InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2001 and 2004 by a large-cap US stock, returning 8,020,800%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2001-2004	8,020,800%
Axon Enterprise (AXON)	2001-2004	5,326.02%
Cheniere Energy (LNG)	2001-2004	2,576.47%
Tractor Supply (TSCO)	2001-2004	1,650.74%
NetEase (NTES)	2001-2004	1,593.33%
ArcelorMittal SA ADR (MT)	2001-2004	1,527.37%
Monster Beverage (MNST)	2001-2004	855.42%
Chunghwa Telecom (CHT)	2001-2004	845.27%
Deckers Outdoor (DECK)	2001-2004	839.74%
Clean Harbors (CLH)	2001-2004	747.18%
Grupo Cibest (CIB)	2001-2004	695.83%
Tapestry (TPR)	2001-2004	688.11%
Old Dominion Freight Line (ODFL)	2001-2004	682.92%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2004	596.4%
eBay (EBAY)	2001-2004	590.71%
Royal Gold (RGLD)	2001-2004	540.92%
Cameco (CCJ)	2001-2004	529.39%
NVR (NVR)	2001-2004	522.49%
Genesis Healthcare (GEN)	2001-2004	503.91%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2001-2004	498.78%
CME (CME)	2001-2004	497.24%
Centene (CNC)	2001-2004	495.99%
Pan American Silver (PAAS)	2001-2004	487.76%
Autodesk (ADSK)	2001-2004	481.41%
Dick’s Sporting Goods (DKS)	2001-2004	474.34%

Large-cap stocks are treated as having a market cap of $10B+.