Between January 1, 1982 and April 13, 2007, Roger Clemens struck out the most hitters, with 4,604 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 4,604 | 691 | 348 | 178 | .662 | 690 | 3.10 | 118 | 46 | 0 | 4817.2 | 4,086 | 1,661 | 1,833 | 354 | 1,549 | 154 | 0 | 63 | 19,820 | 136 | 8.60 | 2.89 | 2.97 | 0.66 | 23.2 | 7.8 | 1.17 | .284 | 3.42 | 7.63 |
| 2 |  | R. Johnson | 4,544 | 556 | 280 | 147 | .656 | 546 | 3.22 | 98 | 37 | 2 | 3798.2 | 3,013 | 1,357 | 1,530 | 361 | 1,409 | 178 | 5 | 26 | 15,644 | 101 | 10.77 | 3.34 | 3.22 | 0.86 | 29.0 | 9.0 | 1.16 | .290 | 3.62 | 7.14 |
| 3 |  | G. Maddux | 3,179 | 679 | 334 | 204 | .621 | 675 | 3.07 | 108 | 35 | 0 | 4627.2 | 4,312 | 1,578 | 1,788 | 319 | 945 | 126 | 3 | 169 | 18,833 | 64 | 6.18 | 1.84 | 3.36 | 0.62 | 16.9 | 5.0 | 1.14 | .280 | 3.48 | 8.39 |
| 4 |  | C. Schilling | 3,026 | 547 | 208 | 139 | .599 | 414 | 3.44 | 82 | 19 | 22 | 3121.0 | 2,845 | 1,194 | 1,256 | 327 | 691 | 50 | 81 | 42 | 12,698 | 72 | 8.73 | 1.99 | 4.38 | 0.94 | 23.8 | 5.4 | 1.13 | .293 | 3.62 | 8.20 |
| 5 |  | P. Martinez | 2,998 | 442 | 206 | 92 | .691 | 375 | 2.81 | 46 | 17 | 3 | 2645.2 | 2,013 | 825 | 907 | 213 | 701 | 129 | 23 | 26 | 10,582 | 59 | 10.20 | 2.38 | 4.28 | 0.72 | 28.3 | 6.6 | 1.03 | .275 | 3.09 | 6.85 |
| 6 |  | J. Smoltz | 2,795 | 673 | 194 | 138 | .584 | 432 | 3.27 | 53 | 16 | 154 | 3181.1 | 2,777 | 1,157 | 1,257 | 259 | 946 | 52 | 204 | 75 | 13,045 | 136 | 7.91 | 2.68 | 2.95 | 0.73 | 21.4 | 7.3 | 1.17 | .280 | 3.56 | 7.86 |
| 7 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 8 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 9 | | M. Mussina | 2,576 | 477 | 239 | 135 | .639 | 477 | 3.64 | 57 | 23 | 0 | 3216.1 | 3,069 | 1,302 | 1,390 | 345 | 723 | 49 | 0 | 24 | 13,151 | 66 | 7.21 | 2.02 | 3.56 | 0.97 | 19.6 | 5.5 | 1.18 | .288 | 3.89 | 8.59 |
| 10 | | T. Glavine | 2,489 | 638 | 292 | 192 | .603 | 638 | 3.46 | 55 | 24 | 0 | 4167.0 | 4,026 | 1,602 | 1,767 | 325 | 1,406 | 63 | 0 | 139 | 17,540 | 63 | 5.38 | 3.04 | 1.77 | 0.70 | 14.2 | 8.0 | 1.30 | .279 | 3.82 | 8.70 |
| 11 |  | N. Ryan | 2,465 | 355 | 135 | 118 | .534 | 355 | 3.31 | 44 | 14 | 0 | 2312.0 | 1,730 | 850 | 967 | 160 | 983 | 74 | 0 | 34 | 9,584 | 126 | 9.60 | 3.83 | 2.51 | 0.62 | 25.7 | 10.3 | 1.17 | .266 | 3.76 | 6.73 |
| 12 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 13 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 14 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 15 | | D. Wells | 2,124 | 633 | 230 | 149 | .607 | 462 | 4.08 | 54 | 12 | 13 | 3290.2 | 3,448 | 1,490 | 1,612 | 386 | 678 | 80 | 65 | 60 | 13,758 | 100 | 5.81 | 1.85 | 3.13 | 1.06 | 15.4 | 4.9 | 1.25 | .292 | 4.41 | 9.43 |
| 16 |  | J. Morris | 2,080 | 426 | 203 | 151 | .573 | 426 | 3.96 | 139 | 24 | 0 | 3026.2 | 2,838 | 1,332 | 1,468 | 324 | 1,094 | 45 | 0 | 74 | 12,784 | 182 | 6.19 | 3.25 | 1.90 | 0.96 | 16.3 | 8.6 | 1.30 | .272 | 4.37 | 8.44 |
| 17 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 18 | | J. Moyer | 2,001 | 573 | 217 | 167 | .565 | 520 | 4.16 | 30 | 9 | 0 | 3363.2 | 3,469 | 1,556 | 1,684 | 415 | 950 | 115 | 14 | 60 | 14,292 | 51 | 5.35 | 2.54 | 2.11 | 1.11 | 14.0 | 6.6 | 1.31 | .282 | 4.51 | 9.28 |
| 19 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 20 | | K. Appier | 1,994 | 414 | 169 | 137 | .552 | 402 | 3.74 | 34 | 12 | 0 | 2595.1 | 2,425 | 1,078 | 1,168 | 232 | 933 | 79 | 2 | 51 | 10,958 | 106 | 6.91 | 3.24 | 2.14 | 0.80 | 18.2 | 8.5 | 1.29 | .284 | 4.05 | 8.41 |
| 21 | | A. Leiter | 1,974 | 419 | 162 | 132 | .551 | 382 | 3.80 | 16 | 10 | 2 | 2391.0 | 2,152 | 1,010 | 1,101 | 198 | 1,163 | 117 | 9 | 53 | 10,334 | 63 | 7.43 | 4.38 | 1.70 | 0.75 | 19.1 | 11.3 | 1.39 | .284 | 4.14 | 8.10 |
| 22 | | B. Witt | 1,955 | 430 | 142 | 157 | .475 | 397 | 4.83 | 47 | 11 | 0 | 2465.0 | 2,493 | 1,324 | 1,449 | 252 | 1,375 | 39 | 13 | 37 | 11,003 | 128 | 7.14 | 5.02 | 1.42 | 0.92 | 17.8 | 12.5 | 1.57 | .304 | 5.29 | 9.10 |
| 23 | | H. Nomo | 1,915 | 320 | 123 | 109 | .530 | 318 | 4.21 | 16 | 9 | 0 | 1972.0 | 1,758 | 923 | 984 | 248 | 904 | 38 | 0 | 31 | 8,435 | 109 | 8.74 | 4.13 | 2.12 | 1.13 | 22.7 | 10.7 | 1.35 | .283 | 4.49 | 8.02 |
| 24 | | F. Valenzuela | 1,878 | 418 | 158 | 146 | .520 | 399 | 3.64 | 102 | 23 | 1 | 2720.0 | 2,570 | 1,101 | 1,246 | 215 | 1,085 | 24 | 6 | 61 | 11,574 | 115 | 6.21 | 3.59 | 1.73 | 0.71 | 16.2 | 9.4 | 1.34 | .281 | 4.12 | 8.50 |
| 25 | | T. Gordon | 1,874 | 812 | 130 | 119 | .522 | 203 | 3.91 | 18 | 4 | 151 | 2039.2 | 1,821 | 887 | 974 | 167 | 944 | 36 | 329 | 56 | 8,754 | 105 | 8.27 | 4.17 | 1.99 | 0.74 | 21.4 | 10.8 | 1.36 | .289 | 4.30 | 8.04 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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