Between the 1900 and 1909 seasons, Christy Mathewson won the most games, with 236 wins.

Interpreted as:

player with most regular-season wins in the 00's

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Christy Mathewson C. Mathewson	236	112	.678	389	345	1.98	1,799	282	61	16	2974.2	2,435	654	952	37	644	50	39	11,687	90	5.44	1.95	2.79	0.11	15.4	5.5	1.04	.262	2.88	71	2.12	73	7.37	248.9
2	Cy Young C. Young	230	146	.612	403	366	2.12	1,565	337	45	9	3344.0	2,951	787	1,126	45	394	68	34	12,862	48	4.21	1.06	3.97	0.12	12.2	3.1	1.00	.269	3.03	73	2.17	75	7.94	274.6
3	Joe McGinnity J. McGinnity	218	126	.634	417	340	2.65	994	276	28	22	3075.0	2,918	907	1,272	49	719	153	66	12,613	26	2.91	2.10	1.38	0.14	7.9	5.7	1.18	.268	3.72	86	2.98	95	8.54	59.4
4	Jack Chesbro J. Chesbro	192	123	.610	373	315	2.61	1,237	245	35	5	2747.2	2,482	796	1,107	36	631	102	50	10,973	57	4.05	2.07	1.96	0.12	11.3	5.8	1.13	.273	3.63	89	2.59	89	8.13	107.9
5	Vic Willis V. Willis	188	172	.522	398	372	2.57	1,304	312	43	6	3130.1	2,856	895	1,238	49	886	96	26	12,655	70	3.75	2.55	1.47	0.14	10.3	7.0	1.20	.272	3.56	89	2.81	94	8.21	58
6	Eddie Plank E. Plank	186	121	.606	334	314	2.42	1,342	263	36	1	2666.0	2,360	716	955	26	599	140	16	10,645	57	4.53	2.02	2.24	0.09	12.6	5.6	1.11	.273	3.22	83	2.42	86	7.97	120.4
7	Rube Waddell R. Waddell	183	139	.568	385	328	2.11	2,251	251	49	3	2835.1	2,343	666	1,000	32	772	105	46	11,197	72	7.15	2.45	2.92	0.10	20.1	6.9	1.10	.288	3.17	74	1.98	70	7.44	258.7
8	Sam Leever S. Leever	166	72	.697	306	249	2.33	678	200	35	8	2137.2	1,966	554	777	20	435	70	48	8,539	38	2.85	1.83	1.56	0.08	7.9	5.1	1.12	.265	3.27	81	2.72	92	8.28	62.6
9	Jack Powell J. Powell	160	163	.495	377	334	2.88	1,209	277	32	14	2876.2	2,720	921	1,241	73	638	69	40	11,532	47	3.78	2.00	1.89	0.23	10.5	5.5	1.17	.277	3.88	98	2.75	97	8.51	28.1
10	George Mullin G. Mullin	157	134	.540	330	298	2.66	1,091	258	25	6	2592.1	2,434	765	1,116	19	833	78	30	10,636	67	3.79	2.89	1.31	0.07	10.3	7.8	1.26	.280	3.87	97	2.71	101	8.45	-5.9
11	Addie Joss A. Joss	155	92	.628	273	248	1.87	871	225	44	5	2219.2	1,792	461	695	17	346	56	22	8,479	28	3.53	1.40	2.52	0.07	10.3	4.1	0.96	.247	2.82	69	2.25	86	7.27	83.5
12	Doc White D. White	154	115	.572	309	278	2.20	1,105	215	38	2	2315.0	2,022	565	806	26	499	86	27	9,157	50	4.30	1.94	2.21	0.10	12.1	5.4	1.09	.268	3.13	85	2.42	95	7.86	22.5
13	Bill Donovan B. Donovan	154	112	.579	295	273	2.57	1,293	246	31	7	2426.0	2,118	694	938	21	838	71	22	9,906	51	4.80	3.11	1.54	0.08	13.1	8.5	1.22	.273	3.48	92	2.68	97	7.86	28.5
14	Deacon Phillippe D. Phillippe	154	90	.631	296	243	2.50	828	204	24	7	2158.1	2,071	600	842	27	288	49	47	8,565	42	3.45	1.20	2.88	0.11	9.7	3.4	1.09	.277	3.51	85	2.45	80	8.64	143.9
15	Bill Dinneen B. Dinneen	147	141	.510	325	290	2.82	953	254	24	7	2565.1	2,369	805	1,080	66	635	49	31	10,285	49	3.34	2.23	1.50	0.23	9.3	6.2	1.17	.268	3.79	95	2.96	101	8.31	8.2
16	Mordecai Brown M. Brown	144	65	.689	246	195	1.63	799	170	41	19	1827.2	1,443	331	517	16	356	35	49	7,000	34	3.93	1.75	2.24	0.08	11.4	5.1	0.98	.246	2.55	61	2.22	80	7.11	103.8
17	Al Orth A. Orth	138	143	.491	315	284	3.21	749	229	25	4	2393.2	2,429	853	1,134	51	439	61	29	9,701	34	2.82	1.65	1.71	0.19	7.7	4.5	1.20	.283	4.26	105	2.84	94	9.13	55.6
18	Jesse Tannehill J. Tannehill	138	80	.633	248	229	2.59	738	185	25	2	1935.1	1,880	557	779	32	320	95	19	7,771	20	3.43	1.49	2.31	0.15	9.5	4.1	1.14	.281	3.62	90	2.68	93	8.74	52.3
19	Jack Taylor J. Taylor	129	118	.522	265	243	2.49	584	235	19	5	2230.1	2,092	616	960	35	490	71	22	9,049	37	2.36	1.98	1.19	0.14	6.5	5.4	1.16	.261	3.87	85	3.04	102	8.44	-21.1
20	Chick Fraser C. Fraser	118	134	.468	288	251	3.29	792	219	17	5	2204.2	2,175	805	1,155	42	836	117	34	9,342	72	3.23	3.41	0.95	0.17	8.5	8.9	1.37	.282	4.71	108	3.40	110	8.88	-72.2
21	Harry Howell H. Howell	116	138	.457	309	255	2.60	925	221	20	5	2337.0	2,165	676	1,014	26	595	86	49	9,424	44	3.56	2.29	1.55	0.10	9.8	6.3	1.18	.275	3.91	89	2.70	97	8.34	23.8
22	Dummy Taylor D. Taylor	116	106	.523	274	237	2.75	767	160	21	3	1916.1	1,877	585	870	38	551	72	30	7,952	47	3.60	2.59	1.39	0.18	9.6	6.9	1.27	.282	4.09	94	2.99	100	8.82	-5.8
23	Togie Pittinger T. Pittinger	115	113	.504	262	227	3.10	832	187	23	3	2040.2	2,017	702	985	39	734	96	30	8,579	43	3.67	3.24	1.13	0.17	9.7	8.6	1.35	.288	4.34	103	3.27	107	8.90	-43.6
24	Tully Sparks T. Sparks	113	128	.469	282	249	2.69	723	194	19	8	2150.2	2,036	642	945	30	542	75	30	8,716	20	3.03	2.27	1.33	0.13	8.3	6.2	1.20	.273	3.95	95	2.83	97	8.52	14.1
25	Ed Walsh E. Walsh	110	63	.636	234	175	1.68	901	138	36	15	1642.1	1,276	307	464	7	312	34	54	6,282	51	4.94	1.71	2.89	0.04	14.3	5.0	0.97	.252	2.54	70	1.83	80	6.99	74.3