Since 1937, Randy Johnson and Nolan Ryan are tied for playing the most seasons with 360+ strikeouts, with 2 seasons.
| NAME | SEAS | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 2 | 736 | 70 | 38 | 15 | .717 | 69 | 2.49 | 15 | 4 | 0 | 521.1 | 388 | 144 | 160 | 49 | 141 | 27 | 1 | 5 | 2,073 | 12 | 12.71 | 2.43 | 5.22 | 0.85 | 35.5 | 6.8 | 1.01 | .303 | 2.76 | 54 | 2.45 | 54 | 6.70 | 121.1 |
| 2 |  | N. Ryan | 2 | 750 | 83 | 43 | 32 | .573 | 80 | 2.88 | 52 | 7 | 1 | 658.2 | 459 | 211 | 240 | 36 | 364 | 16 | 3 | 5 | 2,747 | 24 | 10.25 | 4.97 | 2.06 | 0.49 | 27.3 | 13.3 | 1.25 | .268 | 3.28 | 83 | 2.73 | 77 | 6.27 | 61.1 |
| 3 |  | S. Koufax | 1 | 382 | 43 | 26 | 8 | .765 | 41 | 2.04 | 27 | 8 | 2 | 335.2 | 216 | 76 | 90 | 26 | 71 | 5 | 2 | 4 | 1,297 | 11 | 10.24 | 1.90 | 5.38 | 0.70 | 29.5 | 5.5 | 0.86 | .234 | 2.41 | 63 | 1.93 | 61 | 5.79 | 47.9 |
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