Between July 15, 1963 and September 7, 2004, Nolan Ryan fanned the most hitters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | R. Clemens | 4,276 | 635 | 325 | 164 | .665 | 634 | 3.19 | 117 | 46 | 0 | 4457.2 | 3,825 | 1,582 | 1,742 | 335 | 1,448 | 146 | 0 | 57 | 18,397 | 130 | 8.63 | 2.92 | 2.95 | 0.68 | 23.2 | 7.9 | 1.18 | .286 | 3.52 | 7.72 |
| 3 |  | S. Carlton | 4,136 | 741 | 329 | 244 | .574 | 709 | 3.22 | 254 | 55 | 2 | 5217.2 | 4,672 | 1,864 | 2,130 | 414 | 1,833 | 53 | 13 | 150 | 21,682 | 183 | 7.13 | 3.16 | 2.26 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.67 | 8.06 |
| 4 |  | R. Johnson | 4,120 | 484 | 242 | 127 | .656 | 474 | 3.09 | 92 | 37 | 2 | 3331.0 | 2,580 | 1,142 | 1,290 | 299 | 1,298 | 155 | 5 | 23 | 13,716 | 95 | 11.13 | 3.51 | 3.17 | 0.81 | 30.0 | 9.5 | 1.16 | .291 | 3.49 | 6.97 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 8 | | G. Perry | 3,480 | 744 | 310 | 261 | .543 | 682 | 3.09 | 302 | 53 | 8 | 5261.1 | 4,837 | 1,804 | 2,078 | 391 | 1,348 | 106 | 27 | 157 | 21,556 | 156 | 5.95 | 2.31 | 2.58 | 0.67 | 16.1 | 6.3 | 1.18 | .274 | 3.55 | 8.27 |
| 9 | | P. Niekro | 3,342 | 864 | 318 | 274 | .537 | 716 | 3.35 | 245 | 45 | 29 | 5404.0 | 5,044 | 2,012 | 2,337 | 482 | 1,809 | 123 | 83 | 86 | 22,677 | 227 | 5.57 | 3.01 | 1.85 | 0.80 | 14.7 | 8.0 | 1.27 | .270 | 3.89 | 8.40 |
| 10 | | F. Jenkins | 3,191 | 664 | 284 | 226 | .557 | 594 | 3.34 | 267 | 49 | 7 | 4500.2 | 4,142 | 1,669 | 1,853 | 484 | 997 | 84 | 37 | 117 | 18,404 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.28 |
| 11 |  | G. Maddux | 2,885 | 602 | 302 | 171 | .638 | 598 | 2.93 | 105 | 35 | 0 | 4143.2 | 3,804 | 1,347 | 1,537 | 260 | 866 | 116 | 3 | 157 | 16,832 | 55 | 6.27 | 1.88 | 3.33 | 0.56 | 17.1 | 5.1 | 1.13 | .279 | 3.34 | 8.26 |
| 12 | | M. Lolich | 2,780 | 571 | 213 | 187 | .533 | 488 | 3.44 | 192 | 41 | 10 | 3566.0 | 3,291 | 1,362 | 1,505 | 340 | 1,076 | 88 | 39 | 66 | 14,831 | 116 | 7.02 | 2.72 | 2.58 | 0.86 | 18.7 | 7.3 | 1.22 | .280 | 3.80 | 8.31 |
| 13 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 14 | | C. Schilling | 2,714 | 478 | 181 | 123 | .595 | 366 | 3.33 | 82 | 19 | 13 | 2783.0 | 2,476 | 1,031 | 1,093 | 284 | 631 | 44 | 60 | 41 | 11,287 | 70 | 8.78 | 2.04 | 4.30 | 0.92 | 24.0 | 5.6 | 1.12 | .288 | 3.53 | 8.01 |
| 15 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 16 |  | P. Martinez | 2,623 | 383 | 181 | 72 | .715 | 316 | 2.66 | 42 | 16 | 3 | 2266.2 | 1,714 | 671 | 745 | 169 | 601 | 112 | 23 | 21 | 9,051 | 53 | 10.41 | 2.39 | 4.36 | 0.67 | 29.0 | 6.6 | 1.02 | .279 | 2.96 | 6.81 |
| 17 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 18 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 19 |  | B. Gibson | 2,537 | 402 | 208 | 134 | .608 | 388 | 2.78 | 222 | 47 | 4 | 3158.1 | 2,631 | 974 | 1,088 | 209 | 983 | 74 | 8 | 94 | 12,922 | 82 | 7.23 | 2.80 | 2.58 | 0.60 | 19.6 | 7.6 | 1.14 | .266 | 3.10 | 7.50 |
| 20 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 21 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 22 | | L. Tiant | 2,416 | 573 | 229 | 172 | .571 | 484 | 3.30 | 187 | 49 | 15 | 3486.1 | 3,075 | 1,280 | 1,400 | 346 | 1,104 | 49 | 51 | 53 | 14,366 | 27 | 6.24 | 2.85 | 2.19 | 0.89 | 16.8 | 7.7 | 1.20 | .261 | 3.61 | 7.94 |
| 23 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 24 |  | J. Smoltz | 2,389 | 591 | 163 | 120 | .576 | 361 | 3.26 | 47 | 14 | 146 | 2688.1 | 2,310 | 973 | 1,065 | 215 | 823 | 40 | 195 | 60 | 11,014 | 126 | 8.00 | 2.76 | 2.90 | 0.72 | 21.7 | 7.5 | 1.17 | .278 | 3.57 | 7.73 |
| 25 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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