9 players were tied for playing the most seasons with 375+ strikeouts, with 1 season. The first three are Nolan Ryan, Sandy Koufax and Matt Kilroy.
| NAME | SEAS | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 1 | 383 | 41 | 21 | 16 | .568 | 39 | 2.87 | 26 | 4 | 1 | 326.0 | 238 | 104 | 113 | 18 | 162 | 7 | 2 | 2 | 1,355 | 15 | 10.57 | 4.47 | 2.36 | 0.50 | 28.3 | 12.0 | 1.23 | .280 | 3.12 | 80 | 2.48 | 69 | 6.57 | 40.9 |
| 2 |  | S. Koufax | 1 | 382 | 43 | 26 | 8 | .765 | 41 | 2.04 | 27 | 8 | 2 | 335.2 | 216 | 76 | 90 | 26 | 71 | 5 | 2 | 4 | 1,297 | 11 | 10.24 | 1.90 | 5.38 | 0.70 | 29.5 | 5.5 | 0.86 | .234 | 2.41 | 63 | 1.93 | 61 | 5.79 | 47.9 |
| 3 |  | M. Kilroy | 1 | 513 | 68 | 29 | 34 | .460 | 68 | 3.37 | 66 | 5 | 0 | 583.0 | 476 | 218 | 350 | 10 | 182 | 19 | 0 | 2,469 | 61 | 7.92 | 2.81 | 2.82 | 0.15 | 20.8 | 7.4 | 1.13 | .267 | 5.40 | 100 | 2.60 | 77 | 7.35 | 47 | |
| 4 | | T. Ramsey | 1 | 499 | 67 | 38 | 27 | .585 | 67 | 2.45 | 66 | 3 | 0 | 588.2 | 447 | 160 | 297 | 3 | 207 | 12 | 0 | 2,477 | 35 | 7.63 | 3.16 | 2.41 | 0.05 | 20.1 | 8.4 | 1.11 | .253 | 4.54 | 71 | 2.59 | 76 | 6.83 | 54.7 | |
| 5 |  | C. Buffinton | 1 | 417 | 67 | 48 | 16 | .750 | 67 | 2.15 | 63 | 8 | 0 | 587.0 | 506 | 140 | 225 | 15 | 76 | 0 | 2,383 | 24 | 6.39 | 1.17 | 5.49 | 0.23 | 17.5 | 3.2 | 0.99 | 3.45 | 74 | 2.57 | 77 | 7.76 | 46.8 | |||
| 6 | | H. Daily | 1 | 483 | 58 | 28 | 28 | .500 | 58 | 2.43 | 56 | 5 | 0 | 500.2 | 446 | 135 | 268 | 11 | 72 | 0 | 2,076 | 50 | 8.68 | 1.29 | 6.71 | 0.20 | 23.3 | 3.5 | 1.03 | 4.82 | 81 | 2.06 | 79 | 8.02 | 27.4 | |||
| 7 | | G. Hecker | 1 | 385 | 75 | 52 | 20 | .722 | 73 | 1.80 | 72 | 6 | 0 | 670.2 | 526 | 134 | 230 | 4 | 56 | 16 | 2 | 2,649 | 27 | 5.17 | 0.75 | 6.88 | 0.05 | 14.5 | 2.1 | 0.87 | .239 | 3.09 | 57 | 2.53 | 80 | 7.06 | 43 | |
| 8 | | O. Hoss Radbourn | 1 | 441 | 75 | 59 | 12 | .831 | 73 | 1.38 | 73 | 11 | 2 | 678.2 | 528 | 104 | 216 | 18 | 98 | 2 | 2,672 | 34 | 5.85 | 1.30 | 4.50 | 0.24 | 16.5 | 3.7 | 0.92 | 2.86 | 48 | 2.75 | 84 | 7.00 | 31.9 | |||
| 9 | | D. Shaw | 1 | 451 | 67 | 30 | 33 | .476 | 66 | 2.30 | 60 | 5 | 0 | 543.1 | 446 | 139 | 281 | 9 | 109 | 1 | 2,244 | 24 | 7.47 | 1.81 | 4.14 | 0.15 | 20.1 | 4.9 | 1.02 | 4.65 | 77 | 2.43 | 81 | 7.39 | 29 |
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