Axsome Therapeutics (AXSM) had the highest return between 2018 and 2019 by a US stock or US stock with a market cap of $2B+, returning 1,729.4%.

ASSET	YEARS	% RETURN
Axsome Therapeutics (AXSM)	2018-2019	1,729.38%
Arrowhead Pharmaceuticals (ARWR)	2018-2019	1,618.97%
Enphase Energy (ENPH)	2018-2019	993.31%
Aura Minerals Inc Common Shares (AUGO)	2018-2019	822.31%
Weatherford International (WFRD)	2018-2019	655.4%
Zymeworks Inc Common Stock (ZYME)	2018-2019	491.16%
Trade Desk (TTD)	2018-2019	468.57%
Krystal Biotech (KRYS)	2018-2019	453.8%
Carvana (CVNA)	2018-2019	380.43%
Xenon Pharmaceuticals (XENE)	2018-2019	368.21%
Okta (OKTA)	2018-2019	351.55%
Aurinia Pharmaceuticals (AUPH)	2018-2019	345.27%
Advanced Micro Devices (AMD)	2018-2019	340.12%
MongoDB (MDB)	2018-2019	339.73%
Magnite (MGNI)	2018-2019	336.36%
Veracyte (VCYT)	2018-2019	326.26%
Twilio (TWLO)	2018-2019	307.29%
DexCom (DXCM)	2018-2019	279.63%
Quantum Computing (QUBT)	2018-2019	275%
Natera (NTRA)	2018-2019	271.04%
Goosehead Insurance (GSHD)	2018-2019	259.27%
Acm Research (ACMR)	2018-2019	251.43%
Ascendis Pharma A-S (ASND)	2018-2019	246.07%
Ringcentral (RNG)	2018-2019	245.64%
Crocs (CROX)	2018-2019	231.41%