Between September 9, 1990 and May 3, 2019, Randy Johnson struck out the most batters, with 4,554 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,554 | 557 | 280 | 145 | .659 | 543 | 3.22 | 93 | 35 | 2 | 3757.2 | 3,036 | 1,346 | 1,512 | 373 | 1,290 | 183 | 6 | 34 | 15,435 | 96 | 10.91 | 3.09 | 3.53 | 0.89 | 29.5 | 8.4 | 1.15 | .295 | 3.62 | 7.27 |
| 2 |  | R. Clemens | 3,253 | 504 | 239 | 133 | .642 | 503 | 3.22 | 53 | 21 | 0 | 3409.2 | 2,908 | 1,221 | 1,350 | 261 | 1,157 | 120 | 0 | 44 | 14,100 | 104 | 8.59 | 3.05 | 2.81 | 0.69 | 23.1 | 8.2 | 1.19 | .284 | 3.56 | 7.68 |
| 3 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 4 |  | C. Schilling | 3,077 | 534 | 215 | 142 | .602 | 431 | 3.44 | 83 | 20 | 20 | 3200.0 | 2,937 | 1,224 | 1,286 | 342 | 680 | 51 | 68 | 42 | 13,014 | 69 | 8.65 | 1.91 | 4.53 | 0.96 | 23.6 | 5.2 | 1.13 | .293 | 3.62 | 8.26 |
| 5 |  | CC Sabathia | 3,002 | 542 | 247 | 154 | .616 | 542 | 3.69 | 38 | 12 | 0 | 3490.1 | 3,307 | 1,432 | 1,567 | 359 | 1,066 | 120 | 0 | 44 | 14,603 | 74 | 7.74 | 2.75 | 2.82 | 0.93 | 20.6 | 7.3 | 1.25 | .293 | 4.04 | 8.53 |
| 6 |  | G. Maddux | 2,857 | 609 | 298 | 176 | .629 | 609 | 3.04 | 84 | 28 | 0 | 4132.2 | 3,846 | 1,396 | 1,566 | 298 | 692 | 113 | 0 | 125 | 16,672 | 53 | 6.22 | 1.51 | 4.13 | 0.65 | 17.1 | 4.2 | 1.10 | .279 | 3.41 | 8.38 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | J. Verlander | 2,759 | 426 | 208 | 124 | .627 | 426 | 3.37 | 24 | 8 | 0 | 2803.0 | 2,425 | 1,051 | 1,136 | 279 | 819 | 95 | 0 | 27 | 11,519 | 83 | 8.86 | 2.63 | 3.37 | 0.90 | 24.0 | 7.1 | 1.16 | .284 | 3.65 | 7.79 |
| 9 |  | J. Smoltz | 2,726 | 653 | 186 | 128 | .592 | 411 | 3.29 | 42 | 14 | 154 | 3000.0 | 2,665 | 1,097 | 1,182 | 246 | 833 | 52 | 204 | 75 | 12,295 | 125 | 8.18 | 2.50 | 3.27 | 0.74 | 22.2 | 6.8 | 1.17 | .287 | 3.55 | 8.00 |
| 10 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 11 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 12 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 13 |  | M. Scherzer | 2,511 | 345 | 160 | 86 | .650 | 336 | 3.24 | 10 | 5 | 0 | 2164.0 | 1,786 | 778 | 840 | 240 | 592 | 80 | 2 | 18 | 8,774 | 65 | 10.44 | 2.46 | 4.24 | 1.00 | 28.6 | 6.7 | 1.10 | .289 | 3.49 | 7.43 |
| 14 |  | F. Hernandez | 2,496 | 410 | 169 | 130 | .565 | 409 | 3.35 | 25 | 11 | 0 | 2689.1 | 2,438 | 1,001 | 1,116 | 252 | 784 | 103 | 0 | 16 | 11,094 | 154 | 8.35 | 2.62 | 3.18 | 0.84 | 22.5 | 7.1 | 1.20 | .293 | 3.73 | 8.16 |
| 15 |  | Z. Greinke | 2,481 | 462 | 192 | 119 | .617 | 421 | 3.38 | 16 | 5 | 1 | 2707.1 | 2,520 | 1,018 | 1,095 | 279 | 645 | 65 | 8 | 23 | 11,088 | 84 | 8.25 | 2.14 | 3.85 | 0.93 | 22.4 | 5.8 | 1.17 | .294 | 3.64 | 8.38 |
| 16 | | C. Hamels | 2,452 | 401 | 159 | 114 | .582 | 400 | 3.40 | 17 | 7 | 0 | 2589.2 | 2,308 | 977 | 1,051 | 297 | 722 | 94 | 0 | 42 | 10,636 | 56 | 8.52 | 2.51 | 3.40 | 1.03 | 23.1 | 6.8 | 1.17 | .284 | 3.65 | 8.02 |
| 17 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 18 |  | C. Kershaw | 2,302 | 322 | 154 | 69 | .691 | 320 | 2.40 | 25 | 15 | 0 | 2122.1 | 1,587 | 565 | 617 | 149 | 541 | 31 | 1 | 27 | 8,349 | 81 | 9.76 | 2.29 | 4.26 | 0.63 | 27.6 | 6.5 | 1.00 | .270 | 2.62 | 6.73 |
| 19 | | T. Glavine | 2,302 | 582 | 275 | 163 | .628 | 582 | 3.40 | 48 | 21 | 0 | 3800.0 | 3,668 | 1,436 | 1,567 | 303 | 1,300 | 52 | 0 | 121 | 15,963 | 52 | 5.45 | 3.08 | 1.77 | 0.72 | 14.4 | 8.1 | 1.31 | .280 | 3.71 | 8.69 |
| 20 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 21 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 22 |  | J. Lester | 2,217 | 386 | 179 | 99 | .644 | 385 | 3.48 | 15 | 4 | 0 | 2392.0 | 2,200 | 925 | 1,000 | 235 | 775 | 79 | 0 | 8 | 9,933 | 58 | 8.34 | 2.92 | 2.86 | 0.88 | 22.3 | 7.8 | 1.24 | .297 | 3.76 | 8.28 |
| 23 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 24 | | K. Brown | 2,189 | 427 | 185 | 124 | .599 | 417 | 3.24 | 58 | 15 | 0 | 2857.0 | 2,698 | 1,029 | 1,175 | 183 | 763 | 131 | 1 | 37 | 11,858 | 91 | 6.90 | 2.40 | 2.87 | 0.58 | 18.5 | 6.4 | 1.21 | .293 | 3.70 | 8.50 |
| 25 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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