Before April 14, 2018, Reggie Jackson had the most strikeouts, with 2,596 strikeouts.

Interpreted as:

most strikeouts by a player through April 13, 2018

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reggie Jackson R. Jackson	2,596	2,820	9,864	1,551	2,584	463	49	563	1,702	1,376	96	228	115	11,417	4,834	1,075	13	68	164	183	.262	.356	.490	.846
2	Jim Thome J. Thome	2,548	2,543	8,422	1,583	2,328	451	26	612	1,699	1,747	69	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956
3	Adam Dunn A. Dunn	2,379	2,001	6,883	1,097	1,631	334	10	462	1,168	1,317	86	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854
4	Sammy Sosa S. Sosa	2,306	2,354	8,813	1,475	2,408	379	45	609	1,667	929	59	234	107	9,896	4,704	1,033	17	78	154	202	.273	.344	.534	.878
5	Alex Rodriguez A. Rodriguez	2,287	2,784	10,566	2,021	3,115	548	31	696	2,086	1,338	176	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930
6	Andres Galarraga A. Galarraga	2,003	2,257	8,096	1,195	2,333	444	32	399	1,425	583	178	128	81	8,916	4,038	875	1	58	106	178	.288	.347	.499	.846
7	Jose Canseco J. Canseco	1,942	1,887	7,057	1,186	1,877	340	14	462	1,407	906	84	200	88	8,129	3,631	816	1	81	64	178	.266	.353	.515	.867
8	Willie Stargell W. Stargell	1,936	2,360	7,927	1,195	2,232	423	55	475	1,540	937	79	17	16	9,027	4,190	953	9	75	227	144	.282	.360	.529	.889
9	Mike Cameron M. Cameron	1,901	1,955	6,839	1,064	1,700	383	59	278	968	867	87	297	83	7,884	3,035	720	31	60	19	114	.249	.338	.444	.782
10	Mike Schmidt M. Schmidt	1,883	2,404	8,352	1,506	2,234	408	59	548	1,595	1,507	79	174	91	10,062	4,404	1,015	16	108	201	156	.267	.380	.527	.908
11	Fred McGriff F. McGriff	1,882	2,460	8,757	1,349	2,490	441	24	493	1,550	1,305	39	72	38	10,174	4,458	958	2	71	171	226	.284	.377	.509	.886
12	Tony Perez T. Perez	1,867	2,777	9,778	1,272	2,732	505	79	379	1,652	925	43	49	33	10,861	4,532	963	9	106	150	264	.279	.341	.463	.804
13	Ryan Howard R. Howard	1,843	1,572	5,707	848	1,475	277	21	382	1,194	709	59	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859
14	Bobby Abreu B. Abreu	1,840	2,425	8,480	1,453	2,470	574	59	288	1,363	1,476	33	400	128	10,081	4,026	921	7	85	115	165	.291	.395	.475	.870
15	Derek Jeter D. Jeter	1,840	2,747	11,195	1,923	3,465	544	66	260	1,311	1,082	170	358	97	12,602	4,921	870	97	58	39	287	.310	.377	.440	.817
16	Dave Kingman D. Kingman	1,816	1,941	6,677	901	1,575	240	25	442	1,210	608	53	85	49	7,429	3,191	707	16	75	72	139	.236	.302	.478	.780
17	Manny Ramirez M. Ramirez	1,813	2,302	8,244	1,544	2,574	547	20	555	1,831	1,329	109	38	33	9,774	4,826	1,122	2	90	216	243	.312	.411	.585	.996
18	Mark Reynolds M. Reynolds	1,806	1,524	5,091	755	1,209	238	14	281	811	661	52	62	31	5,846	2,318	533	3	39	25	106	.237	.329	.455	.784
19	Alfonso Soriano A. Soriano	1,803	1,975	7,750	1,152	2,095	481	31	412	1,159	496	86	289	84	8,395	3,874	924	9	54	68	123	.270	.319	.500	.819
20	Carlos Beltran C. Beltran	1,795	2,586	9,768	1,582	2,725	565	78	435	1,587	1,084	51	312	49	11,031	4,751	1,078	18	110	104	203	.279	.350	.486	.837
21	Ken Griffey Jr. K. Griffey Jr.	1,779	2,671	9,801	1,662	2,781	524	38	630	1,836	1,312	81	184	69	11,304	5,271	1,192	8	102	246	199	.284	.370	.538	.907
22	Bobby Bonds B. Bonds	1,757	1,849	7,043	1,258	1,886	302	66	332	1,024	914	53	461	169	8,090	3,316	700	16	64	75	105	.268	.353	.471	.824
23	Craig Biggio C. Biggio	1,753	2,850	10,876	1,844	3,060	668	55	291	1,175	1,160	285	414	124	12,503	4,711	1,014	101	81	68	150	.281	.363	.433	.796
24	David Ortiz D. Ortiz	1,750	2,408	8,640	1,419	2,472	632	19	541	1,768	1,319	38	17	9	10,091	4,765	1,192	2	92	209	236	.286	.380	.552	.931
25	Andruw Jones A. Jones	1,748	2,196	7,599	1,204	1,933	383	36	434	1,289	891	97	152	59	8,664	3,690	853	6	71	69	192	.254	.337	.486	.823

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StatMuse has game-level data for strikeouts going back to the 1916 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Before April 14, 2018, Reggie Jackson had the most strikeouts, with 2,596 strikeouts.

Interpreted as:

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