which starting pitcher has the most losses of all-time

Nolan Ryan has lost the most career games by a starting pitcher, with 291 games.

Interpreted as:

Which starting pitcher has the most regular-season losses of all-time?

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	291	318	.478	773	.522	773	3.18	5,654	222	61	0	5326.0	3,880	1,884	2,151	314	2,748	156	0	75	22,310	275	9.55	4.64	2.06	0.53	25.3	12.3	1.24	.265	3.63	6.56
2	Phil Niekro P. Niekro	262	302	.465	716	.535	716	3.37	3,181	245	45	0	5149.2	4,815	1,928	2,227	465	1,703	116	0	73	21,585	207	5.56	2.98	1.87	0.81	14.7	7.9	1.27	.270	3.89	8.42
3	Don Sutton D. Sutton	253	321	.441	756	.559	756	3.27	3,545	178	58	0	5248.1	4,670	1,905	2,095	469	1,333	81	0	96	21,500	110	6.08	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.59	8.01
4	Gaylord Perry G. Perry	252	305	.452	690	.548	690	3.10	3,372	303	53	0	5156.2	4,762	1,778	2,045	382	1,314	101	0	144	21,140	150	5.89	2.29	2.57	0.67	16.0	6.2	1.18	.274	3.57	8.31
5	Walter Johnson W. Johnson	249	376	.398	666	.602	666	1.69	3,273	531	110	0	5552.0	4,610		1,766	90	1,295	191	0			144	5.31	2.10	2.53	0.15		5.8	1.06	.261	2.86	7.47
6	Bert Blyleven B. Blyleven	248	286	.464	685	.536	685	3.31	3,694	242	60	0	4957.1	4,614	1,823	2,021	428	1,316	155	0	67	20,429	114	6.71	2.39	2.81	0.78	18.1	6.4	1.20	.282	3.67	8.38
7	Steve Carlton S. Carlton	240	327	.423	709	.577	709	3.20	4,104	254	55	0	5165.1	4,616	1,835	2,096	405	1,814	53	0	145	21,457	177	7.15	3.16	2.26	0.71	19.1	8.5	1.24	.279	3.65	8.04
8	Robin Roberts R. Roberts	240	275	.466	609	.534	609	3.41	2,292	305	45	0	4567.1	4,467	1,733	1,915	498	872	54	0	63	18,724	32	4.52	1.72	2.63	0.98	12.2	4.7	1.17	.264	3.77	8.80
9	Eppa Rixey E. Rixey	239	247	.492	554	.508	554	3.15	1,244	289	37	0	4171.2	4,335	1,462	1,849	84	982	71	0		17,427	84	2.68	2.12	1.27	0.18	7.1	5.6	1.27	.283	3.99	9.35
10	Frank Tanana F. Tanana	236	236	.500	616	.500	616	3.67	2,734	143	34	0	4136.1	4,019	1,688	1,893	445	1,227	128	0	110	17,413	114	5.95	2.67	2.23	0.97	15.7	7.0	1.27	.278	4.12	8.74
11	Early Wynn E. Wynn	232	287	.447	611	.553	611	3.56	2,255	289	49	0	4398.2	4,135	1,742	1,981	330	1,713	62	0	32	18,704	50	4.61	3.50	1.32	0.68	12.1	9.2	1.33	.265	4.05	8.46
12	Tommy John T. John	228	284	.445	700	.555	700	3.35	2,191	162	46	0	4622.1	4,699	1,718	1,981	295	1,223	98	0	99	19,321	178	4.27	2.38	1.79	0.57	11.3	6.3	1.28	.284	3.86	9.15
13	Warren Spahn W. Spahn	227	358	.388	665	.612	665	3.08	2,501	382	63	0	5101.0	4,703	1,743	1,951	422	1,383	39	0	52	20,960	74	4.41	2.44	1.81	0.74	11.9	6.6	1.19	.258	3.44	8.30
14	Greg Maddux G. Maddux	226	355	.389	740	.611	740	3.15	3,366	109	35	0	5001.0	4,717	1,750	1,974	351	996	137	0	177	20,388	70	6.06	1.79	3.38	0.63	16.5	4.9	1.14	.281	3.55	8.49
15	Fergie Jenkins F. Jenkins	218	278	.440	594	.560	594	3.32	3,082	267	49	0	4358.2	4,021	1,608	1,786	463	951	83	0	101	17,815	61	6.36	1.96	3.24	0.96	17.3	5.3	1.14	.269	3.69	8.30
16	Bob Friend B. Friend	218	186	.540	497	.460	497	3.62	1,642	163	36	0	3378.2	3,560	1,359	1,562	273	822	42	0	102	14,262	48	4.37	2.19	2.00	0.73	11.5	5.8	1.30	.286	4.16	9.48
17	Jim Kaat J. Kaat	217	260	.455	625	.545	625	3.43	2,294	180	31	0	4137.2	4,203	1,579	1,850	366	955	115	0	77	17,336	116	4.99	2.08	2.40	0.80	13.2	5.5	1.25	.282	4.02	9.14
18	Red Ruffing R. Ruffing	212	264	.445	538	.555	538	3.82	1,869	335	45	0	4132.2	4,094	1,755	2,016	249	1,463	51	0		17,623	44	4.07	3.19	1.28	0.54	10.6	8.3	1.34	.275	4.39	8.92
19	Ted Lyons T. Lyons	210	245	.462	484	.538	484	3.60	1,010	356	27	0	3907.0	4,196	1,564	1,900	208	1,027	30	0		16,676	48	2.33	2.37	0.98	0.48	6.1	6.2	1.34	.277	4.38	9.67
20	Bobo Newsom B. Newsom	207	196	.514	483	.486	483	4.00	1,969	246	31	0	3524.2	3,544	1,566	1,797	189	1,598	51	0		15,438	50	5.03	4.08	1.23	0.48	12.8	10.4	1.46	.288	4.59	9.05
21	Jamie Moyer J. Moyer	206	262	.440	638	.560	638	4.27	2,353	33	10	0	3947.1	4,107	1,872	2,020	509	1,104	142	0	64	16,812	52	5.36	2.52	2.13	1.16	14.0	6.6	1.32	.283	4.61	9.36
22	Jerry Koosman J. Koosman	204	216	.486	527	.514	527	3.39	2,464	140	33	0	3681.2	3,495	1,388	1,558	285	1,145	67	0	112	15,342	82	6.02	2.80	2.15	0.70	16.1	7.5	1.26	.282	3.81	8.54
23	Tom Glavine T. Glavine	203	305	.400	682	.600	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	8.76
24	Tom Seaver T. Seaver	203	310	.396	647	.604	647	2.86	3,634	231	61	0	4776.1	3,961	1,517	1,670	378	1,387	76	0	115	19,337	123	6.85	2.61	2.62	0.71	18.8	7.2	1.12	.258	3.15	7.46
25	Sad Sam Jones S. Sam Jones	200	213	.484	488	.516	488	3.80	1,122	250	36	0	3533.1	3,713	1,493	1,789	142	1,264	64	0		15,243	66	2.86	3.22	0.89	0.36	7.4	8.3	1.41	.282	4.56	9.46