Axsome Therapeutics (AXSM) had the highest return between 2019 and 2022 by a large-cap US stock, returning 2,644.8%.

ASSET	YEARS	% RETURN
Axsome Therapeutics (AXSM)	2019-2022	2,644.84%
Moderna (MRNA)	2019-2022	1,103.08%
Lattice Semiconductor (LSCC)	2019-2022	845.77%
BioNTech SE (BNTX)	2019-2022	822.48%
Sitime (SITM)	2019-2022	681.69%
Cytokinetics (CYTK)	2019-2022	636.66%
Tesla (TSLA)	2019-2022	503.63%
Super Micro Computer (SMCI)	2019-2022	495.36%
Leonardo DRS, Inc Common Stock (DRS)	2019-2022	405.14%
Quanta Services (PWR)	2019-2022	387.42%
Texas Pacific Land (TPL)	2019-2022	374.86%
Rambus (RMBS)	2019-2022	374.44%
Sea (SE)	2019-2022	367.9%
KLA (KLAC)	2019-2022	360.5%
Ares Management (ARES)	2019-2022	355.87%
NVIDIA (NVDA)	2019-2022	350.76%
Dick’s Sporting Goods (DKS)	2019-2022	349.92%
United Microelectronics (UMC)	2019-2022	348.52%
MACOM Technology Solutions (MTSI)	2019-2022	344.46%
TFI International (TFII)	2019-2022	314.56%
Medpace (MEDP)	2019-2022	307.38%
Freeport-McMoran Copper & Gold (FCX)	2019-2022	297.35%
argenx NV ADR (ARGX)	2019-2022	288.15%
Krystal Biotech (KRYS)	2019-2022	287.95%
Synopsys (SNPS)	2019-2022	287.63%

Large-cap stocks are treated as having a market cap of $10B+.