Cisco Systems (CSCO) had the highest return between 1993 and 1997 by a mega-cap US stock, returning 749.5%.

ASSET	YEARS	% RETURN
Cisco Systems (CSCO)	1993-1997	749.48%
Citigroup (C)	1993-1997	614.28%
Applied Materials (AMAT)	1993-1997	608.83%
Micron Technology (MU)	1993-1997	591.45%
Intel (INTC)	1993-1997	554.42%
Microsoft (MSFT)	1993-1997	508.25%
ASML Holding NV ADR (ASML)	1993-1997	500%
Eli Lilly and (LLY)	1993-1997	437.03%
Oracle (ORCL)	1993-1997	433.15%
American Express (AXP)	1993-1997	360.68%
International Business Machines (IBM)	1993-1997	337.69%
Morgan Stanley (MS)	1993-1997	323.29%
Wells Fargo (WFC)	1993-1997	311.93%
AstraZeneca PLC ADR (AZN)	1993-1997	306.46%
Berkshire Hathaway (BRK.A)	1993-1997	292.32%
GE Aerospace (GE)	1993-1997	287.83%
Caterpillar (CAT)	1993-1997	260.12%
JPMorgan Chase (JPM)	1993-1997	246.72%
Raytheon Technologies (RTX)	1993-1997	244.16%
Coca-Cola (KO)	1993-1997	240.56%
Novo Nordisk A-S (NVO)	1993-1997	238.82%
Procter & Gamble (PG)	1993-1997	228.03%
Thermo Fisher Scientific (TMO)	1993-1997	215.13%
Shell PLC ADR (SHEL)	1993-1997	196.55%
Johnson & Johnson (JNJ)	1993-1997	188.73%

Mega-cap stocks are treated as having a market cap of $200B+.