Since 1937, Randy Johnson and Nolan Ryan are tied for playing the most seasons with 320+ strikeouts, with 5 seasons.
| NAME | SEAS | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 5 | 1,746 | 174 | 100 | 38 | .725 | 173 | 2.63 | 41 | 17 | 0 | 1274.1 | 990 | 373 | 429 | 121 | 374 | 60 | 1 | 8 | 5,123 | 27 | 12.33 | 2.64 | 4.67 | 0.85 | 34.1 | 7.3 | 1.07 | .308 | 3.03 | 58 | 2.59 | 57 | 6.99 | 271.4 |
| 2 |  | N. Ryan | 5 | 1,747 | 198 | 98 | 82 | .544 | 195 | 2.84 | 115 | 27 | 1 | 1526.0 | 1,016 | 481 | 547 | 75 | 908 | 40 | 3 | 18 | 6,369 | 68 | 10.30 | 5.36 | 1.92 | 0.44 | 27.4 | 14.3 | 1.26 | .261 | 3.23 | 83 | 2.79 | 80 | 5.99 | 122.2 |
| 3 |  | G. Cole | 1 | 326 | 33 | 20 | 5 | .800 | 33 | 2.50 | 0 | 0 | 0 | 212.1 | 142 | 59 | 66 | 29 | 48 | 3 | 0 | 0 | 817 | 4 | 13.82 | 2.03 | 6.79 | 1.23 | 39.9 | 5.9 | 0.89 | .275 | 2.80 | 55 | 2.63 | 58 | 6.02 | 45 |
| 4 |  | S. Koufax | 1 | 382 | 43 | 26 | 8 | .765 | 41 | 2.04 | 27 | 8 | 2 | 335.2 | 216 | 76 | 90 | 26 | 71 | 5 | 2 | 4 | 1,297 | 11 | 10.24 | 1.90 | 5.38 | 0.70 | 29.5 | 5.5 | 0.86 | .234 | 2.41 | 63 | 1.93 | 61 | 5.79 | 47.9 |
| 5 |  | S. McDowell | 1 | 325 | 42 | 17 | 11 | .607 | 35 | 2.18 | 14 | 3 | 4 | 273.0 | 178 | 66 | 80 | 9 | 132 | 6 | 5 | 7 | 1,116 | 17 | 10.71 | 4.35 | 2.46 | 0.30 | 29.1 | 11.8 | 1.14 | .262 | 2.64 | 63 | 2.08 | 58 | 5.87 | 45.4 |
| 6 | | B. Feller | 1 | 348 | 48 | 26 | 15 | .634 | 42 | 2.18 | 36 | 10 | 4 | 371.1 | 277 | 90 | 101 | 11 | 153 | 3 | 5 | 1,512 | 3 | 8.43 | 3.71 | 2.27 | 0.27 | 23.0 | 10.1 | 1.16 | .267 | 2.45 | 65 | 2.16 | 65 | 6.71 | 48.3 |
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