Enlight Renewable Energy Ltd Ordinary Shares (ENLT) had the highest return between 2022 and 2023 by a large-cap US stock, returning 714.5%.

ASSET	YEARS	% RETURN
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2022-2023	714.47%
Super Micro Computer (SMCI)	2022-2023	537.21%
Modine Manufacturing (MOD)	2022-2023	483.58%
Symbotic (SYM)	2022-2023	412.28%
YPF Sociedad Anonima (YPF)	2022-2023	346.49%
QXO (QXO)	2022-2023	300.23%
Applied Opt (AAOI)	2022-2023	271.54%
TechnipFMC (FTI)	2022-2023	231.88%
Sterling Infrastructure (STRL)	2022-2023	231.19%
Constellation Energy (CEG)	2022-2023	214.17%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2022-2023	193.98%
Allegheny Technologies (ATI)	2022-2023	183.83%
Madrigal Pharmaceuticals (MDGL)	2022-2023	169.52%
Fair Isaac (FICO)	2022-2023	166.27%
Celestica (CLS)	2022-2023	162.84%
PDD (PDD)	2022-2023	150.75%
Carpenter Technology (CRS)	2022-2023	149.29%
Marathon Petroleum (MPC)	2022-2023	141.77%
BridgeBio Pharma (BBIO)	2022-2023	135.45%
Permian Resources (PR)	2022-2023	132.07%
Rambus (RMBS)	2022-2023	132.06%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2022-2023	123.26%
Eli Lilly and (LLY)	2022-2023	117.43%
Leonardo DRS, Inc Common Stock (DRS)	2022-2023	110.73%
Axsome Therapeutics (AXSM)	2022-2023	109.83%

Large-cap stocks are treated as having a market cap of $10B+.