Between October 2, 1987 and August 20, 2016, Randy Johnson struck out the most hitters, with 4,875 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 2 |  | R. Clemens | 3,990 | 605 | 295 | 162 | .646 | 604 | 3.13 | 83 | 37 | 0 | 4158.1 | 3,531 | 1,444 | 1,603 | 305 | 1,364 | 141 | 0 | 56 | 17,133 | 123 | 8.64 | 2.95 | 2.93 | 0.66 | 23.3 | 8.0 | 1.18 | .285 | 3.47 | 7.64 |
| 3 |  | G. Maddux | 3,252 | 709 | 347 | 210 | .623 | 709 | 3.07 | 107 | 34 | 0 | 4827.1 | 4,511 | 1,644 | 1,857 | 333 | 918 | 132 | 0 | 163 | 19,606 | 64 | 6.06 | 1.71 | 3.54 | 0.62 | 16.6 | 4.7 | 1.12 | .279 | 3.46 | 8.41 |
| 4 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 5 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 6 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | CC Sabathia | 2,684 | 474 | 221 | 139 | .614 | 474 | 3.72 | 38 | 12 | 0 | 3119.0 | 2,962 | 1,290 | 1,409 | 308 | 945 | 103 | 0 | 43 | 13,037 | 65 | 7.74 | 2.73 | 2.84 | 0.89 | 20.6 | 7.2 | 1.25 | .295 | 4.07 | 8.55 |
| 9 | | T. Glavine | 2,587 | 673 | 303 | 199 | .604 | 673 | 3.51 | 56 | 25 | 0 | 4363.0 | 4,243 | 1,703 | 1,866 | 351 | 1,467 | 63 | 0 | 141 | 18,366 | 64 | 5.34 | 3.03 | 1.76 | 0.72 | 14.1 | 8.0 | 1.31 | .280 | 3.85 | 8.75 |
| 10 | | D. Cone | 2,582 | 419 | 189 | 120 | .612 | 406 | 3.44 | 55 | 22 | 1 | 2779.2 | 2,389 | 1,061 | 1,162 | 245 | 1,080 | 100 | 2 | 40 | 11,666 | 144 | 8.36 | 3.50 | 2.39 | 0.79 | 22.1 | 9.3 | 1.25 | .280 | 3.76 | 7.74 |
| 11 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 12 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 13 | | C. Finley | 2,510 | 464 | 195 | 165 | .542 | 464 | 3.83 | 63 | 15 | 0 | 3060.1 | 2,927 | 1,302 | 1,446 | 295 | 1,266 | 72 | 0 | 32 | 13,035 | 124 | 7.38 | 3.72 | 1.98 | 0.87 | 19.3 | 9.7 | 1.37 | .296 | 4.25 | 8.61 |
| 14 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 15 | | K. Brown | 2,393 | 485 | 210 | 144 | .593 | 475 | 3.27 | 72 | 17 | 0 | 3251.1 | 3,073 | 1,183 | 1,355 | 208 | 901 | 139 | 1 | 42 | 13,523 | 108 | 6.62 | 2.49 | 2.66 | 0.58 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 16 |  | B. Colon | 2,334 | 501 | 229 | 161 | .587 | 492 | 3.94 | 36 | 13 | 0 | 3125.1 | 3,185 | 1,368 | 1,490 | 373 | 882 | 59 | 1 | 45 | 13,190 | 42 | 6.72 | 2.54 | 2.65 | 1.07 | 17.7 | 6.7 | 1.30 | .295 | 4.29 | 9.17 |
| 17 | | J. Moyer | 2,251 | 646 | 251 | 190 | .569 | 590 | 4.19 | 31 | 9 | 0 | 3790.2 | 3,923 | 1,763 | 1,900 | 484 | 1,017 | 138 | 14 | 60 | 16,086 | 43 | 5.34 | 2.41 | 2.21 | 1.15 | 14.0 | 6.3 | 1.30 | .282 | 4.51 | 9.31 |
| 18 |  | F. Hernandez | 2,238 | 351 | 151 | 105 | .590 | 351 | 3.12 | 25 | 11 | 0 | 2372.2 | 2,108 | 823 | 916 | 196 | 676 | 80 | 0 | 16 | 9,716 | 130 | 8.49 | 2.56 | 3.31 | 0.74 | 23.0 | 7.0 | 1.17 | .293 | 3.47 | 8.00 |
| 19 | | J. Peavy | 2,206 | 386 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2375.0 | 2,132 | 959 | 1,010 | 259 | 706 | 78 | 3 | 42 | 9,829 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.19 | .285 | 3.83 | 8.08 |
| 20 | | D. Wells | 2,175 | 643 | 235 | 154 | .604 | 487 | 4.12 | 54 | 12 | 12 | 3415.2 | 3,602 | 1,565 | 1,688 | 407 | 710 | 83 | 60 | 65 | 14,305 | 97 | 5.73 | 1.87 | 3.06 | 1.07 | 15.2 | 5.0 | 1.26 | .292 | 4.45 | 9.49 |
| 21 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 22 | | J. Lackey | 2,121 | 412 | 174 | 134 | .565 | 411 | 3.89 | 18 | 8 | 0 | 2639.2 | 2,673 | 1,140 | 1,243 | 279 | 752 | 121 | 0 | 29 | 11,178 | 113 | 7.23 | 2.56 | 2.82 | 0.95 | 19.0 | 6.7 | 1.30 | .303 | 4.24 | 9.11 |
| 23 |  | J. Verlander | 2,119 | 343 | 169 | 104 | .619 | 343 | 3.51 | 23 | 7 | 0 | 2278.2 | 2,032 | 889 | 968 | 209 | 686 | 79 | 0 | 22 | 9,434 | 73 | 8.37 | 2.71 | 3.09 | 0.83 | 22.5 | 7.3 | 1.19 | .287 | 3.82 | 8.03 |
| 24 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 25 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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