David Ortiz has crushed the most career homers by a designated hitter, with 531 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	David Ortiz D. Ortiz	531	2,307	8,313	1,362	2,379	609	19	1,716	1,278	33	1,659	16	9	9,714	4,619	1,159	2	88	206	227	.286	.380	.556	.936	1705	551.7	.393	141	479.3
2	Frank Thomas F. Thomas	296	1,404	4,937	813	1,385	280	6	959	926	62	927	15	10	5,985	2,565	582	0	60	63	123	.281	.396	.520	.916	1057	318	.394	139	296
3	Shohei Ohtani S. Ohtani	280	1,018	3,730	708	1,050	192	45	669	541	25	1,104	165	43	4,316	2,172	517	0	20	88	49	.282	.374	.582	.957	807	292.3	.397	156	288.6
4	Nelson Cruz N. Cruz	263	1,099	4,020	596	1,101	179	6	743	429	64	1,041	16	7	4,551	2,081	448	0	38	50	116	.274	.350	.518	.868	727	188.9	.366	135	191.8
5	Edgar Martinez E. Martinez	251	1,445	5,082	877	1,593	369	6	1,006	995	65	927	26	16	6,201	2,727	626	1	58	95	138	.313	.428	.537	.965	1206	428.4	.414	152	418.4
6	Harold Baines H. Baines	244	1,838	6,154	807	1,789	306	11	1,039	799	7	902	5	16	7,015	2,849	561	1	54	127	201	.291	.370	.463	.833	1048	212.1	.363	122	188.7
7	Don Baylor D. Baylor	225	1,372	4,878	746	1,235	220	8	789	488	179	692	87	49	5,620	2,146	453	6	69	60	124	.253	.339	.440	.779	749	114.4	.345	116	101.6
8	Edwin Encarnacion E. Encarnacion	220	929	3,365	545	878	166	2	636	474	45	726	31	7	3,925	1,708	388	0	41	29	94	.261	.356	.508	.864	619	161.2	.367	131	141.8
9	Jose Canseco J. Canseco	217	855	3,171	542	844	155	5	627	457	39	882	66	29	3,700	1,660	377	0	33	27	83	.266	.362	.523	.886	607	139.3	.379	123	114.8
10	Travis Hafner T. Hafner	213	1,183	4,058	619	1,107	250	13	731	598	90	976	11	7	4,775	2,022	476	0	29	81	86	.273	.376	.498	.874	766	193.9	.374	132	189.5
11	Chili Davis C. Davis	206	1,249	4,365	646	1,227	227	6	771	716	9	893	35	26	5,136	2,084	439	1	45	98	127	.281	.380	.477	.858	808	187.4	.373	124	158
12	Giancarlo Stanton G. Stanton	183	722	2,638	359	642	108	1	484	306	18	895	6	1	2,982	1,301	292	0	20	17	84	.243	.324	.493	.817	435	81.4	.347	124	84.4
13	Jim Thome J. Thome	182	805	2,503	432	663	127	2	506	490	19	786	1	1	3,032	1,340	311	0	20	46	59	.265	.387	.535	.922	530	165.9	.393	139	145.9
14	J.D. Martinez	179	870	3,324	506	936	222	11	595	353	26	928	10	1	3,738	1,717	412	0	35	31	110	.282	.352	.517	.868	605	156.4	.365	130	137.6
15	Yordan Alvarez Y. Alvarez	170	677	2,455	429	728	156	6	493	346	40	566	9	2	2,867	1,406	332	0	26	42	60	.297	.389	.573	.961	549	206.4	.402	163	212.4
16	Hal McRae H. McRae	155	1,605	5,750	779	1,698	393	54	891	535	64	612	92	63	6,432	2,664	602	17	66	56	140	.295	.358	.463	.821	940	223.6	.364	126	193.1
17	Kendrys Morales K. Morales	154	980	3,550	413	933	185	3	536	306	35	748	2	4	3,916	1,586	342	0	25	23	125	.263	.325	.447	.772	502	53.8	.332	110	46.8
18	Marcell Ozuna M. Ozuna	141	635	2,321	335	624	112	1	384	294	11	630	3	1	2,644	1,161	254	0	18	8	58	.269	.351	.500	.852	425	110.6	.364	131	102.3
19	Cliff Johnson C. Johnson	138	922	2,722	366	718	134	5	488	370	36	479	8	10	3,158	1,276	277	3	27	31	53	.264	.356	.469	.825	469	112.3	.365	126	98
20	Andre Thornton A. Thornton	127	806	2,857	387	728	120	2	481	432	7	436	27	18	3,344	1,233	249	5	43	45	81	.255	.350	.432	.781	449	72.3	.346	113	49.1
21	Oscar Gamble O. Gamble	121	717	2,115	339	594	87	12	354	303	20	257	18	16	2,455	1,068	220	4	13	30	27	.281	.374	.505	.879	406	129.6	.388	142	120.9
22	Paul Molitor P. Molitor	119	1,261	5,054	843	1,613	309	53	756	558	24	557	187	40	5,713	2,385	481	16	61	61	112	.319	.385	.472	.857	909	219.6	.375	126	183.4
23	Victor Martinez V. Martinez	115	969	3,558	405	1,033	188	0	540	319	25	409	4	4	3,942	1,566	303	0	40	67	131	.290	.349	.440	.789	521	73.7	.339	113	56.4
24	Jorge Soler J. Soler	113	484	1,735	273	435	99	2	280	226	25	520	5	1	1,999	877	214	0	13	7	48	.251	.343	.505	.849	314	69.9	.358	125	63.6
25	Billy Butler B. Butler	111	1,097	3,902	437	1,107	226	4	557	373	27	659	4	3	4,336	1,674	341	0	34	48	155	.284	.348	.429	.777	564	70.5	.337	110	52