Between May 22, 1966 and August 27, 2005, Nolan Ryan struck out the most batters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | R. Clemens | 4,479 | 666 | 339 | 170 | .666 | 665 | 3.12 | 118 | 46 | 0 | 4671.1 | 3,964 | 1,619 | 1,784 | 344 | 1,505 | 149 | 0 | 59 | 19,222 | 131 | 8.63 | 2.90 | 2.98 | 0.66 | 23.3 | 7.8 | 1.17 | .284 | 3.44 | 7.64 |
| 3 |  | R. Johnson | 4,334 | 516 | 258 | 136 | .655 | 506 | 3.13 | 96 | 37 | 2 | 3550.1 | 2,794 | 1,233 | 1,395 | 330 | 1,336 | 166 | 5 | 25 | 14,616 | 98 | 10.99 | 3.39 | 3.24 | 0.84 | 29.7 | 9.1 | 1.16 | .292 | 3.54 | 7.08 |
| 4 |  | S. Carlton | 4,115 | 726 | 329 | 244 | .574 | 707 | 3.22 | 254 | 55 | 2 | 5192.2 | 4,645 | 1,857 | 2,123 | 411 | 1,825 | 52 | 8 | 149 | 21,578 | 178 | 7.13 | 3.16 | 2.25 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,524 | 765 | 319 | 252 | .559 | 747 | 3.26 | 176 | 57 | 5 | 5221.0 | 4,636 | 1,894 | 2,083 | 468 | 1,334 | 80 | 12 | 102 | 21,382 | 111 | 6.07 | 2.30 | 2.64 | 0.81 | 16.5 | 6.2 | 1.14 | .261 | 3.59 | 7.99 |
| 8 | | P. Niekro | 3,278 | 801 | 314 | 268 | .540 | 715 | 3.35 | 245 | 45 | 23 | 5295.0 | 4,937 | 1,972 | 2,280 | 474 | 1,765 | 117 | 56 | 79 | 22,195 | 215 | 5.57 | 3.00 | 1.86 | 0.81 | 14.8 | 8.0 | 1.27 | .269 | 3.88 | 8.39 |
| 9 | | F. Jenkins | 3,152 | 646 | 281 | 225 | .555 | 593 | 3.34 | 267 | 49 | 5 | 4455.0 | 4,110 | 1,652 | 1,835 | 477 | 986 | 83 | 26 | 115 | 18,219 | 62 | 6.37 | 1.99 | 3.20 | 0.96 | 17.3 | 5.4 | 1.14 | .269 | 3.71 | 8.30 |
| 10 | | G. Perry | 3,096 | 634 | 285 | 234 | .549 | 627 | 3.04 | 288 | 50 | 3 | 4779.1 | 4,379 | 1,615 | 1,868 | 349 | 1,214 | 94 | 7 | 132 | 19,536 | 136 | 5.83 | 2.29 | 2.55 | 0.66 | 15.8 | 6.2 | 1.17 | .273 | 3.52 | 8.25 |
| 11 |  | G. Maddux | 3,022 | 636 | 315 | 185 | .630 | 632 | 3.01 | 107 | 35 | 0 | 4360.0 | 4,033 | 1,458 | 1,655 | 293 | 901 | 125 | 3 | 161 | 17,734 | 62 | 6.24 | 1.86 | 3.35 | 0.60 | 17.0 | 5.1 | 1.13 | .279 | 3.42 | 8.33 |
| 12 |  | P. Martinez | 2,835 | 414 | 195 | 81 | .707 | 347 | 2.71 | 45 | 16 | 3 | 2478.0 | 1,872 | 747 | 823 | 190 | 651 | 118 | 23 | 22 | 9,890 | 57 | 10.30 | 2.36 | 4.35 | 0.69 | 28.7 | 6.6 | 1.02 | .276 | 2.99 | 6.80 |
| 13 | | C. Schilling | 2,797 | 507 | 189 | 129 | .594 | 374 | 3.38 | 82 | 19 | 22 | 2859.2 | 2,555 | 1,075 | 1,137 | 294 | 648 | 47 | 81 | 41 | 11,612 | 70 | 8.80 | 2.04 | 4.32 | 0.93 | 24.1 | 5.6 | 1.12 | .289 | 3.58 | 8.04 |
| 14 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 15 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 16 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 17 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 18 |  | J. Smoltz | 2,547 | 630 | 176 | 127 | .581 | 389 | 3.25 | 50 | 15 | 154 | 2897.1 | 2,505 | 1,047 | 1,144 | 230 | 877 | 40 | 204 | 67 | 11,868 | 130 | 7.91 | 2.72 | 2.90 | 0.71 | 21.5 | 7.4 | 1.17 | .278 | 3.55 | 7.78 |
| 19 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 20 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 21 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 22 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 23 | | M. Mussina | 2,393 | 440 | 223 | 127 | .637 | 440 | 3.63 | 56 | 23 | 0 | 3002.1 | 2,857 | 1,210 | 1,286 | 322 | 679 | 42 | 0 | 23 | 12,259 | 63 | 7.17 | 2.04 | 3.52 | 0.97 | 19.5 | 5.5 | 1.18 | .287 | 3.86 | 8.56 |
| 24 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 25 | | T. Glavine | 2,316 | 597 | 272 | 182 | .599 | 597 | 3.46 | 53 | 23 | 0 | 3904.1 | 3,782 | 1,503 | 1,655 | 299 | 1,325 | 55 | 0 | 131 | 16,448 | 62 | 5.34 | 3.05 | 1.75 | 0.69 | 14.1 | 8.1 | 1.31 | .280 | 3.81 | 8.72 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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