Between September 10, 1972 and June 24, 2000, Nolan Ryan fanned the most batters, with 4,961 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 4,961 | 669 | 279 | 241 | .537 | 666 | 3.18 | 194 | 50 | 1 | 4645.0 | 3,415 | 1,643 | 1,880 | 274 | 2,319 | 125 | 3 | 61 | 19,405 | 241 | 9.61 | 4.49 | 2.14 | 0.53 | 25.6 | 12.0 | 1.23 | .268 | 3.64 | 6.62 |
| 2 |  | R. Clemens | 3,397 | 494 | 251 | 140 | .642 | 493 | 3.08 | 116 | 45 | 0 | 3543.2 | 3,001 | 1,211 | 1,344 | 247 | 1,139 | 118 | 0 | 44 | 14,577 | 92 | 8.63 | 2.89 | 2.98 | 0.63 | 23.3 | 7.8 | 1.17 | .285 | 3.41 | 7.62 |
| 3 |  | B. Blyleven | 3,163 | 594 | 249 | 210 | .542 | 590 | 3.37 | 213 | 52 | 0 | 4291.0 | 4,010 | 1,605 | 1,783 | 372 | 1,153 | 141 | 1 | 57 | 17,720 | 101 | 6.63 | 2.42 | 2.74 | 0.78 | 17.8 | 6.5 | 1.20 | .282 | 3.74 | 8.41 |
| 4 |  | S. Carlton | 2,913 | 516 | 229 | 174 | .568 | 502 | 3.35 | 164 | 31 | 1 | 3659.0 | 3,292 | 1,360 | 1,562 | 311 | 1,307 | 35 | 6 | 104 | 15,234 | 126 | 7.17 | 3.21 | 2.23 | 0.76 | 19.1 | 8.6 | 1.26 | .279 | 3.84 | 8.10 |
| 5 |  | R. Johnson | 2,857 | 347 | 171 | 90 | .655 | 338 | 3.17 | 73 | 27 | 2 | 2373.2 | 1,813 | 836 | 940 | 210 | 1,040 | 104 | 4 | 16 | 9,849 | 77 | 10.83 | 3.94 | 2.75 | 0.80 | 29.0 | 10.6 | 1.20 | .284 | 3.56 | 6.87 |
| 6 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 7 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 8 | | D. Cone | 2,475 | 404 | 181 | 108 | .626 | 375 | 3.28 | 56 | 22 | 1 | 2670.0 | 2,235 | 973 | 1,067 | 223 | 1,025 | 92 | 9 | 34 | 11,119 | 135 | 8.34 | 3.46 | 2.41 | 0.75 | 22.3 | 9.2 | 1.22 | .275 | 3.60 | 7.53 |
| 9 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 10 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 11 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 12 | | P. Niekro | 2,323 | 553 | 225 | 191 | .541 | 527 | 3.52 | 158 | 28 | 7 | 3775.1 | 3,590 | 1,475 | 1,688 | 339 | 1,416 | 88 | 17 | 54 | 16,007 | 139 | 5.54 | 3.38 | 1.64 | 0.81 | 14.5 | 8.8 | 1.33 | .275 | 4.02 | 8.56 |
| 13 |  | T. Seaver | 2,286 | 447 | 200 | 140 | .588 | 443 | 3.08 | 131 | 41 | 0 | 3184.1 | 2,692 | 1,089 | 1,197 | 265 | 974 | 44 | 1 | 86 | 12,994 | 90 | 6.46 | 2.75 | 2.35 | 0.75 | 17.6 | 7.5 | 1.15 | .258 | 3.38 | 7.61 |
| 14 |  | G. Maddux | 2,262 | 453 | 230 | 128 | .642 | 449 | 2.82 | 96 | 29 | 0 | 3192.1 | 2,875 | 999 | 1,149 | 167 | 716 | 85 | 3 | 124 | 12,963 | 46 | 6.38 | 2.02 | 3.16 | 0.47 | 17.4 | 5.5 | 1.12 | .278 | 3.24 | 8.11 |
| 15 | | D. Gooden | 2,262 | 412 | 190 | 110 | .633 | 405 | 3.51 | 68 | 24 | 1 | 2736.1 | 2,498 | 1,067 | 1,170 | 202 | 933 | 78 | 1 | 39 | 11,431 | 75 | 7.44 | 3.07 | 2.42 | 0.66 | 19.8 | 8.2 | 1.25 | .289 | 3.85 | 8.22 |
| 16 | | D. Sutton | 2,254 | 520 | 226 | 162 | .582 | 516 | 3.31 | 107 | 33 | 2 | 3569.2 | 3,184 | 1,311 | 1,446 | 344 | 908 | 49 | 3 | 54 | 14,627 | 70 | 5.68 | 2.29 | 2.48 | 0.87 | 15.4 | 6.2 | 1.15 | .257 | 3.65 | 8.03 |
| 17 | | C. Finley | 2,250 | 451 | 170 | 145 | .540 | 394 | 3.74 | 60 | 14 | 0 | 2778.1 | 2,632 | 1,154 | 1,285 | 264 | 1,171 | 72 | 24 | 28 | 11,836 | 124 | 7.29 | 3.79 | 1.92 | 0.86 | 19.0 | 9.9 | 1.37 | .293 | 4.16 | 8.53 |
| 18 | | D. Martinez | 2,149 | 692 | 245 | 193 | .559 | 562 | 3.70 | 122 | 30 | 8 | 3999.2 | 3,897 | 1,643 | 1,835 | 372 | 1,165 | 122 | 51 | 70 | 16,754 | 84 | 4.84 | 2.62 | 1.84 | 0.84 | 12.8 | 7.0 | 1.27 | .272 | 4.13 | 8.77 |
| 19 |  | J. Smoltz | 2,098 | 356 | 157 | 113 | .581 | 356 | 3.35 | 47 | 14 | 0 | 2414.1 | 2,092 | 898 | 986 | 195 | 774 | 38 | 0 | 55 | 9,947 | 119 | 7.82 | 2.89 | 2.71 | 0.73 | 21.1 | 7.8 | 1.19 | .277 | 3.68 | 7.80 |
| 20 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 21 | | O. Hershiser | 2,013 | 509 | 204 | 149 | .578 | 465 | 3.46 | 68 | 25 | 5 | 3128.2 | 2,933 | 1,203 | 1,359 | 234 | 1,004 | 116 | 19 | 108 | 13,136 | 120 | 5.79 | 2.89 | 2.00 | 0.67 | 15.3 | 7.6 | 1.26 | .276 | 3.91 | 8.44 |
| 22 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 23 | | R. Reuschel | 1,944 | 540 | 206 | 184 | .528 | 514 | 3.38 | 98 | 23 | 5 | 3442.1 | 3,485 | 1,294 | 1,454 | 218 | 910 | 86 | 15 | 111 | 14,454 | 88 | 5.08 | 2.38 | 2.14 | 0.57 | 13.4 | 6.3 | 1.28 | .289 | 3.80 | 9.11 |
| 24 | | D. Darwin | 1,942 | 716 | 171 | 182 | .484 | 371 | 3.84 | 53 | 9 | 32 | 3016.2 | 2,951 | 1,286 | 1,432 | 321 | 874 | 81 | 171 | 101 | 12,716 | 52 | 5.79 | 2.61 | 2.22 | 0.96 | 15.3 | 6.9 | 1.27 | .277 | 4.27 | 8.80 |
| 25 | | B. Witt | 1,924 | 416 | 138 | 156 | .469 | 390 | 4.84 | 47 | 11 | 0 | 2421.2 | 2,457 | 1,301 | 1,426 | 246 | 1,350 | 36 | 13 | 36 | 10,810 | 126 | 7.15 | 5.02 | 1.43 | 0.91 | 17.8 | 12.5 | 1.57 | .305 | 5.30 | 9.13 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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