which pitcher has the most strikeouts all-time in the first inning

Randy Johnson has fanned the most career batters in the 1st inning, with 713 strikeouts.

		NAME	SO	G	H	HR	BB	HBP	IBB	K/BB
1		Randy Johnson R. Johnson	713	603	468	58	238	29	0	3.00
2		Roger Clemens R. Clemens	700	707	545	36	265	31	2	2.64
3		Nolan Ryan N. Ryan	647	621	499	34	401	18	4	1.61
4		Max Scherzer M. Scherzer	554	458	364	57	147	20	1	3.77
5		Justin Verlander J. Verlander	536	535	449	75	198	15	2	2.71
6		Greg Maddux G. Maddux	520	740	794	52	200	26	16	2.60
7		CC Sabathia	508	560	485	59	177	21	1	2.87
8		Mike Mussina M. Mussina	504	536	486	51	150	6	1	3.36
9		Bartolo Colon B. Colon	481	552	535	58	171	15	2	2.81
10		Frank Tanana F. Tanana	478	612	616	59	209	24	22	2.29
11		Zack Greinke Z. Greinke	473	541	562	51	127	13	0	3.72
12		Clayton Kershaw C. Kershaw	458	429	313	36	130	13	1	3.52
13		Pedro Martinez P. Martinez	443	409	361	41	100	28	0	4.43
14		John Smoltz J. Smoltz	441	481	452	47	192	11	10	2.30
15		Bert Blyleven B. Blyleven	439	544	533	41	174	17	6	2.52
16		A.J. Burnett	432	430	387	28	155	22	2	2.79
17		Curt Schilling C. Schilling	424	436	408	51	109	8	3	3.89
18		Andy Pettitte A. Pettitte	422	521	511	45	172	15	3	2.45
19		Chris Sale C. Sale	416	302	243	28	89	20	1	4.67
20		Jon Lester J. Lester	415	451	442	52	192	16	0	2.16
21		David Cone D. Cone	409	419	364	41	177	19	1	2.31
22		John Lackey J. Lackey	407	446	440	45	147	20	1	2.77
23		Cole Hamels C. Hamels	404	422	380	52	137	17	4	2.95
24		Charlie Morton C. Morton	402	388	350	32	156	45	1	2.58
25		Javier Vazquez J. Vazquez	402	443	435	59	121	13	1	3.32

StatMuse has event-level data for strikeouts going back to the 1974 season.

Some of the information used here was obtained free of charge from Retrosheet.

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