Madrigal Pharmaceuticals (MDGL) had the highest return in Q4 2022 by a US stock with a market cap of $2B+, returning 336.6%.

ASSET	QUARTER	% RETURN
Madrigal Pharmaceuticals (MDGL)	Q4 2022	336.6%
Summit Therapeutics (SMMT)	Q4 2022	254.17%
Viking Therapeutics (VKTX)	Q4 2022	240.58%
Immunovant (IMVT)	Q4 2022	213.05%
Roivant Sciences (ROIV)	Q4 2022	151.26%
IAMGold (IAG)	Q4 2022	130.36%
RLX Technology (RLX)	Q4 2022	116.97%
Oceaneering International (OII)	Q4 2022	107.72%
Tencent Music Entertainment (TME)	Q4 2022	105.97%
F&G Annuities & Life (FG)	Q4 2022	100.1%
Miniso Group Holding (MNSO)	Q4 2022	99.44%
Wave Life Sciences (WVE)	Q4 2022	96.63%
TG Therapeutics (TGTX)	Q4 2022	96.51%
Vaxcyte (PCVX)	Q4 2022	95.71%
Kingsoft Cloud Holdings (KC)	Q4 2022	88.67%
Burlington Stores (BURL)	Q4 2022	79.21%
Transocean (RIG)	Q4 2022	75.38%
Manchester United (MANU)	Q4 2022	75.28%
Melco Resorts & Entertainment (MLCO)	Q4 2022	72.93%
Axsome Therapeutics (AXSM)	Q4 2022	69.33%
Turkcell Iletisim Hizmetleri AS (TKC)	Q4 2022	68.66%
Powell Industries (POWL)	Q4 2022	65.54%
Terns Pharmaceuticals (TERN)	Q4 2022	65.53%
HUTCHMED DRC (HCM)	Q4 2022	65.14%
BeiGene (ONC)	Q4 2022	65.1%