Riot Platforms (RIOT) had the highest return between 2006 and 2008 by a large-cap US stock, returning 517%.

ASSET	YEARS	% RETURN
Riot Platforms (RIOT)	2006-2008	517%
First Solar (FSLR)	2006-2008	463.1%
Illumina (ILMN)	2006-2008	265.62%
Mastercard (MA)	2006-2008	257.63%
Booking (BKNG)	2006-2008	229.95%
CF Industries (CF)	2006-2008	225.64%
Sumitomo Mitsui Financial (SMFG)	2006-2008	221.48%
Deckers Outdoor (DECK)	2006-2008	180.34%
Ionis Pharmaceuticals (IONS)	2006-2008	168.05%
Agnico Eagle Mines (AEM)	2006-2008	157.13%
Credicorp (BAP)	2006-2008	140.52%
Intercontinental Exchange (ICE)	2006-2008	125.86%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2006-2008	123.87%
Clean Harbors (CLH)	2006-2008	120.74%
Baidu (BIDU)	2006-2008	103.22%
Kinross Gold (KGC)	2006-2008	96.59%
McDonald’s (MCD)	2006-2008	96.13%
Elbit Systems (ESLT)	2006-2008	96.12%
Gilead Sciences (GILD)	2006-2008	92.98%
Ambev SA ADR (ABEV)	2006-2008	90.03%
Novo Nordisk A-S (NVO)	2006-2008	88.81%
Valmont Industries (VMI)	2006-2008	86.2%
Southern Copper (SCCO)	2006-2008	85.4%
Alnylam Pharmaceuticals (ALNY)	2006-2008	84.69%
AAON (AAON)	2006-2008	82.32%

Large-cap stocks are treated as having a market cap of $10B+.