Between June 17, 1965 and June 5, 2005, Nolan Ryan struck out the most hitters, with 5,714 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | R. Clemens | 4,397 | 652 | 332 | 167 | .665 | 651 | 3.15 | 117 | 46 | 0 | 4574.0 | 3,900 | 1,603 | 1,764 | 339 | 1,479 | 148 | 0 | 59 | 18,849 | 130 | 8.65 | 2.91 | 2.97 | 0.67 | 23.3 | 7.8 | 1.18 | .285 | 3.47 | 7.67 |
| 3 |  | R. Johnson | 4,226 | 500 | 251 | 132 | .655 | 490 | 3.09 | 94 | 37 | 2 | 3446.0 | 2,690 | 1,182 | 1,340 | 311 | 1,319 | 161 | 5 | 24 | 14,191 | 96 | 11.04 | 3.44 | 3.20 | 0.81 | 29.8 | 9.3 | 1.16 | .291 | 3.50 | 7.03 |
| 4 |  | S. Carlton | 4,124 | 731 | 329 | 244 | .574 | 708 | 3.22 | 254 | 55 | 2 | 5201.0 | 4,652 | 1,858 | 2,124 | 411 | 1,829 | 52 | 11 | 149 | 21,611 | 180 | 7.14 | 3.16 | 2.25 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 8 | | P. Niekro | 3,320 | 840 | 317 | 274 | .536 | 716 | 3.35 | 245 | 45 | 27 | 5363.2 | 5,011 | 1,998 | 2,315 | 480 | 1,794 | 120 | 72 | 85 | 22,504 | 222 | 5.57 | 3.01 | 1.85 | 0.81 | 14.8 | 8.0 | 1.27 | .270 | 3.88 | 8.41 |
| 9 | | G. Perry | 3,214 | 674 | 292 | 242 | .547 | 646 | 3.08 | 292 | 51 | 4 | 4920.0 | 4,531 | 1,685 | 1,952 | 358 | 1,266 | 99 | 15 | 142 | 20,154 | 142 | 5.88 | 2.32 | 2.54 | 0.65 | 15.9 | 6.3 | 1.18 | .274 | 3.57 | 8.29 |
| 10 | | F. Jenkins | 3,191 | 664 | 284 | 226 | .557 | 594 | 3.34 | 267 | 49 | 7 | 4500.2 | 4,142 | 1,669 | 1,853 | 484 | 997 | 84 | 37 | 117 | 18,404 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.28 |
| 11 |  | G. Maddux | 2,961 | 620 | 309 | 177 | .636 | 616 | 2.97 | 105 | 35 | 0 | 4255.2 | 3,922 | 1,404 | 1,600 | 279 | 883 | 120 | 3 | 159 | 17,298 | 59 | 6.26 | 1.87 | 3.35 | 0.59 | 17.1 | 5.1 | 1.13 | .279 | 3.38 | 8.29 |
| 12 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 13 | | C. Schilling | 2,765 | 485 | 185 | 125 | .597 | 373 | 3.35 | 82 | 19 | 13 | 2830.1 | 2,521 | 1,055 | 1,117 | 289 | 641 | 46 | 60 | 41 | 11,484 | 70 | 8.79 | 2.04 | 4.31 | 0.92 | 24.1 | 5.6 | 1.12 | .288 | 3.55 | 8.02 |
| 14 |  | P. Martinez | 2,745 | 399 | 188 | 77 | .709 | 332 | 2.71 | 43 | 16 | 3 | 2375.0 | 1,790 | 714 | 790 | 181 | 627 | 116 | 23 | 21 | 9,480 | 57 | 10.40 | 2.38 | 4.38 | 0.69 | 29.0 | 6.6 | 1.02 | .277 | 2.99 | 6.78 |
| 15 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 16 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 17 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 18 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 19 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 20 | | M. Lolich | 2,464 | 494 | 187 | 171 | .522 | 433 | 3.46 | 177 | 34 | 6 | 3170.0 | 2,948 | 1,218 | 1,351 | 296 | 951 | 78 | 27 | 64 | 13,199 | 105 | 7.00 | 2.70 | 2.59 | 0.84 | 18.7 | 7.2 | 1.23 | .282 | 3.84 | 8.37 |
| 21 |  | J. Smoltz | 2,456 | 614 | 167 | 125 | .572 | 373 | 3.27 | 47 | 14 | 154 | 2774.2 | 2,404 | 1,008 | 1,104 | 220 | 856 | 40 | 204 | 64 | 11,388 | 129 | 7.97 | 2.78 | 2.87 | 0.71 | 21.6 | 7.5 | 1.17 | .279 | 3.58 | 7.80 |
| 22 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 23 | | K. Brown | 2,386 | 483 | 211 | 143 | .596 | 473 | 3.24 | 72 | 17 | 0 | 3244.1 | 3,056 | 1,169 | 1,341 | 205 | 896 | 138 | 1 | 42 | 13,479 | 107 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.6 | 1.22 | .289 | 3.72 | 8.48 |
| 24 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 25 | | M. Mussina | 2,305 | 425 | 216 | 123 | .637 | 425 | 3.61 | 55 | 22 | 0 | 2906.1 | 2,761 | 1,166 | 1,241 | 309 | 656 | 39 | 0 | 23 | 11,862 | 62 | 7.14 | 2.03 | 3.51 | 0.96 | 19.4 | 5.5 | 1.18 | .287 | 3.84 | 8.55 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
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| NL Central | W | L | PCT | GB |
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