Since 1937, Randy Johnson and Nolan Ryan are tied for playing the most seasons with 340+ strikeouts, with 3 seasons.
| NAME | SEAS | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3 | 1,083 | 105 | 57 | 22 | .722 | 104 | 2.54 | 23 | 7 | 0 | 770.0 | 590 | 217 | 249 | 72 | 217 | 33 | 1 | 6 | 3,074 | 17 | 12.66 | 2.54 | 4.99 | 0.84 | 35.2 | 7.1 | 1.05 | .310 | 2.91 | 55 | 2.47 | 53 | 6.90 | 182.2 |
| 2 |  | N. Ryan | 3 | 1,091 | 120 | 62 | 48 | .564 | 117 | 2.85 | 74 | 11 | 1 | 957.2 | 657 | 303 | 350 | 48 | 568 | 25 | 3 | 12 | 4,019 | 45 | 10.25 | 5.34 | 1.92 | 0.45 | 27.1 | 14.1 | 1.28 | .266 | 3.29 | 79 | 2.85 | 78 | 6.17 | 89 |
| 3 |  | S. Koufax | 1 | 382 | 43 | 26 | 8 | .765 | 41 | 2.04 | 27 | 8 | 2 | 335.2 | 216 | 76 | 90 | 26 | 71 | 5 | 2 | 4 | 1,297 | 11 | 10.24 | 1.90 | 5.38 | 0.70 | 29.5 | 5.5 | 0.86 | .234 | 2.41 | 63 | 1.93 | 61 | 5.79 | 47.9 |
| 4 |  | B. Feller | 1 | 348 | 48 | 26 | 15 | .634 | 42 | 2.18 | 36 | 10 | 4 | 371.1 | 277 | 90 | 101 | 11 | 153 | 3 | 5 | 1,512 | 3 | 8.43 | 3.71 | 2.27 | 0.27 | 23.0 | 10.1 | 1.16 | .267 | 2.45 | 65 | 2.16 | 65 | 6.71 | 48.3 |
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