National Grid PLC ADR (NGG) had the highest return between 2005 and 2010 by a large-cap US stock, returning 538,293.9%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2005-2010	538,293.94%
Ferguson (FERG)	2005-2010	69,150%
Booking (BKNG)	2005-2010	1,584.45%
Baidu (BIDU)	2005-2010	1,362.58%
Netflix (NFLX)	2005-2010	1,307.82%
Illumina (ILMN)	2005-2010	1,244.8%
Wheaton Precious Metals (WPM)	2005-2010	1,159.37%
Monster Beverage (MNST)	2005-2010	1,018.54%
Apple (AAPL)	2005-2010	895.82%
Southern Copper (SCCO)	2005-2010	855.02%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2005-2010	848.18%
Credicorp (BAP)	2005-2010	800.02%
CF Industries (CF)	2005-2010	749.97%
Salesforce (CRM)	2005-2010	704.38%
Banco Bradesco SA ADR (BBD)	2005-2010	667.74%
Trip Group Ltd ADR (TCOM)	2005-2010	616.3%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2010	601.3%
Intuitive Surgical (ISRG)	2005-2010	544.06%
Ambev SA ADR (ABEV)	2005-2010	543.93%
Alamos Gold (AGI)	2005-2010	539.01%
TechnipFMC (FTI)	2005-2010	492.77%
Agnico Eagle Mines (AEM)	2005-2010	471.35%
Tenaris SA ADR (TS)	2005-2010	469.87%
Cummins (CMI)	2005-2010	468.96%
Mastercard (MA)	2005-2010	464.18%

Large-cap stocks are treated as having a market cap of $10B+.