QXO (QXO) had the highest return in April 2011 by a large-cap US stock, returning 125%.

ASSET	MONTH	% RETURN
QXO (QXO)	April 2011	125%
Applied Digital (APLD)	April 2011	60%
Biogen (BIIB)	April 2011	32.69%
Insmed (INSM)	April 2011	28.34%
Huazhu (HTHT)	April 2011	25.01%
Pool (POOL)	April 2011	24.42%
Somnigroup International (SGI)	April 2011	23.22%
Seagate Technology (STX)	April 2011	22.58%
Stellantis (STLA)	April 2011	22.29%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	April 2011	21.68%
Carpenter Technology (CRS)	April 2011	20.08%
Monolithic Power Systems (MPWR)	April 2011	18.82%
Dillard's (DDS)	April 2011	18.8%
Align Technology (ALGN)	April 2011	17.3%
Albemarle (ALB)	April 2011	17.08%
Trip Group Ltd ADR (TCOM)	April 2011	16.81%
Fresenius Medical Care (FMS)	April 2011	16.23%
Incyte (INCY)	April 2011	16.23%
Coherent (COHR)	April 2011	15.56%
Charter Communications (CHTR)	April 2011	15.55%
Westlake Chemical (WLK)	April 2011	15.44%
Madrigal Pharmaceuticals (MDGL)	April 2011	15.18%
Royal Gold (RGLD)	April 2011	15.06%
Corpay (CPAY)	April 2011	14.71%
Vertex Pharmaceuticals (VRTX)	April 2011	14.69%

Large-cap stocks are treated as having a market cap of $10B+.