Between September 26, 1965 and September 5, 1996, Nolan Ryan fanned the most hitters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | S. Carlton | 4,118 | 728 | 329 | 244 | .574 | 707 | 3.22 | 254 | 55 | 2 | 5194.2 | 4,646 | 1,857 | 2,123 | 411 | 1,825 | 52 | 9 | 149 | 21,585 | 178 | 7.13 | 3.16 | 2.26 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 3 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 4 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 5 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 6 | | P. Niekro | 3,286 | 815 | 316 | 271 | .538 | 715 | 3.35 | 245 | 45 | 23 | 5316.1 | 4,957 | 1,980 | 2,295 | 476 | 1,777 | 120 | 61 | 83 | 22,296 | 217 | 5.56 | 3.01 | 1.85 | 0.81 | 14.7 | 8.0 | 1.27 | .269 | 3.89 | 8.39 |
| 7 | | F. Jenkins | 3,185 | 658 | 283 | 225 | .557 | 594 | 3.34 | 267 | 49 | 6 | 4490.1 | 4,136 | 1,666 | 1,850 | 482 | 995 | 84 | 32 | 117 | 18,365 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.29 |
| 8 | | G. Perry | 3,137 | 645 | 290 | 235 | .552 | 634 | 3.05 | 291 | 51 | 3 | 4830.0 | 4,432 | 1,636 | 1,893 | 350 | 1,224 | 95 | 7 | 134 | 19,748 | 137 | 5.85 | 2.28 | 2.56 | 0.65 | 15.9 | 6.2 | 1.17 | .273 | 3.53 | 8.26 |
| 9 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 10 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 11 |  | R. Clemens | 2,540 | 378 | 190 | 109 | .635 | 377 | 3.05 | 98 | 37 | 0 | 2737.1 | 2,330 | 929 | 1,031 | 190 | 840 | 86 | 0 | 43 | 11,229 | 71 | 8.35 | 2.76 | 3.02 | 0.62 | 22.6 | 7.5 | 1.16 | .283 | 3.39 | 7.66 |
| 12 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 13 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 14 | | M. Langston | 2,335 | 401 | 172 | 146 | .541 | 398 | 3.85 | 81 | 18 | 0 | 2772.0 | 2,486 | 1,186 | 1,309 | 283 | 1,190 | 45 | 1 | 26 | 11,682 | 83 | 7.58 | 3.86 | 1.96 | 0.92 | 20.0 | 10.2 | 1.33 | .281 | 4.25 | 8.07 |
| 15 | | D. Eckersley | 2,327 | 953 | 192 | 164 | .539 | 361 | 3.48 | 100 | 20 | 349 | 3183.0 | 2,968 | 1,232 | 1,333 | 331 | 722 | 70 | 510 | 87 | 13,102 | 26 | 6.58 | 2.04 | 3.22 | 0.94 | 17.8 | 5.5 | 1.16 | .273 | 3.77 | 8.39 |
| 16 | | M. Lolich | 2,322 | 468 | 181 | 164 | .525 | 410 | 3.43 | 174 | 33 | 5 | 3036.1 | 2,815 | 1,156 | 1,284 | 285 | 911 | 69 | 25 | 64 | 12,623 | 103 | 6.88 | 2.70 | 2.55 | 0.84 | 18.4 | 7.2 | 1.23 | .280 | 3.81 | 8.34 |
| 17 | | V. Blue | 2,175 | 502 | 209 | 161 | .565 | 473 | 3.27 | 143 | 37 | 2 | 3343.1 | 2,939 | 1,213 | 1,357 | 263 | 1,185 | 23 | 11 | 61 | 13,838 | 103 | 5.85 | 3.19 | 1.84 | 0.71 | 15.7 | 8.6 | 1.23 | .263 | 3.65 | 7.91 |
| 18 | | L. Tiant | 2,159 | 513 | 208 | 157 | .570 | 438 | 3.31 | 168 | 44 | 13 | 3163.0 | 2,815 | 1,163 | 1,271 | 313 | 991 | 44 | 44 | 48 | 13,042 | 21 | 6.14 | 2.82 | 2.18 | 0.89 | 16.6 | 7.6 | 1.20 | .262 | 3.62 | 8.01 |
| 19 | | J. Palmer | 2,143 | 532 | 263 | 148 | .640 | 515 | 2.84 | 211 | 53 | 3 | 3858.2 | 3,277 | 1,216 | 1,348 | 297 | 1,257 | 36 | 8 | 36 | 15,734 | 83 | 5.00 | 2.93 | 1.70 | 0.69 | 13.6 | 8.0 | 1.18 | .248 | 3.14 | 7.64 |
| 20 | | D. Martinez | 2,070 | 630 | 240 | 182 | .569 | 548 | 3.63 | 121 | 29 | 6 | 3859.2 | 3,723 | 1,556 | 1,736 | 356 | 1,117 | 112 | 40 | 64 | 16,119 | 82 | 4.83 | 2.60 | 1.85 | 0.83 | 12.8 | 6.9 | 1.25 | .270 | 4.05 | 8.68 |
| 21 | | T. John | 2,052 | 691 | 273 | 213 | .562 | 657 | 3.34 | 155 | 44 | 1 | 4420.2 | 4,505 | 1,640 | 1,888 | 279 | 1,161 | 96 | 17 | 91 | 18,468 | 173 | 4.18 | 2.36 | 1.77 | 0.57 | 11.1 | 6.3 | 1.28 | .284 | 3.84 | 9.17 |
| 22 | | R. Reuschel | 2,015 | 557 | 214 | 191 | .528 | 529 | 3.37 | 102 | 26 | 5 | 3548.1 | 3,588 | 1,330 | 1,494 | 221 | 935 | 88 | 16 | 117 | 14,888 | 89 | 5.11 | 2.37 | 2.16 | 0.56 | 13.5 | 6.3 | 1.27 | .290 | 3.79 | 9.10 |
| 23 | | F. Valenzuela | 2,004 | 431 | 170 | 140 | .548 | 402 | 3.49 | 112 | 31 | 2 | 2822.1 | 2,593 | 1,096 | 1,232 | 212 | 1,096 | 20 | 10 | 65 | 11,899 | 115 | 6.39 | 3.49 | 1.83 | 0.68 | 16.8 | 9.2 | 1.31 | .278 | 3.93 | 8.27 |
| 24 | | D. Gooden | 1,992 | 331 | 168 | 91 | .649 | 329 | 3.21 | 68 | 24 | 1 | 2329.1 | 2,049 | 830 | 912 | 141 | 733 | 50 | 1 | 35 | 9,598 | 54 | 7.70 | 2.83 | 2.72 | 0.54 | 20.8 | 7.6 | 1.19 | .286 | 3.52 | 7.92 |
| 25 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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