Cipher Mining (CIFR) had the highest return in Q1 2023 by a mid-cap US stock, returning 303.1%.

ASSET	QUARTER	% RETURN
Cipher Mining (CIFR)	Q1 2023	303.11%
BigBearai (BBAI)	Q1 2023	240.78%
Riot Blockchain (RIOT)	Q1 2023	186.25%
Oscar Health (OSCR)	Q1 2023	161.6%
Kingsoft Cloud Holdings (KC)	Q1 2023	123.37%
Hut 8 Corp Common Stock (HUT)	Q1 2023	116.88%
Sotera Health (SHC)	Q1 2023	112.2%
Protagonist Therapeutics (PTGX)	Q1 2023	108.71%
Immunome (IMNM)	Q1 2023	107.92%
Duolingo (DUOL)	Q1 2023	100.46%
Aurinia Pharmaceuticals (AUPH)	Q1 2023	94.33%
Ocular Therapeutix (OCUL)	Q1 2023	83.62%
Eos Energy Enterprises (EOSE)	Q1 2023	83.57%
Viking Therapeutics (VKTX)	Q1 2023	81.18%
Intapp (INTA)	Q1 2023	79.36%
Cinemark (CNK)	Q1 2023	68.64%
Axcelis Technologies (ACLS)	Q1 2023	65.16%
Rumble (RUM)	Q1 2023	64.74%
Cidara Therapeutics (CDTX)	Q1 2023	63.87%
Miniso Group Holding (MNSO)	Q1 2023	61.27%
Lantheus (LNTH)	Q1 2023	60.47%
Structure Therapeutics Inc American Depositary Shares (GPCR)	Q1 2023	58.6%
Allegro Microsystems (ALGM)	Q1 2023	58.59%
SoundHound AI (SOUN)	Q1 2023	57.71%
Perpetua Resources (PPTA)	Q1 2023	52.92%

Mid-cap stocks are treated as having a market cap between $2B and $10B.