Between August 29, 1972 and May 6, 2001, Nolan Ryan struck out the most hitters, with 4,988 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 4,988 | 672 | 281 | 242 | .537 | 669 | 3.18 | 196 | 51 | 1 | 4669.2 | 3,430 | 1,649 | 1,886 | 275 | 2,328 | 125 | 3 | 61 | 19,501 | 241 | 9.61 | 4.49 | 2.14 | 0.53 | 25.6 | 11.9 | 1.23 | .268 | 3.63 | 6.61 |
| 2 |  | R. Clemens | 3,541 | 519 | 263 | 142 | .649 | 518 | 3.09 | 116 | 45 | 0 | 3713.2 | 3,147 | 1,276 | 1,411 | 264 | 1,201 | 125 | 0 | 44 | 15,290 | 96 | 8.58 | 2.91 | 2.95 | 0.64 | 23.2 | 7.9 | 1.17 | .284 | 3.42 | 7.63 |
| 3 |  | B. Blyleven | 3,179 | 597 | 251 | 211 | .543 | 593 | 3.36 | 215 | 52 | 0 | 4315.0 | 4,031 | 1,610 | 1,788 | 374 | 1,163 | 141 | 1 | 60 | 17,816 | 101 | 6.63 | 2.43 | 2.73 | 0.78 | 17.8 | 6.5 | 1.20 | .282 | 3.73 | 8.41 |
| 4 |  | R. Johnson | 3,112 | 373 | 182 | 98 | .650 | 364 | 3.20 | 78 | 29 | 2 | 2550.1 | 1,972 | 908 | 1,023 | 230 | 1,104 | 111 | 4 | 16 | 10,589 | 81 | 10.98 | 3.90 | 2.82 | 0.81 | 29.4 | 10.4 | 1.21 | .289 | 3.61 | 6.96 |
| 5 |  | S. Carlton | 2,929 | 519 | 231 | 175 | .569 | 505 | 3.33 | 166 | 32 | 1 | 3683.0 | 3,309 | 1,364 | 1,566 | 311 | 1,316 | 35 | 6 | 104 | 15,327 | 126 | 7.16 | 3.22 | 2.23 | 0.76 | 19.1 | 8.6 | 1.26 | .279 | 3.83 | 8.09 |
| 6 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 7 | | D. Cone | 2,540 | 420 | 184 | 116 | .613 | 390 | 3.40 | 56 | 22 | 1 | 2745.0 | 2,336 | 1,038 | 1,135 | 237 | 1,067 | 96 | 9 | 37 | 11,485 | 140 | 8.33 | 3.50 | 2.38 | 0.78 | 22.1 | 9.3 | 1.24 | .278 | 3.72 | 7.66 |
| 8 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 9 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 10 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 11 |  | G. Maddux | 2,388 | 477 | 243 | 137 | .639 | 473 | 2.82 | 100 | 32 | 0 | 3359.2 | 3,013 | 1,051 | 1,207 | 178 | 735 | 91 | 3 | 130 | 13,623 | 47 | 6.40 | 1.97 | 3.25 | 0.48 | 17.5 | 5.4 | 1.12 | .277 | 3.23 | 8.07 |
| 12 | | C. Finley | 2,376 | 477 | 184 | 153 | .546 | 420 | 3.77 | 61 | 14 | 0 | 2936.1 | 2,796 | 1,229 | 1,366 | 284 | 1,228 | 73 | 24 | 30 | 12,510 | 126 | 7.28 | 3.76 | 1.93 | 0.87 | 19.0 | 9.8 | 1.37 | .294 | 4.19 | 8.57 |
| 13 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 14 | | P. Niekro | 2,335 | 555 | 225 | 192 | .540 | 529 | 3.52 | 158 | 28 | 7 | 3789.0 | 3,608 | 1,482 | 1,696 | 341 | 1,422 | 88 | 17 | 54 | 16,069 | 144 | 5.55 | 3.38 | 1.64 | 0.81 | 14.5 | 8.8 | 1.33 | .275 | 4.03 | 8.57 |
| 15 |  | T. Seaver | 2,299 | 449 | 200 | 142 | .585 | 445 | 3.08 | 131 | 41 | 0 | 3195.1 | 2,702 | 1,093 | 1,201 | 266 | 976 | 44 | 1 | 86 | 13,039 | 91 | 6.48 | 2.75 | 2.36 | 0.75 | 17.6 | 7.5 | 1.15 | .258 | 3.38 | 7.61 |
| 16 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 17 | | D. Sutton | 2,270 | 522 | 227 | 163 | .582 | 518 | 3.31 | 109 | 33 | 2 | 3586.2 | 3,199 | 1,319 | 1,455 | 345 | 911 | 51 | 3 | 54 | 14,698 | 72 | 5.70 | 2.29 | 2.49 | 0.87 | 15.4 | 6.2 | 1.15 | .257 | 3.65 | 8.03 |
| 18 | | D. Martinez | 2,149 | 692 | 245 | 193 | .559 | 562 | 3.70 | 122 | 30 | 8 | 3999.2 | 3,897 | 1,643 | 1,835 | 372 | 1,165 | 122 | 51 | 70 | 16,754 | 84 | 4.84 | 2.62 | 1.84 | 0.84 | 12.8 | 7.0 | 1.27 | .272 | 4.13 | 8.77 |
| 19 |  | J. Smoltz | 2,098 | 356 | 157 | 113 | .581 | 356 | 3.35 | 47 | 14 | 0 | 2414.1 | 2,092 | 898 | 986 | 195 | 774 | 38 | 0 | 55 | 9,947 | 119 | 7.82 | 2.89 | 2.71 | 0.73 | 21.1 | 7.8 | 1.19 | .277 | 3.68 | 7.80 |
| 20 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 21 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 22 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 23 | | R. Reuschel | 1,956 | 543 | 208 | 185 | .529 | 517 | 3.38 | 99 | 24 | 5 | 3463.1 | 3,505 | 1,300 | 1,462 | 218 | 914 | 87 | 15 | 111 | 14,540 | 88 | 5.08 | 2.38 | 2.14 | 0.57 | 13.5 | 6.3 | 1.28 | .289 | 3.80 | 9.11 |
| 24 | | K. Brown | 1,947 | 387 | 174 | 115 | .602 | 385 | 3.19 | 72 | 17 | 0 | 2694.0 | 2,517 | 954 | 1,102 | 163 | 736 | 118 | 1 | 36 | 11,171 | 86 | 6.50 | 2.46 | 2.65 | 0.54 | 17.4 | 6.6 | 1.21 | .287 | 3.68 | 8.41 |
| 25 | | D. Darwin | 1,942 | 716 | 171 | 182 | .484 | 371 | 3.84 | 53 | 9 | 32 | 3016.2 | 2,951 | 1,286 | 1,432 | 321 | 874 | 81 | 171 | 101 | 12,716 | 52 | 5.79 | 2.61 | 2.22 | 0.96 | 15.3 | 6.9 | 1.27 | .277 | 4.27 | 8.80 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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