Between January 1, 1977 and April 28, 2005, Roger Clemens struck out the most hitters, with 4,349 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 4,349 | 644 | 329 | 164 | .667 | 643 | 3.16 | 117 | 46 | 0 | 4521.0 | 3,862 | 1,589 | 1,749 | 337 | 1,464 | 147 | 0 | 58 | 18,636 | 130 | 8.66 | 2.91 | 2.97 | 0.67 | 23.3 | 7.9 | 1.18 | .286 | 3.48 | 7.69 |
| 2 |  | R. Johnson | 4,195 | 494 | 248 | 129 | .658 | 484 | 3.08 | 92 | 37 | 2 | 3402.1 | 2,639 | 1,164 | 1,321 | 306 | 1,308 | 159 | 5 | 23 | 14,003 | 95 | 11.10 | 3.46 | 3.21 | 0.81 | 30.0 | 9.3 | 1.16 | .290 | 3.49 | 6.98 |
| 3 |  | N. Ryan | 3,629 | 513 | 202 | 176 | .534 | 513 | 3.24 | 106 | 31 | 0 | 3451.0 | 2,584 | 1,243 | 1,421 | 211 | 1,615 | 96 | 0 | 53 | 14,388 | 195 | 9.46 | 4.21 | 2.25 | 0.55 | 25.2 | 11.2 | 1.22 | .269 | 3.71 | 6.74 |
| 4 |  | G. Maddux | 2,929 | 612 | 305 | 175 | .635 | 608 | 2.96 | 105 | 35 | 0 | 4205.1 | 3,867 | 1,382 | 1,576 | 273 | 874 | 119 | 3 | 159 | 17,084 | 56 | 6.27 | 1.87 | 3.35 | 0.58 | 17.1 | 5.1 | 1.13 | .279 | 3.37 | 8.28 |
| 5 |  | C. Schilling | 2,765 | 485 | 185 | 125 | .597 | 373 | 3.35 | 82 | 19 | 13 | 2830.1 | 2,521 | 1,055 | 1,117 | 289 | 641 | 46 | 60 | 41 | 11,484 | 70 | 8.79 | 2.04 | 4.31 | 0.92 | 24.1 | 5.6 | 1.12 | .288 | 3.55 | 8.02 |
| 6 |  | P. Martinez | 2,699 | 393 | 184 | 77 | .705 | 326 | 2.71 | 43 | 16 | 3 | 2332.0 | 1,764 | 702 | 777 | 176 | 621 | 115 | 23 | 21 | 9,320 | 57 | 10.42 | 2.40 | 4.35 | 0.68 | 29.0 | 6.7 | 1.02 | .278 | 3.00 | 6.81 |
| 7 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 8 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 9 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 10 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 11 |  | J. Smoltz | 2,431 | 607 | 164 | 124 | .569 | 366 | 3.28 | 47 | 14 | 154 | 2729.1 | 2,358 | 994 | 1,087 | 219 | 837 | 40 | 204 | 61 | 11,191 | 128 | 8.02 | 2.76 | 2.90 | 0.72 | 21.7 | 7.5 | 1.17 | .279 | 3.58 | 7.78 |
| 12 | | K. Brown | 2,359 | 476 | 207 | 140 | .597 | 466 | 3.22 | 72 | 17 | 0 | 3202.0 | 3,000 | 1,146 | 1,314 | 205 | 886 | 132 | 1 | 41 | 13,282 | 103 | 6.63 | 2.49 | 2.66 | 0.58 | 17.8 | 6.7 | 1.21 | .288 | 3.69 | 8.43 |
| 13 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 14 | | M. Mussina | 2,276 | 418 | 212 | 121 | .637 | 418 | 3.61 | 54 | 21 | 0 | 2862.1 | 2,718 | 1,147 | 1,222 | 303 | 647 | 39 | 0 | 23 | 11,683 | 62 | 7.16 | 2.03 | 3.52 | 0.95 | 19.5 | 5.5 | 1.18 | .287 | 3.84 | 8.55 |
| 15 | | T. Glavine | 2,262 | 575 | 263 | 174 | .602 | 575 | 3.45 | 53 | 23 | 0 | 3767.1 | 3,616 | 1,446 | 1,594 | 291 | 1,292 | 52 | 0 | 127 | 15,852 | 61 | 5.40 | 3.09 | 1.75 | 0.70 | 14.3 | 8.2 | 1.30 | .278 | 3.81 | 8.64 |
| 16 | | B. Blyleven | 2,155 | 440 | 179 | 149 | .546 | 436 | 3.64 | 127 | 30 | 0 | 3061.0 | 2,933 | 1,237 | 1,357 | 302 | 838 | 104 | 1 | 42 | 12,733 | 76 | 6.34 | 2.46 | 2.57 | 0.89 | 16.9 | 6.6 | 1.23 | .282 | 3.99 | 8.62 |
| 17 | | D. Martinez | 2,131 | 688 | 244 | 191 | .561 | 560 | 3.70 | 121 | 30 | 8 | 3972.0 | 3,874 | 1,635 | 1,827 | 371 | 1,157 | 122 | 50 | 70 | 16,648 | 83 | 4.83 | 2.62 | 1.84 | 0.84 | 12.8 | 6.9 | 1.27 | .272 | 4.14 | 8.78 |
| 18 | | C. Hough | 2,098 | 643 | 188 | 195 | .491 | 440 | 3.84 | 107 | 13 | 31 | 3406.0 | 2,998 | 1,452 | 1,655 | 351 | 1,453 | 147 | 117 | 37 | 14,495 | 160 | 5.54 | 3.84 | 1.44 | 0.93 | 14.5 | 10.0 | 1.31 | .253 | 4.37 | 7.92 |
| 19 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 20 | | D. Eckersley | 2,049 | 1,001 | 171 | 152 | .529 | 307 | 3.57 | 85 | 15 | 387 | 2899.2 | 2,774 | 1,149 | 1,239 | 318 | 570 | 63 | 569 | 80 | 11,919 | 18 | 6.36 | 1.77 | 3.59 | 0.99 | 17.2 | 4.8 | 1.15 | .275 | 3.85 | 8.61 |
| 21 | | F. Tanana | 2,041 | 527 | 189 | 196 | .491 | 510 | 3.89 | 90 | 22 | 1 | 3347.2 | 3,358 | 1,447 | 1,627 | 374 | 1,024 | 105 | 7 | 101 | 14,235 | 100 | 5.49 | 2.75 | 1.99 | 1.01 | 14.3 | 7.2 | 1.31 | .279 | 4.37 | 9.03 |
| 22 |  | S. Carlton | 2,025 | 359 | 161 | 118 | .577 | 345 | 3.34 | 96 | 22 | 1 | 2513.2 | 2,263 | 932 | 1,076 | 215 | 872 | 24 | 6 | 73 | 10,441 | 92 | 7.25 | 3.12 | 2.32 | 0.77 | 19.4 | 8.4 | 1.25 | .280 | 3.85 | 8.10 |
| 23 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 24 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 25 | | K. Appier | 1,994 | 414 | 169 | 137 | .552 | 402 | 3.74 | 34 | 12 | 0 | 2595.1 | 2,425 | 1,078 | 1,168 | 232 | 933 | 79 | 2 | 51 | 10,958 | 106 | 6.91 | 3.24 | 2.14 | 0.80 | 18.2 | 8.5 | 1.29 | .284 | 4.05 | 8.41 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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