ASML Holding NV ADR (ASML) had the highest return between 1995 and 1997 by a mega-cap US stock, returning 500%.

ASSET	YEARS	% RETURN
ASML Holding NV ADR (ASML)	1995-1997	500%
Citigroup (C)	1995-1997	423.48%
Cisco Systems (CSCO)	1995-1997	377.87%
Eli Lilly and (LLY)	1995-1997	355.21%
Microsoft (MSFT)	1995-1997	320.32%
Morgan Stanley (MS)	1995-1997	280.78%
Wells Fargo (WFC)	1995-1997	266.38%
Costco Wholesale (COST)	1995-1997	246.6%
JPMorgan Chase (JPM)	1995-1997	246.53%
American Express (AXP)	1995-1997	220.62%
Novo Nordisk A-S (NVO)	1995-1997	216.64%
GE Aerospace (GE)	1995-1997	208.95%
Bank of America (BAC)	1995-1997	204.75%
Merck (MRK)	1995-1997	197.87%
International Business Machines (IBM)	1995-1997	193.6%
Applied Materials (AMAT)	1995-1997	188.63%
AstraZeneca PLC ADR (AZN)	1995-1997	184.37%
Procter & Gamble (PG)	1995-1997	172.67%
Coca-Cola (KO)	1995-1997	167.8%
Johnson & Johnson (JNJ)	1995-1997	152.95%
Royal Bank of Canada (RY)	1995-1997	147.91%
Raytheon Technologies (RTX)	1995-1997	147.9%
LIN TV (LIN)	1995-1997	127.73%
Berkshire Hathaway (BRK.A)	1995-1997	124.39%
Shell PLC ADR (SHEL)	1995-1997	124.3%

Mega-cap stocks are treated as having a market cap of $200B+.