QXO (QXO) had the highest return between 2011 and 2014 by a large-cap US stock, returning 7,392,225%.

ASSET	YEARS	% RETURN
QXO (QXO)	2011-2014	7,392,225%
Regeneron Pharmaceuticals (REGN)	2011-2014	1,154.97%
Cheniere Energy (LNG)	2011-2014	1,152.66%
Alnylam Pharmaceuticals (ALNY)	2011-2014	878.81%
Expedia (EXPE)	2011-2014	766.08%
Tesla (TSLA)	2011-2014	728.66%
Jazz Pharmaceuticals (JAZZ)	2011-2014	723.59%
Domino's Pizza Inc Common Stock (DPZ)	2011-2014	548.6%
Ionis Pharmaceuticals (IONS)	2011-2014	505.29%
Axon Enterprise (AXON)	2011-2014	457.47%
Tyler Technologies (TYL)	2011-2014	422.64%
Gilead Sciences (GILD)	2011-2014	414.52%
Seagate Technology (STX)	2011-2014	407.29%
Biogen (BIIB)	2011-2014	401.55%
Saia (SAIA)	2011-2014	400.54%
Corpay (CPAY)	2011-2014	375.87%
Pilgrims Pride (PPC)	2011-2014	359.89%
EXACT Sciences (EXAS)	2011-2014	352.81%
Constellation Brands Inc Class A (STZ)	2011-2014	342.61%
Targa Resources (TRGP)	2011-2014	341.9%
Incyte (INCY)	2011-2014	341.49%
United Rentals (URI)	2011-2014	340.84%
Generac (GNRC)	2011-2014	334.29%
Genmab A-S (GMAB)	2011-2014	334.07%
Micron Technology (MU)	2011-2014	330.1%

Large-cap stocks are treated as having a market cap of $10B+.