | 227 | 163 | .582 | 518 | 3.31 | 109 | 33 | 2 | 3586.2 | 3,199 | 1,319 | 1,455 | 345 | 911 | 51 | 3 | 54 | 14,698 | 72 | 5.70 | 2.29 | 2.49 | 0.87 | 15.4 | 6.2 | 1.15 | .257 | 3.65 | 8.03 |
| 24 | | D. Wells | 2,181 | 652 | 235 | 155 | .603 | 481 | 4.10 | 54 | 12 | 13 | 3396.1 | 3,579 | 1,549 | 1,672 | 401 | 710 | 83 | 65 | 64 | 14,228 | 100 | 5.78 | 1.88 | 3.07 | 1.06 | 15.3 | 5.0 | 1.26 | .293 | 4.43 | 9.48 |
| 25 | | D. Martinez | 2,149 | 692 | 245 | 193 | .559 | 562 | 3.70 | 122 | 30 | 8 | 3999.2 | 3,897 | 1,643 | 1,835 | 372 | 1,165 | 122 | 51 | 70 | 16,754 | 84 | 4.84 | 2.62 | 1.84 | 0.84 | 12.8 | 7.0 | 1.27 | .272 | 4.13 | 8.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
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 Astros - y | 81 | 81 | .500 | |
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