Between May 18, 1981 and May 21, 2013, Randy Johnson struck out the most hitters, with 4,875 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 2 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 3 |  | G. Maddux | 3,371 | 744 | 355 | 227 | .610 | 740 | 3.16 | 109 | 35 | 0 | 5008.1 | 4,726 | 1,756 | 1,981 | 353 | 999 | 137 | 3 | 177 | 20,421 | 70 | 6.06 | 1.80 | 3.37 | 0.63 | 16.5 | 4.9 | 1.14 | .281 | 3.56 | 8.49 |
| 4 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 5 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 6 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 9 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 10 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 11 |  | N. Ryan | 2,563 | 370 | 143 | 122 | .540 | 370 | 3.25 | 48 | 16 | 0 | 2419.0 | 1,796 | 873 | 994 | 162 | 1,034 | 74 | 0 | 35 | 10,014 | 137 | 9.54 | 3.85 | 2.48 | 0.60 | 25.6 | 10.3 | 1.17 | .264 | 3.70 | 6.68 |
| 12 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 13 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 14 | | J. Moyer | 2,441 | 696 | 269 | 209 | .563 | 638 | 4.25 | 33 | 10 | 0 | 4074.0 | 4,231 | 1,926 | 2,076 | 522 | 1,155 | 146 | 15 | 69 | 17,356 | 57 | 5.39 | 2.55 | 2.11 | 1.15 | 14.1 | 6.7 | 1.32 | .283 | 4.59 | 9.35 |
| 15 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 16 | | A. Pettitte | 2,359 | 509 | 249 | 145 | .632 | 499 | 3.85 | 25 | 4 | 0 | 3180.0 | 3,299 | 1,362 | 1,510 | 277 | 998 | 54 | 3 | 41 | 13,498 | 65 | 6.68 | 2.82 | 2.36 | 0.78 | 17.5 | 7.4 | 1.35 | .308 | 4.27 | 9.34 |
| 17 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 18 |  | CC Sabathia | 2,270 | 393 | 195 | 105 | .650 | 393 | 3.50 | 35 | 12 | 0 | 2630.0 | 2,433 | 1,023 | 1,123 | 236 | 784 | 82 | 0 | 35 | 10,902 | 51 | 7.77 | 2.68 | 2.90 | 0.81 | 20.8 | 7.2 | 1.22 | .292 | 3.84 | 8.33 |
| 19 | | D. Wells | 2,201 | 660 | 239 | 157 | .604 | 489 | 4.13 | 54 | 12 | 13 | 3439.0 | 3,635 | 1,578 | 1,702 | 407 | 719 | 83 | 65 | 65 | 14,413 | 101 | 5.76 | 1.88 | 3.06 | 1.07 | 15.3 | 5.0 | 1.27 | .293 | 4.45 | 9.51 |
| 20 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 21 |  | J. Morris | 2,145 | 443 | 213 | 155 | .579 | 443 | 3.92 | 149 | 25 | 0 | 3157.1 | 2,931 | 1,376 | 1,513 | 334 | 1,144 | 46 | 0 | 83 | 13,306 | 183 | 6.11 | 3.26 | 1.88 | 0.95 | 16.1 | 8.6 | 1.29 | .269 | 4.31 | 8.35 |
| 22 | | R. Halladay | 2,101 | 410 | 201 | 104 | .659 | 384 | 3.37 | 67 | 20 | 1 | 2721.2 | 2,624 | 1,020 | 1,120 | 233 | 573 | 75 | 6 | 27 | 11,160 | 54 | 6.95 | 1.89 | 3.67 | 0.77 | 18.8 | 5.1 | 1.17 | .292 | 3.70 | 8.68 |
| 23 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 24 | | A.J. Burnett | 2,050 | 355 | 140 | 125 | .528 | 350 | 4.01 | 22 | 10 | 0 | 2225.2 | 2,021 | 991 | 1,082 | 224 | 911 | 111 | 1 | 29 | 9,486 | 139 | 8.29 | 3.68 | 2.25 | 0.91 | 21.6 | 9.6 | 1.32 | .290 | 4.38 | 8.17 |
| 25 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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