The Pittsburgh Pirates have a run differential of -759 runs in the regular-season and playoffs since 2020.
| TEAM | DIFF | SEASON | G | W% | W | L | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Pirates | -79 | 2020 | 60 | .317 | 19 | 41 | 1,932 | 219 | 425 | 76 | 6 | 59 | 210 | 167 | 11 | 521 | 16 | 11 | 2,132 | 690 | 141 | 7 | 15 | 6 | 34 | .220 | .284 | .357 | .641 |
| 2 | | Pirates | -224 | 2021 | 162 | .377 | 61 | 101 | 5,336 | 609 | 1,261 | 240 | 35 | 124 | 570 | 529 | 49 | 1,328 | 60 | 30 | 5,982 | 1,943 | 399 | 31 | 37 | 24 | 102 | .236 | .309 | .364 | .673 |
| 3 | | Pirates | -226 | 2022 | 162 | .383 | 62 | 100 | 5,331 | 591 | 1,186 | 221 | 29 | 158 | 555 | 476 | 54 | 1,497 | 89 | 32 | 5,912 | 1,939 | 408 | 19 | 32 | 14 | 96 | .222 | .291 | .364 | .655 |
| 4 | | Pirates | -98 | 2023 | 162 | .469 | 76 | 86 | 5,406 | 692 | 1,293 | 287 | 31 | 159 | 662 | 556 | 58 | 1,464 | 117 | 41 | 6,088 | 2,119 | 477 | 25 | 43 | 9 | 92 | .239 | .315 | .392 | .707 |
| 5 | | Pirates | -74 | 2024 | 162 | .469 | 76 | 86 | 5,477 | 665 | 1,283 | 236 | 17 | 160 | 643 | 485 | 60 | 1,506 | 106 | 19 | 6,085 | 2,033 | 413 | 16 | 47 | 14 | 100 | .234 | .301 | .371 | .672 |
| 6 | | Pirates | -58 | 2025 | 119 | .429 | 51 | 68 | 3,955 | 426 | 923 | 165 | 17 | 83 | 412 | 381 | 38 | 1,034 | 90 | 27 | 4,409 | 1,371 | 265 | 9 | 26 | 15 | 90 | .233 | .305 | .347 | .652 |
| Total | -759 | 827 | .417 | 345 | 482 | 27,437 | 3,202 | 6,371 | 1,225 | 135 | 743 | 3,052 | 2,594 | 270 | 7,350 | 478 | 160 | 30,608 | 10,095 | 2,103 | 107 | 200 | 82 | 514 | .232 | .303 | .368 | .671 |
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