Between May 17, 1957 and May 20, 2002, Nolan Ryan struck out the most hitters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | S. Carlton | 4,136 | 741 | 329 | 244 | .574 | 709 | 3.22 | 254 | 55 | 2 | 5217.2 | 4,672 | 1,864 | 2,130 | 414 | 1,833 | 53 | 13 | 150 | 21,682 | 183 | 7.13 | 3.16 | 2.26 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.67 | 8.06 |
| 3 |  | R. Clemens | 3,789 | 555 | 287 | 147 | .661 | 554 | 3.10 | 116 | 45 | 0 | 3954.2 | 3,358 | 1,363 | 1,506 | 282 | 1,284 | 131 | 0 | 46 | 16,286 | 108 | 8.62 | 2.92 | 2.95 | 0.64 | 23.3 | 7.9 | 1.17 | .285 | 3.43 | 7.64 |
| 4 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 5 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 6 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 7 | | G. Perry | 3,534 | 777 | 314 | 265 | .542 | 690 | 3.11 | 303 | 53 | 10 | 5350.0 | 4,938 | 1,846 | 2,128 | 399 | 1,378 | 108 | 33 | 163 | 21,953 | 160 | 5.95 | 2.32 | 2.56 | 0.67 | 16.1 | 6.3 | 1.18 | .275 | 3.58 | 8.31 |
| 8 |  | R. Johnson | 3,497 | 410 | 207 | 102 | .670 | 400 | 3.10 | 81 | 31 | 2 | 2815.1 | 2,162 | 970 | 1,092 | 247 | 1,177 | 126 | 5 | 18 | 11,636 | 88 | 11.18 | 3.76 | 2.97 | 0.79 | 30.1 | 10.1 | 1.19 | .291 | 3.49 | 6.91 |
| 9 | | P. Niekro | 3,342 | 864 | 318 | 274 | .537 | 716 | 3.35 | 245 | 45 | 29 | 5404.0 | 5,044 | 2,012 | 2,337 | 482 | 1,809 | 123 | 83 | 86 | 22,677 | 227 | 5.57 | 3.01 | 1.85 | 0.80 | 14.7 | 8.0 | 1.27 | .270 | 3.89 | 8.40 |
| 10 | | F. Jenkins | 3,191 | 664 | 284 | 226 | .557 | 594 | 3.34 | 267 | 49 | 7 | 4500.2 | 4,142 | 1,669 | 1,853 | 484 | 997 | 84 | 37 | 117 | 18,404 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.28 |
| 11 |  | B. Gibson | 3,117 | 528 | 251 | 174 | .591 | 482 | 2.91 | 255 | 56 | 6 | 3884.1 | 3,279 | 1,258 | 1,420 | 257 | 1,336 | 102 | 21 | 118 | 16,066 | 109 | 7.22 | 3.10 | 2.33 | 0.60 | 19.4 | 8.3 | 1.19 | .269 | 3.29 | 7.60 |
| 12 | | M. Lolich | 2,832 | 586 | 217 | 191 | .532 | 496 | 3.44 | 195 | 41 | 10 | 3638.1 | 3,366 | 1,390 | 1,537 | 347 | 1,099 | 91 | 40 | 67 | 15,139 | 123 | 7.01 | 2.72 | 2.58 | 0.86 | 18.7 | 7.3 | 1.23 | .280 | 3.80 | 8.33 |
| 13 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 14 | | J. Bunning | 2,754 | 548 | 214 | 177 | .547 | 506 | 3.23 | 150 | 40 | 13 | 3623.0 | 3,297 | 1,301 | 1,456 | 358 | 925 | 157 | 29 | 91 | 15,002 | 42 | 6.84 | 2.30 | 2.98 | 0.89 | 18.4 | 6.2 | 1.17 | .272 | 3.62 | 8.19 |
| 15 | | D. Cone | 2,655 | 445 | 193 | 123 | .611 | 415 | 3.45 | 56 | 22 | 1 | 2880.2 | 2,484 | 1,103 | 1,209 | 254 | 1,124 | 106 | 9 | 41 | 12,099 | 149 | 8.29 | 3.51 | 2.36 | 0.79 | 21.9 | 9.3 | 1.25 | .280 | 3.78 | 7.76 |
| 16 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 17 |  | G. Maddux | 2,549 | 513 | 261 | 148 | .638 | 509 | 2.84 | 102 | 34 | 0 | 3594.2 | 3,246 | 1,135 | 1,300 | 199 | 776 | 98 | 3 | 144 | 14,576 | 49 | 6.38 | 1.94 | 3.28 | 0.50 | 17.5 | 5.3 | 1.12 | .278 | 3.25 | 8.13 |
| 18 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 19 | | C. Finley | 2,472 | 500 | 191 | 163 | .540 | 443 | 3.84 | 61 | 14 | 0 | 3050.0 | 2,942 | 1,303 | 1,447 | 296 | 1,277 | 75 | 24 | 30 | 13,028 | 128 | 7.29 | 3.77 | 1.94 | 0.87 | 19.0 | 9.8 | 1.38 | .297 | 4.27 | 8.68 |
| 20 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 21 | | J. Kaat | 2,462 | 898 | 283 | 237 | .544 | 625 | 3.45 | 180 | 31 | 17 | 4530.0 | 4,620 | 1,738 | 2,038 | 395 | 1,083 | 122 | 102 | 117 | 19,026 | 128 | 4.89 | 2.15 | 2.27 | 0.78 | 12.9 | 5.7 | 1.26 | .282 | 4.05 | 9.18 |
| 22 | | S. McDowell | 2,453 | 425 | 141 | 134 | .513 | 346 | 3.17 | 103 | 23 | 14 | 2492.1 | 1,948 | 879 | 999 | 164 | 1,312 | 59 | 39 | 73 | 10,589 | 141 | 8.86 | 4.74 | 1.87 | 0.59 | 23.2 | 12.4 | 1.31 | .270 | 3.61 | 7.03 |
| 23 | | L. Tiant | 2,416 | 573 | 229 | 172 | .571 | 484 | 3.30 | 187 | 49 | 15 | 3486.1 | 3,075 | 1,280 | 1,400 | 346 | 1,104 | 49 | 51 | 53 | 14,366 | 27 | 6.24 | 2.85 | 2.19 | 0.89 | 16.8 | 7.7 | 1.20 | .261 | 3.61 | 7.94 |
| 24 | | D. Drysdale | 2,407 | 489 | 202 | 161 | .556 | 449 | 2.96 | 164 | 49 | 6 | 3302.2 | 2,963 | 1,086 | 1,247 | 268 | 816 | 149 | 28 | 120 | 13,557 | 78 | 6.56 | 2.22 | 2.95 | 0.73 | 17.8 | 6.0 | 1.14 | .272 | 3.40 | 8.07 |
| 25 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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