MicroStrategy (MSTR) had the highest return in Q4 2001 by a large-cap US stock, returning 234.8%.

ASSET	QUARTER	% RETURN
MicroStrategy (MSTR)	Q4 2001	234.78%
NetApp (NTAP)	Q4 2001	231.91%
Western Digital (WDC)	Q4 2001	190.26%
Marvell Technology (MRVL)	Q4 2001	148.75%
NVIDIA (NVDA)	Q4 2001	143.66%
F5 Networks (FFIV)	Q4 2001	139.07%
Take-Two Interactive Software (TTWO)	Q4 2001	128.07%
Accenture (ACN)	Q4 2001	112.81%
Akamai Technologies (AKAM)	Q4 2001	102.04%
Juniper Networks (JNPR)	Q4 2001	96.39%
Genesis Healthcare (GEN)	Q4 2001	94%
Advanced Micro Devices (AMD)	Q4 2001	91.08%
ASE Industrial Holding Co Ltd ADR (ASX)	Q4 2001	90.85%
Check Point Software Technologies (CHKP)	Q4 2001	88.16%
Taiwan Semiconductor Manufacturing (TSM)	Q4 2001	86.62%
Align Technology (ALGN)	Q4 2001	85.19%
Tractor Supply (TSCO)	Q4 2001	84.11%
Hologic (HOLX)	Q4 2001	83.96%
Amazon (AMZN)	Q4 2001	83.08%
United Microelectronics (UMC)	Q4 2001	82.85%
Williams-Sonoma (WSM)	Q4 2001	82.55%
Cognizant Technology Solutions Corp Class A (CTSH)	Q4 2001	82.13%
Infosys Ltd ADR (INFY)	Q4 2001	81.21%
Illumina (ILMN)	Q4 2001	80.92%
JB Hunt Transport Services (JBHT)	Q4 2001	78.46%

Large-cap stocks are treated as having a market cap of $10B+.