Insmed (INSM) had the highest return in November 2008 by a large-cap US stock, returning 58.6%.

ASSET	MONTH	% RETURN
Insmed (INSM)	November 2008	58.57%
Aecom Technology (ACM)	November 2008	48.32%
Royal Gold (RGLD)	November 2008	39.66%
Fidelity National Financial (FNF)	November 2008	38.38%
Kinross Gold (KGC)	November 2008	37.34%
Agnico Eagle Mines (AEM)	November 2008	31.22%
Archer-Daniels-Midland (ADM)	November 2008	31.05%
Gold Fields Ltd ADR (GFI)	November 2008	28.44%
Newmont Goldcorp (NEM)	November 2008	28.24%
Booking (BKNG)	November 2008	27.45%
Essential Utilities (WTRG)	November 2008	21.46%
Jacobs Solutions (J)	November 2008	21.03%
Grupo Aeroportuario del Pacifico SAB De CV ADR (PAC)	November 2008	20.32%
Ford Motor (F)	November 2008	19.55%
Aegon NV ADR (AEG)	November 2008	19.54%
Molson Coors Beverage (TAP.A)	November 2008	19.46%
AngloGold Ashanti (AU)	November 2008	18.61%
Transdigm (TDG)	November 2008	18.14%
Monster Beverage (MNST)	November 2008	16.94%
Automatic Data Processing (ADP)	November 2008	16.48%
Hologic (HOLX)	November 2008	15.63%
Telefonica SA ADR (TEF)	November 2008	15.15%
Molson Coors Brewing (TAP)	November 2008	14.63%
Rockwell Automation (ROK)	November 2008	14.52%
Warner Bros Discovery (WBD)	November 2008	13.64%

Large-cap stocks are treated as having a market cap of $10B+.